Duration of luteal support (DOLS) with progesterone pessaries to improve the success rates in assisted conception: Study protocol for a randomized controlled trial

Trials

Volumn 13, Issue , 2012, Pages

  Gazvani, Rafet ^a   Russell, Richard ^a   Sajjad, Yasmin ^b   Alfirevic, Zarko ^c  

^a LIVERPOOL WOMEN S HOSPITAL   (United Kingdom)

^b ST MARY S HOSPITAL   (United Kingdom)

^c UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

IVF; Luteal phase; Progesterone; Support

Indexed keywords

ACTIVIN A; BUSERELIN ACETATE; CHORIONIC GONADOTROPIN BETA SUBUNIT; ESTRADIOL; INHIBIN A; INHIBIN B; PLACEBO; PREGNANCY ASSOCIATED PLASMA PROTEIN A; PROGESTERONE;

ARTICLE; BIOCHEMISTRY; BLOOD SAMPLING; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; EMBRYO TRANSFER; ESTRADIOL BLOOD LEVEL; FEMALE; FERTILIZATION IN VITRO; FETUS HEART RATE; FIRST TRIMESTER PREGNANCY; GESTATIONAL AGE; HUMAN; INFERTILITY THERAPY; OOCYTE RETRIEVAL; OUTCOME ASSESSMENT; PATIENT COMPLIANCE; PREGNANCY RATE; PREGNANCY TEST; PRENATAL DIAGNOSIS; PRESCRIPTION; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; TRANSVAGINAL ECHOGRAPHY; TREATMENT DURATION; URINALYSIS;

ADMINISTRATION, INTRAVAGINAL; ADULT; CLINICAL PROTOCOLS; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; EMBRYO IMPLANTATION; EMBRYO TRANSFER; ENGLAND; FEMALE; FERTILITY AGENTS, FEMALE; FERTILIZATION IN VITRO; HUMANS; LUTEAL PHASE; OOCYTE RETRIEVAL; PESSARIES; PREGNANCY; PREGNANCY RATE; PREGNANCY TESTS; PROGESTERONE; PROSPECTIVE STUDIES; REPRODUCTIVE TECHNIQUES, ASSISTED; RESEARCH DESIGN; TIME FACTORS; TREATMENT OUTCOME; ULTRASONOGRAPHY, PRENATAL;

EID: 84864147497     PISSN: None     EISSN: 17456215     Source Type: Journal    
DOI: 10.1186/1745-6215-13-118     Document Type: Article

References (24)

