High-dose atorvastatin enhances impaired cerebral vasomotor reactivity

Journal of Stroke and Cerebrovascular Diseases

Volumn 21, Issue 6, 2012, Pages 487-492

  Forteza, Alejandro ^a   Romano, Jose G ^b   Campo Bustillo, Iszet ^b   Campo, Nelly ^b   Haussen, Diogo C ^b   Gutierrez, Jose ^b   Koch, Sebastian ^b  

^a JACKSON MEMORIAL HOSPITAL   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Cerebrovascular reactivity; statins HMG CoA; transcranial Doppler

Indexed keywords

ATORVASTATIN; CREATINE KINASE; LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; ARTICLE; BLOOD VESSEL REACTIVITY; CEREBROVASCULAR DISEASE; CLINICAL ARTICLE; CREATINE KINASE BLOOD LEVEL; DOPPLER ECHOGRAPHY; DRUG DOSE REDUCTION; DRUG MECHANISM; DRUG MEGADOSE; DYSLIPIDEMIA; FEMALE; HUMAN; HYPERTENSION; HYPERTRANSAMINASEMIA; MALE; MIDDLE CEREBRAL ARTERY; MYALGIA; PRIORITY JOURNAL; SIDE EFFECT; VASOMOTOR DISORDER; VASOMOTOR REFLEX; WEAKNESS;

AGED; ANTIHYPERTENSIVE AGENTS; BIOLOGICAL MARKERS; BLOOD FLOW VELOCITY; BLOOD PRESSURE; BRAIN INFARCTION; CEREBROVASCULAR CIRCULATION; CHI-SQUARE DISTRIBUTION; CHOLESTEROL, LDL; FEMALE; FLORIDA; HEMODYNAMICS; HEPTANOIC ACIDS; HISPANIC AMERICANS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERCHOLESTEROLEMIA; HYPERTENSION; MALE; MIDDLE AGED; MIDDLE CEREBRAL ARTERY; PROSPECTIVE STUDIES; PYRROLES; TIME FACTORS; TREATMENT OUTCOME; ULTRASONOGRAPHY, DOPPLER, TRANSCRANIAL;

EID: 84864123561     PISSN: 10523057     EISSN: 15328511     Source Type: Journal    
DOI: 10.1016/j.jstrokecerebrovasdis.2010.12.002     Document Type: Article

References (21)

1. E. Troisi, A. Attanasio, and M. Matteis Cerebral hemodynamics in young hypertensive subjects and effects of atenolol treatment J Neurol Sci 159 1998 115 119
2. C.M. Molina, J.A.M. Sabin, and J.M. Montaner Impaired cerebrovascular reactivity as a risk marker for first-ever lacunar infarction: A case-control study Stroke 30 1999 2296 2301
3. S.L.M. Bakker, F.E. de Leeuw, and J.C. de Groot Cerebral vasomotor reactivity and cerebral white matter lesions in the elderly Neurology 52 1999 578 583
4. G. Settakis, D. Pall, and C. Molnar Cerebrovascular reactivity in hypertensive and healthy adolescents: TCD with vasodilatory challenge J Neuroimag 13 2003 106 112
5. D.R. Harder Pressure-induced myogenic activation of cat cerebral arteries is dependent on intact endothelium Circ Res 60 1987 102 107
6. R.F. Furchgott, and J.V. Zawadzki The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine Nature 288 1980 373 376
7. S.T. Yang, W.G. Mayhan, and W.M. Faraci Endothelium-dependent responses of cerebral blood vessels during chronic hypertension Hypertension 17 1991 612 618
8. G.L. Baumbach, and D.D. Heistad Adaptive changes in cerebral blood vessels during chronic hypertension J Hypertens 9 1991 987 991
9. U. Laufs, V. La Fata, and J. Plutzky Up-regulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors Circulation 97 1998 1129 1135
10. P. Sterzer, F. Meintzschel, and A. Rosler Pravastatin improves cerebral vasomotor reactivity in patients with subcortical small-vessel disease Stroke 32 2001 2817 2820
11. K. Sander, U. Hof, and H. Poppert Improved cerebral vasoreactivity after statin administration in healthy adults Neuroimaging 15 2005 266 270
12. E.S.G. Stroes, H.A. Koomans, and T.W.A. de Bruin Vascular function in the forearm of hypercholesterolaemic patients off and on lipid-lowering medication Lancet 346 1995 467 471
13. W.-H. Leung, C.-P. Lau, and C-K. Wong Beneficial effect of cholesterol-lowering therapy on coronary endothelium-dependent relaxation in hypercholesterolaemic patients Lancet 341 1993 1496 1500
14. M. Murakami, S. Fujioka, and Y. Hirata Low-dose of statin treatment improves cerebrovascular reactivity in patients with ischemic stroke: single photon emission computed tomography analysis J Stroke Cerebrovasc Dis 17 2008 16 22
15. 2-induced cerebral vasomotor response in normal individuals and patients with internal carotid artery occlusions Stroke 19 1988 963 969
16. P.C. Lavallée, J. Labreuche, and F. Gongora-Rivera Lacunar-BICHAT Investigators. Placebo-controlled trial of high-dose atorvastatin in patients with severe cerebral small vessel disease Stroke 40 2009 1721 1728
17. A. Niruban, P.K. Myint, and J.F. Potter Placebo-controlled trial of high-dose atorvastatin in patients with severe cerebral small vessel disease Stroke 40 2009 e542
18. J. Pretnar-Oblak, M. Sabovic, and M. Sebestjen Influence of atorvastatin treatment on L-arginine cerebrovascular reactivity and flow-mediated dilatation in patients with lacunar infarctions Stroke 37 2006 2540 2545
19. A. Corsini, M. Mazzotti, and M. Raiteri Relationship between mevalonate pathway and arterial myocyte proliferation: In vitro studies with inhibitors of HMG-CoA reductase Atherosclerosis 101 1993 117 125
20. M. Crisby, G. Nordin-Fredricksson, and P.K. Shah Pravastatin treatment increases collagen content and decreases lipid content, inflammation, metalloproteinases, and cell death in human carotid plaques: Implications for plaque stabilization Circulation 103 2001 926 933
21. P. Amarenco, J. Bogousslavsky, and A. Callahan 3rd High-dose atorvastatin after stroke or transient ischemic attack N Engl J Med 355 2006 549 559