Lack of cytotoxic and genotoxic effects of Minthostachys verticillata essential oil: Studies in vitro and in vivo

Food and Chemical Toxicology

Volumn 50, Issue 9, 2012, Pages 3062-3067

  Escobar, Franco Matías ^a   Cariddi, Laura Noelia ^a   Sabini, María Carola ^a   Reinoso, Elina ^a   Sutil, Sonia Beatriz ^a   Torres, Cristina Vanesa ^a   Zanon, Silvia Matilde ^a   Sabini, Liliana Inés ^a  

^a DEPARTAMENTO DE QUÍMICA   (Argentina)

Author keywords

Apoptosis; Cytotoxicity; Essential oil; Gas chromatography; Genotoxicity; Minthostachys verticillata

Indexed keywords

4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; BETA PINENE; CINEOLE; CYCLOPHOSPHAMIDE; DNA; ESSENTIAL OIL; LIMONENE; MENTHONE; MINTHOSTACHYS VERTICILLATA ESSENTIAL OIL; PINENE; PULEGONE; TRYPAN BLUE; UNCLASSIFIED DRUG;

AGAR GEL ELECTROPHORESIS; ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BONE MARROW CELL; CELL ASSAY; CELL VIABILITY; CHEMICAL COMPOSITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG CYTOTOXICITY; DRUG DOSE COMPARISON; DRUG SAFETY; ERYTHROCYTE; FEMALE; GAS CHROMATOGRAPHY; GENOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MEDICINAL PLANT; MICRONUCLEUS TEST; MINTHOSTACHYS VERTICILLATA; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PHYTOCHEMISTRY; PLANT LEAF; PLANT STEM; SINGLE DRUG DOSE; TOXICITY TESTING; TRYPAN BLUE DYE EXCLUSION ASSAY; VERO CELL;

ANIMALS; APOPTOSIS; CARCINOGENICITY TESTS; CERCOPITHECUS AETHIOPS; CHROMATOGRAPHY, GAS; ELECTROPHORESIS, AGAR GEL; FEMALE; HUMANS; LAMIACEAE; MALE; MICE; MICE, INBRED BALB C; MUTAGENICITY TESTS; OILS, VOLATILE; VERO CELLS;

MINTHOSTACHYS VERTICILLATA; MUS;

EID: 84864144262     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2012.06.018     Document Type: Article

References (41)