1. Edwards RG, Steptoe PC, Purdy JM. Establishing full-term human pregnancies using cleaving embryos grown in vitro. Br J Obstet Gynaecol 1980, 87:737-756. 10.1111/j.1471-0528.1980.tb04610.x, 6775685.
2. Smitz J, Bourgain C, Van Waesberghe L, Camus M, Devroey P, Van Steirteghem AC. A prospective randomized study on oestradiol valerate supplementation in addition to intravaginal micronized progesterone in buserelin and HMG induced superovulation. Hum Reprod 1993, 8:40-45.
3. Smitz J, Erard P, Camus M, Devroey P, Tournaye H, Wisanto A, Van Steirteghem AC. Pituitary gonadotrophin secretory capacity during the luteal phase in superovulation using GnRH-agonists and HMG in a desensitization or flare-up protocol. Hum Reprod 1992, 7:1225-1229.
4. Ludwig M, Diedrich K. Evaluation of an optimal luteal phase support protocol in IVF. Acta Obstet Gynecol Scand 2001, 80:452-466. 10.1034/j.1600-0412.2001.080005452.x, 11328224.
5. Broekmans FJ, Bernardus RE, Berkhout G, Schoemaker J. Pituitary and ovarian suppression after early follicular and mid-luteal administration of a LHRH agonist in a depot formulation: decapeptyl CR. Gynecol Endocrinol 1992, 6:153-161. 10.3109/09513599209015549, 1442160.
6. Smitz J, Devroey P, Camus M, Deschacht J, Khan I, Staessen C, Van Waesberghe L, Wisanto A, Van Steirteghem AC. The luteal phase and early pregnancy after combined GnRH-agonist/HMG treatment for superovulation in IVF or GIFT. Hum Reprod 1988, 3:585-590.
7. Daya S, Gunby J. Luteal phase support in assisted reproduction cycles. The Cochrane Library 2004, NJ, USA: John Wiley and Sons Ltd.
8. Abramowicz JS, Archer DF. Uterine endometrial peristalsis - a transvaginal ultrasound study. Fertil Steril 1990, 54:451-454.
9. Fanchin R, Righini C, Olivennes F, Taylor S, de Ziegler D, Frydman R. Uterine contractions at the time of embryo transfer alter pregnancy rates after in-vitro fertilization. Hum Reprod 1998, 13:1968-1974. 10.1093/humrep/13.7.1968, 9740459.
10. Soliman S, Daya S, Collins J, Hughes EG. The role of luteal phase support in infertility treatment: a meta-analysis of randomized trials. Fertil Steril 1994, 61:1068-1076.
11. Penzias AS. Luteal phase support. Semin Reprod Endocrinol 1995, 13:32-38.
12. Herman A, Ron-El R, Golan A, Raziel A, Soffer Y, Caspi E. Pregnancy rate and ovarian hyperstimulation after luteal human chorionic gonadotropin in in vitro fertilization stimulated with gonadotropin-releasing hormone analog and menotropins. Fertil Steril 1990, 53:92-96.
13. Arafat ES, Hargrove JT, Maxson WS, Desiderio DM, Wentz AC, Andersen RN. Sedative and hypnotic effects of oral administration of micronized progesterone may be mediated through its metabolites. Am J Obstet Gynecol 1988, 159:1203-1209.
14. Friedler S, Raziel A, Schachter M, Strassburger D, Bukovsky I, Ron-El R. Luteal support with micronized progesterone following in-vitro fertilization using a down-regulation protocol with gonadotrophin-releasing hormone agonist: a comparative study between vaginal and oral administration. Hum Reprod 1999, 14:1944-1948. 10.1093/humrep/14.8.1944, 10438404.
15. Licciardi FL, Kwiatkowski A, Noyes NL, Berkeley AS, Krey LL, Grifo JA. Oral versus intramuscular progesterone for in vitro fertilization: a prospective randomized study. Fertil Steril 1999, 71:614-618. 10.1016/S0015-0282(98)00515-9, 10202868.
16. Bourgain C, Devroey P, Van Waesberghe L, Smitz J, Van Steirteghem AC. Effects of natural progesterone on the morphology of the endometrium in patients with primary ovarian failure. Hum Reprod 1990, 5:537-543.
17. Devroey P, Palermo G, Bourgain C, Van Waesberghe L, Smitz J, Van Steirteghem AC. Progesterone administration in patients with absent ovaries. Int J Fertil 1989, 34:188-193.
18. Smitz J, Devroey P, Faguer B, Bourgain C, Camus M, Van Steirteghem AC. A prospective randomized comparison of intramuscular or intravaginal natural progesterone as a luteal phase and early pregnancy supplement. Hum Reprod 1992, 7:168-175.
19. Kline DG, Kim D, Midha R, Harsh C, Tiel R. Management and results of sciatic nerve injuries: a 24-year experience. J Neurosurg 1998, 89:13-23. 10.3171/jns.1998.89.1.0013, 9647167.
20. Bulletti C, de Ziegler D, Flamigni C, Giacomucci E, Polli V, Bolelli G, Franceschetti F. Targeted drug delivery in gynaecology: the first uterine pass effect. Hum Reprod 1997, 12:1073-1079. 10.1093/humrep/12.5.1073, 9194669.
21. Cicinelli E, de Ziegler D, Bulletti C, Matteo MG, Schonauer LM, Galantino P. Direct transport of progesterone from vagina to uterus. Obstet Gynecol 2000, 95:403-406. 10.1016/S0029-7844(99)00542-6, 10711552.
22. Fanchin R, De Ziegler D, Bergeron C, Righini C, Torrisi C, Frydman R. Transvaginal administration of progesterone. Obstet Gynecol 1997, 90:396-401. 10.1016/S0029-7844(97)00270-6, 9277651.
23. Nakajima ST, Nason FG, Badger GJ, Gibson M. Progesterone production in early pregnancy. Fertil Steril 1991, 55:516-521.
24. Wolf A, Wood EG, Batzer FR. The Luteo-placental shift: observation on its occurrence with Crinone treatment. Fertil Steril 1998, 70(Suppl 1):S396.a.