FPGA-based reconfigurable processor for ultrafast interlaced ultrasound and photoacoustic imaging

IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control

Volumn 59, Issue 7, 2012, Pages 1344-1353

  Alqasemi, Umar ^a   Li, Hai ^b   Aguirre, Andrés ^b   Zhu, Quing ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b University of Connecticut   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACQUISITION PROCESS; ANALOG AND DIGITAL CIRCUITS; DELAY AND SUMS; EXTERNAL MEMORY; FPGA CONTROL; IMAGING MODES; IN-VIVO; INTERNAL MEMORY; LASER SYNCHRONIZATIONS; MEMORY SIZE; MOUSE TUMORS; MULTI-THREAD; PHOTO-ACOUSTIC IMAGING; PROCESSING LOAD; PULSE ECHOES; REAL-TIME SWITCHING; RECONFIGURABLE PROCESSORS; TRANSMISSION CONTROL; ULTRA-FAST;

DYNAMIC RESPONSE; FIELD PROGRAMMABLE GATE ARRAYS (FPGA); PHOTOACOUSTIC EFFECT; SIGNAL PROCESSING; TUMORS; ULTRASONICS;

RECONFIGURABLE HARDWARE;

ALGORITHM; ARTICLE; AUTOMATED PATTERN RECOGNITION; COMPUTER ASSISTED DIAGNOSIS; ECHOGRAPHY; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; IMAGE ENHANCEMENT; IMAGE SUBTRACTION; INFORMATION RETRIEVAL; INSTRUMENTATION; METHODOLOGY; PHOTOACOUSTICS; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SIGNAL PROCESSING;

ALGORITHMS; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; IMAGE ENHANCEMENT; IMAGE INTERPRETATION, COMPUTER-ASSISTED; INFORMATION STORAGE AND RETRIEVAL; PATTERN RECOGNITION, AUTOMATED; PHOTOACOUSTIC TECHNIQUES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SIGNAL PROCESSING, COMPUTER-ASSISTED; SUBTRACTION TECHNIQUE; ULTRASONOGRAPHY;

EID: 84864199998     PISSN: 08853010     EISSN: None     Source Type: Journal    
DOI: 10.1109/TUFFC.2012.2335     Document Type: Article

References (46)