1. Abdillahi H.S., Verschaeve L., Finnie J.F., Van Staden J. Mutagenicity, antimutagenicity and cytotoxicity evaluation of South African Podocarpus species. J. Ethnopharmacol. 2012, 139:728-738.
2. Amirghofran Z., Bahmani M., Azadmehr A., Javidnia K. Immunomodulatory and apoptotic effects of Stachys obtusicrena on proliferative lymphocytes. Med. Sci. Monit. 2007, 13:145-150.
3. Bakkali F., Averbeck S., Averbeck D., Zhiri A., Idaomar M. Cytotoxicity and gene induction by some essential oils in the yeast Saccharomyces cerevisiae. Mut. Res. 2005, 585:1-13.
4. Banchio E., Zygadlo J., Valladares G.R. Effects of mechanical wounding on essential oil composition and emission of volatiles from Minthostachys mollis. J. Chem. Ecol. 2005, 31:719-727.
5. Bandoni A.L., Mendiondo M.E., Rondina R.V.D., Coussio J.D. Survey of Argentine medicinal plants. I. Folklore and phytochemical screening. Lloydia 1972, 35:69-80.
6. Bluma R., Amaiden M.R., Daghero J., Etcheverry M. Control of Aspergillus section Flavi growth and aflatoxin accumulation by plant essential oils. J. Appl. Microbiol. 2008, 105:203-214.
7. Bonzani N., Ariza Espinar L. Estudios anatómicos de tres especies de Lamiaceae usadas en medicina popular. Acta Farm. Bonaerense 1993, 12:113-123.
8. Borenfreund E., Puerner J.A. A simple quantitative procedure using monolayer cultures for cytotoxicity assays (HTD/NR-90). Methods Cell Sci. 1985, 9:7-9.
9. Cariddi L.N., Panero A., Demo M.S., Sabini L.I., Maldonado A.M., Grosso M., Zyglado J. Inhibition of immediate-type allergic reaction by Minthostachys verticillata (Griseb.) Epling essential oil. J. Essent. Oil Res. 2007, 19:190-196.
10. Cariddi L.N., Escobar F., Moser M., Panero A., Alaniz F., Zygadlo J., Sabini L., Maldonado A. Monoterpenes isolated from Minthostachys verticillata (Griseb.) Epling essential oil modulates immediate-type hypersensitivity responses in vitro and in vivo. Planta Med. 2011, 77:1687-1694.
11. De Feo V., Ricciardi A., Biscardi D. Chemical composition and antimicrobial screening of the essential oil of Minthostachys verticillata (Griseb.) Epl. (Lamiaceae). J. Essent. Oil Res. 1998, 10:61-65.
12. De Logu A., Loy G., Pellerano M.L., Bonsignore L., Schivo M.L. Inactivation of HSV-1 and HSV-2 and prevention of cell-to-cell virus spread by Santolina insularis essential oil. Antiviral Res. 2000, 48:177-185.
13. Fentem J.H. The use of human tissues in vitro toxicology. Summary of general discussions. Hum. Exp. Toxicol. 1994, 13:445-449.
14. Fester G.A., Martinuzzi E.A. La esencia de peperina. 2a comunicación. An. Asoc. Quím. Argent. 1950, 38:255-267.
15. Fester, G.A., Martinuzzi, E.A., Retamar, J.A., Ricciardi, A.I.A., 1960. Estudios sobre esencias volátiles argentinas, vol. 29, Revista de la Facultad Ing Quim, Universidad Nacional del Litoral, Santa Fe, Argentina, pp. 21-44.
16. Franzios G., Mirotsou M., Hatziapostolou E., Oral J., Scouras Z.G., Mavragani-Tsipidou P. Insecticidal and genotoxic activities of mint essential oils. J. Agric. Food Chem. 1997, 45:2690-2694.
17. González M.J., Marioli J.M. Antibacterial activity of water extracts and essential oils of various aromatic plants against Paenibacillus larvae, the causative agent of American Foulbrood. J. Invertebr. Pathol. 2010, 104:209-213.
18. González Pereyra M.L., Cariddi L.N., Ybarra F., Isola M.C., Demo M.S., Sabini L.I., Maldonado A.M. Immunomodulating properties of Minthostachys verticillata on human lymphocytes and basophils. Rev. Alerg. Mex. 2005, 52:105-112.
19. Krishna G., Hayashi M. In vivo rodent micronucleus assay: protocol, conduct and data interpretation. Mut. Res. 2000, 455:155-166.
20. Kuttan G., Pratheeshkumar P., Manu K.A., Kuttan R. Inhibition of tumor progression by naturally occurring terpenoids. Pharm. Biol. 2011, 49:995-1007.
21. Lu X.G., Zhan L.B., Feng B.A., Qu M.Y., Yu L.H., Xie J.H. Inhibition of growth and metastasis of human gastric cancer implanted in nude mice by d-limonene. World J. Gastroenterol. 2004, 10:2140-2144.
