Structure of human POFUT2: Insights into thrombospondin type 1 repeat fold and O-fucosylation

EMBO Journal

Volumn 31, Issue 14, 2012, Pages 3183-3197

  Chen, Chun I ^a   Keusch, Jeremy J ^a   Klein, Dominique ^a   Hess, Daniel ^a   Hofsteenge, Jan ^a   Gut, Heinz ^a  

^a FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

Author keywords

crystal structure; enzymatic mechanism; GDPfucose; protein O fucosyltransferase 2; thrombospondin type 1 repeat

Indexed keywords

CALCIUM CHLORIDE; EDETIC ACID; FUCOSE; MAGNESIUM CHLORIDE; MANGANESE CHLORIDE; PROTEIN O FUCOSYLTRANSFERASE 2; THROMBOSPONDIN 1; TRANSFERASE; UNCLASSIFIED DRUG; ZINC CHLORIDE;

ARTICLE; BINDING SITE; CATALYSIS; CONSENSUS SEQUENCE; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME SUBSTRATE; FUCOSYLATION; HUMAN; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN GLYCOSYLATION; PROTEIN PROCESSING; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

CRYSTALLOGRAPHY, X-RAY; FUCOSE; FUCOSYLTRANSFERASES; GLYCOSYLATION; HUMANS; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; REPETITIVE SEQUENCES, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84864149706     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2012.143     Document Type: Article

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