1. L. V. Wang, "Ultrasound-mediated biophotonic imaging: A review of acousto-optical tomography and photoacoustic tomography," Dis. Markers, vol. 19, no. 2-3, pp. 123-138, 2003. (Pubitemid 38530357)
2. J. L. Prince and J. M. Links, Medical Imaging Signals and Systems. Upper Saddle River, NJ: Pearson Prentice Hall, 2006, ch. 10 and 11.
3. S. Y. Emelianov, S. R. Aglyamov, J. Shah, S. Sethuraman, W. G. Scott, R. Schmitt, M. Motamedi, A. Karpiouk, and A. Oraevsky, "Combined ultrasound, optoacoustic and elasticity imaging," Proc. SPIE, vol. 5320, pp. 101-112, 2004. (Pubitemid 40108951)
4. S. Y. Emelianov, S. R. Aglyamov, A. B. Karpiouk, S. Mallidi, S. Park, S. Sethuraman, J. Shah, R. W. Smalling, J. M. Rubin, and W. G. Scott, "Synergy and applications of combined ultrasound, elasticity, and photoacoustic imaging," in IEEE Ultrasonics Symp., 2006, pp. 405-415.
5. S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, "Laser optoacoustic imaging system for detection of breast cancer," J. Biomed. Opt., vol. 14, no. 2, art. no. 024007, Mar./Apr. 2009.
6. A. Aguirre, P. Guo, J. Gamelin, S. Yan, M. Sanders, M. Brewer, and Q. Zhu, "Co-registered 3-D ultrasound and photoacoustic imaging system for ovarian tissue characterization," J. Biomed. Opt., vol. 14, no. 5, art. no. 054014, 2009.
7. A. Aguirre, Y. Ardeshirpour, M. Sanders, M. Brewer, and Q. Zhu, "Potential role of co-registered photoacoustic and ultrasound imaging in ovarian cancer/detection and characterization," Transl. Oncol., vol. 4, no. 1, pp. 29-37, 2011.
8. X. L. Deán-Ben, V. Ntziachristos, and D. Razansky, "Statistical optoacoustic image reconstruction using a-priori knowledge on the location of acoustic distortions," Appl. Phys. Lett., vol. 98, no. 17, art. no. 171110, Apr. 2011.
9. D. Modgil and P. J. La Riviére, "Image reconstruction in photoacoustic tomography with variable speed of sound using a higherorder geometrical acoustics approximation," J. Biomed. Opt., vol. 15, no. 2, art. no. 021308, Mar. 2010.
10. B. T. Cox, S. Kara, S. R. Arridge, and P. C. Beard, "k-Space propagation models for acoustically heterogeneous media: Application to biomedical photoacoustics," J. Acoust. Soc. Am., vol. 121, no. 6, pp. 3453-3464, 2007. (Pubitemid 46872104)
11. J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, "Combined ultrasound and optoacoustic system for real-time highcontrast vascular imaging in vivo," IEEE Trans. Med. Imaging, vol. 24, no. 4, pp. 436-440, Apr. 2005. (Pubitemid 40538200)
12. S. Sethuraman, S. R. Aglyamov, J. H. Amirian, R. W. Smalling, and S. Y. Emelianov, "Development of a combined intravascular ultrasound and photoacoustic imaging system," in Proc. SPIE Photonics West, 2006, vol. 6086, pp. F1-F10.
13. P. Guo, J. Gamelin, S. Yan, A. Aguirre, and Q. Zhu, "Co-registered 3-D ultrasound and photoacoustic imaging using a 1.75D 1280-channel ultrasound system," Proc. SPIE, vol. 6437, art. no. 643713, 2007.
14. R. G. M. Kolkman, P. J. Brands, W. Steenbergen, and T. G. van Leeuwen, "Real-time in vivo photoacoustic and ultrasound imaging," J. Biomed. Opt., vol. 13, no. 5, art. no. 050510, Sep./Oct. 2008.
15. S. A. Ermilov, M. P. Fronheiser, H.-P. Brecht, R. Su, A. Conjusteau, K. Mehta, P. Otto, and A. A. Oraevsky, "Development of laser optoacoustic and ultrasonic imaging system for breast cancer utilizing handheld array probes," Proc. SPIE, vol. 7177, art. no. 717703, 2009.
16. T. Harrison, J. C. Ranasinghesagara, H. Lu, K. Mathewson, A. Walsh, and R. J. Zemp, "Combined photoacoustic and ultrasound biomicroscopy," Opt. Express, vol. 17, no. 24, pp. 22041-22046, Nov. 2009.
17. C .-H. Hu, X.-C. Xu, J. M. Cannata, J. T. Yen, and K. K. Shung, "Development of a real-time, high-frequency ultrasound digital beamformer for high-frequency linear array transducers," IEEE Trans. Ultrason. Ferroelectr. Freq. Control, vol. 53, no. 2, pp. 317-323, 2006.
18. I. K. H. Tsang, B. Y. S. Yiu, D. K. H. Cheung, H. C. T. Chiu, C. C. P. Cheung, and A. C. H. Yu, "Design of a multi-channel pre-beamform data acquisition system for an ultrasound research scanner," in Proc. IEEE Int. Ultrasonics Symp., 2009, pp. 1840-1843.
19. S. Hauck, and A. DeHon, Reconfigurable Computing: The Theory and Practice of FPGA-Based Computation. Amsterdam, The Netherlands: Elsevier, 2008.
20. Octal LNA/VGA/AAF/ADC and Crosspoint Switch: AD9272, Rev. C, Analog Devices, Inc., Norwood, MA, 2007.