22. Maldonado A.M., Calvo D., Cariddi L.N., Demo M. Efectos linfoproliferativos y antimicrobianos de productos vegetales derivados de Minthostachys verticillata y Achyrocline satureioides. Archivos de Alergia e Inmunología Clínica 2001, 32:82.
23. Militão G.C.G., Dantas I.N.F., Pessoa C., Falcão M.J.C., Silveira E.R., Lima M.A.S., Curi R., Lima T., Moraes M.O., Costa-Lotufo L.V. Induction of apoptosis by pterocarpans from Platymiscium floribundum in HL-60 human leukemia cells. Life Sci. 2006, 78:2409-2417.
24. Mongini C., Waldner C. Metodologías para la evaluación de las células inmunocompetentes. Inmunología e Inmunoquímica 1996, 730-734. Editorial Médica Panamericana, Argentina. R.A. Margni (Ed.).
25. Montaner B., Navarro S., Piqué M., Vilaseca M., Martinell M., Giralt E., Gil J., Pérez-Tomás R. Prodigiosin from the supernatant of Serratia marcescens induces apoptosis in haematopoietic cancer cell lines. Brit. J. Pharmacol. 2000, 131:585-593.
26. Nair B. Final report on the safety assessment of Mentha Piperita (Peppermint) Oil, Mentha Piperita (Peppermint) Leaf Extract, Mentha Piperita (Peppermint) Leaf, and Mentha Piperita (Peppermint) Leaf Water. Int. J. Toxicol. 2001, 20:61-63.
27. Nakaizumi A., Baba M., Uehara H., Iishi H., Tatsuta M. D-Limonene inhibits N-nitrosobis(2-oxopropyl)amine induced hamster pancreatic carcinogenesis. Cancer Lett. 1997, 117:99-103.
28. Núñez, C.M., Cantero, J.J., 2000. Las plantas medicinales del Sur de la provincia de Córdoba. (Ed.), De la Fundación Universidad Nacional de Río Cuarto, Argentina, pp. 1-144.
29. Ojeda M., Coirini R., Cosiansi J., Zapata R., Zygadlo J. Evaluation of variability in natural populations of peperina (Minthostachys mollis (Kunth.) Griseb.), an aromatic species from Argentina. Plant Genet. Resour. Newsl. 2001, 126:27-30.
30. Palacios S.M., Bertoni A., Rossi Y., Santander R., Urzúa A. Insecticidal activity of essential oils from native medicinal plants of Central Argentina against the house fly, Musca domestica (L). Parasitol. Res. 2009, 106:207-212.
31. Pavlidou V., Karpouhtsis I., Franzios G., Zambetaki A., Scouras Z., Mavragani-Tsipidou P. Insecticidal and genotoxic effects of essential oils of Greek sage, Salvia fruticosa, and Mint, Mentha pulegium, on Drosophila melanogaster and Bactrocera oleae (Diptera: Tephritidae). J. Agric. Urban Entomol. 2004, 21:39-49.
32. Primo V., Rovera M., Zanon S., Oliva M., Demo M., Daghero J., Sabini L. Determination of the antibacterial and antiviral activity of the essential oil from Minthostachys verticillata (Griseb.) Epling. Rev. Argent. Microbiol. 2001, 33:113-117.
33. Rabi T., Bishayee A. d-limonene sensitizes docetaxel-induced cytotoxicity in human prostate cancer cells: generation of reactive oxygen species and induction of apoptosis. J. Carcinogr. 2009, 8. art. no. 9.
34. Rossi Y.E., Canavoso L., Palacios S.M. Molecular response of Musca domestica L. to Mintostachys verticillata essential oil, (4R)(+)-pulegone and menthone. Fitoterapia 2012, 83:336-342.
35. 50 and repellent effects of essential oils from Argentinean wild plant species on Varroa destructor. J. Econ. Entomol. 2005, 98:651-655.
36. Schmid W. The micronucleus test. Mut. Res. 1975, 31:9-15.
37. Schmidt-Lebuhn A.N. Ethnobotany, biochemistry and pharmacology of Minthostachys (Lamiaceae). J. Ethnopharmacol. 2008, 118:343-353.
38. Sun J. d-limonene: safety and clinical applications. Altern. Med. Rev. 2007, 12:259-264.
39. Sutil S.B., Astesano A., Vogt V., Torres C.V., Zanon S.M., Sabini L.I. Minthostachys verticillata: toxicity of its essential oil and major constituents to Artemia salina and cell lines. Mol. Med. Chem. 2006, 10:41-42.
40. Zhou S.F., Xue C.C., Yu X.Q., Wang G. Metabolic activation of herbal and dietary constituents and its clinical and toxicological implications: an update. Curr. Drug Metab. 2007, 8:526-553.
41. Zygadlo J., Maestri D., Lamarque A., Guzmán C., Velasco-Negueruela A., Pérez-Alonso M., García-Vallejos M., Grosso N. Essential oil variability of Minthostachys verticillata. Biochem. Syst. Ecol. 1996, 24:319-323.