CD31+ cell percentage correlation with speed of CD4+ T-cell count recovery in HIV-infected adults is reversed in children: Higher thymic output may be responsible

Clinical Infectious Diseases

Volumn 55, Issue 2, 2012, Pages 304-307

  Lewis, Joanna ^a,b   Sarah Walker, A ^b   Klein, Nigel ^a   Callard, Robin ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CD31 ANTIGEN;

CD4 LYMPHOCYTE COUNT; CD4 LYMPHOCYTE PERCENTAGE; CD4+ T LYMPHOCYTE; CELL DEATH; CORRELATION ANALYSIS; DISEASE ASSOCIATION; FLOW CYTOMETRY; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LETTER; PRIORITY JOURNAL; THYMUS; VIRUS LOAD;

ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4-POSITIVE T-LYMPHOCYTES; FEMALE; HIV INFECTIONS; HUMANS; MALE; THYMUS GLAND;

EID: 84864136069     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/cis374     Document Type: Letter

References (7)

1. Li T, Wu N, Dai Y, et al. Reduced thymic output is a major mechanism of immune reconstitution failure in hiv-infected patients after long-term antiretroviral therapy. Clin Infect Dis 2011; 53:944-51.
2. Bains I, Thiebaut R, Yates AJ, Callard R. Quantifying thymic export: combining models of naive T cell proliferation and TCR excision circle dynamics gives an explicit measure of thymic output. J Immunol 2009; 183:4329-36.
3. Dutilh BE, de Boer RJ. Decline in excision circles requires homeostatic renewal or homeostatic death of naive T cells. J Theor Biol 2003; 224:351-8. (Pubitemid 37297431)
4. Surh CD, Sprent J. Homeostasis of Naive and Memory T Cells. Immunity 2008; 29:848-62.
5. Huenecke S, Behl M, Fadler C, et al. Agematched lymphocyte subpopulation reference values in childhood and adolescence: application of exponential regression analysis. Eur J Haematol 2008; 80:532-9. (Pubitemid 351677456)
6. R Development Core Team. R: a language and environment for statistical computing. Vienna, Austria: Vienna, Austria: R Foundation for Statistical Computing, 2011.
7. Pinheiro J, Bates D, DebRoy S, Sarkar D, R Development Core Team. nlme: linear and nonlinear mixed effects models. Vienna, Austria: R Foundation for Statistical Computing, 2011.