21. Evaluating the AD9272/AD9273 for Ultrasound Systems: Evaluation Board User Guide, UG001, Rev. 0, Analog Devices, Inc., Norwood, MA, 2009.
22. High Speed Converter Evaluation Platform: HSC-ADC-EVALC, Rev. 0, Analog Devices, Inc., Norwood, MA, 2007.
23. J. Gamelin, A. Maurudis, A. Aguirre, F. Huang, P. Guo, L. V. Wang, and Q. Zhu, "A real-time photoacoustic tomography system for small animals," Opt. Express, vol. 17, no. 13, pp. 10489-10498, 2009.
24. J. Gamelin, A. Aguirre, A. Maurudis, F. Huang, D. Castillo, L. V. Wang, and Q. Zhu, "Curved array photoacoustic tomographic system for small animal imaging," J. Biomed. Opt., vol. 13, no. 2, art. no. 024007, May/Jun. 2008.
25. P. Guo, "Three dimensional ultrasound imaging and its application in combined near-infrared optical imaging and co-registered photoacoustic imaging," Ph.D. dissertation, Dept. Electrical and Computer Engineering, University of Connecticut, Storrs, CT, 2007, pp. 1-3.
26. C. Roth, Jr. and L. L. Kinney, Fundamentals of Logic Design, 6th ed., Independence, KY: CENGAGE Learning, 2010.
27. K.-C. Chang, Digital Systems Design With VHDL and Synthesis: An Integrated Approach. New York, NY: Wiley-IEEE Computer Society Press, 1999.
28. E. D'Hollander, G. R. Joubert, F. Peters, and U. Trottenberg, Parallel Computing: Fundamentals, Applications, and New Directions. Amsterdam, The Netherlands: Elsevier Science, 1998.
29. TMS320C6455 DSK Technical Reference, Rev. C, Spectrum Digital Inc., Stafford, TX, 2006.
30. W. Maichen, Digital Timing Measurements: From Scopes and Probes to Timing and Jitter. New York, NY: Springer, 2006.
31. Virtex-4 FPGA User Guide, UG070 (v2.6), Xilinx Inc., San Jose, CA, Dec. 1, 2008.
32. W. Gautschi, Numerical Analysis: An Introduction, Cambridge, MA: Birkhauser Boston, 1997, ch. 2.
33. N. G. Chen, P. Y. Guo, S. K. Yan, D. Q. Piao, and Q. Zhu, "Simultaneous near infrared diffusive light and ultrasound imaging," Appl. Opt., vol. 40, no. 34, pp. 6367-6380, Dec. 2001.
34. N. C. Biswal, C. Pavlik, M. B. Smith, A. Aguirre, Y. Xu, S. Zanganeh, L. T. Kuhn, K. P. Claffey, and Q. Zhu, "Imaging tumor hypoxia by near infrared fluorescence tomography," J. Biomed. Opt., vol. 16, art. no. 066009, Jun. 2011.
35. J. Laufer, C. Elwell, D. Delpy, and P. Beard, "In vitro measurements of absolute blood oxygen saturation using pulsed near-infrared photoacoustic spectroscopy: Accuracy and resolution," Phys. Med. Biol., vol. 50, no. 18, pp. 4409-4428, 2005. (Pubitemid 41285966)
36. X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, "Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain," Nat. Biotechnol., vol. 21, no. 7, pp. 803-806, Jul. 2003. (Pubitemid 36791400)
37. L. V. Wang, X. Wang, G. Ku, X. Xie, and G. Stoica, "High-resolution spectroscopic photoacoustic tomography for non-invasive functional imaging of small-Animal brains in vivo," in Second Asian and Pacific Rim Symp. Biophotonics, 2004, pp. 246-247. (Pubitemid 40858869)
38. X. Wang, X. Xie, G. Ku, L. V. Wang, and G. Stoica, "Noninvasive imaging of hemoglobin concentration and oxygenation in the rat brain using high-resolution photoacoustic tomography," J. Biomed. Opt., vol. 11, art. no. 024015, May 2006.
39. L .V. Wang and H. Wu, Biomedical Optics: Principles and Imaging. New York, NY: Wiley, 2007, ch. 12.
40. V. Tuchin and T. Optics, Light Scattering Methods and Instruments for Medical Diagnosis, 2nd ed., Bellingham, WA: SPIE Press, 2000.
41. B. L. Horecker, "The absorption spectra of hemoglobin and its derivatives in the visible and near infrared regions," J. Biol. Chem., vol. 148, no. 1, pp. 173-183, 1943.
42. E. J. van Kampen and W. G. Zijlstra, "Determination of hemoglobin and its derivatives," Adv. Clin. Chem., vol. 8, pp. 141-187, 1965.
43. W. G. Zijlstra, A. Buursma, and A. Zwart, "Molar absorptivities of human hemoglobin in the visible spectral range," J. Appl. Physiol., vol. 54, no. 5, pp. 1287-1291, 1983. (Pubitemid 13098977)
44. L. Cordone, A. Cupane, M. Leone, and E. Vitrano, "Optical absorption spectra of deoxy-And oxyhemoglobin in the temperature range 300-20 K," Biophys. Chem., vol. 24, no. 3, pp. 259-275, 1986. (Pubitemid 16004626)
45. J. G. Kim, M. Xia, and H. Liu, "Extinction coefficients of hemoglobin for near-infrared spectroscopy of tissue," IEEE Eng. Med. Biol. Mag., vol. 24, no. 2, pp. 118-121, 2005. (Pubitemid 40559026)
46. Y. Bar-Shalom, X. R. Li, and T. Kirubarajan, Estimation with Applications to Tracking and Navigation. New York, NY: Wiley, 2001.