Transcriptional regulator Id2 is required for the CD4 T cell immune response in the development of experimental autoimmune encephalomyelitis

Journal of Immunology

Volumn 189, Issue 3, 2012, Pages 1400-1405

  Lin, Yen Yu ^a   Jones Mason, Mary E ^a   Inoue, Makoto ^a   Lasorella, Anna ^b   Iavarone, Antonio ^b   Li, Qi Jing ^a   Shinohara, Mari L ^a   Zhuang, Yuan ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b New York Presbyterian Morgan Stanley Children's Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIM PROTEIN; INHIBITOR OF DIFFERENTIATION 2; INTERLEUKIN 17; SUPPRESSOR OF CYTOKINE SIGNALING 3;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; EFFECTOR CELL; FLOW CYTOMETRY; KNOCKOUT MOUSE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE; LYMPHOCYTE PROLIFERATION; LYMPHOID ORGAN; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; SPLEEN CELL;

AMINO ACID SEQUENCE; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; G0 PHASE; GENE KNOCK-IN TECHNIQUES; HUMANS; INHIBITOR OF DIFFERENTIATION PROTEIN 2; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; TH17 CELLS; TRANSCRIPTION, GENETIC;

EID: 84864117109     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1200491     Document Type: Article

References (27)

1. Taylor, J. J., and M. K. Jenkins. 2011. CD4+ memory T cell survival. Curr. Opin. Immunol. 23: 319-323.
2. Joshi, N. S., W. Cui, A. Chandele, H. K. Lee, D. R. Urso, J. Hagman, L. Gapin, and S. M. Kaech. 2007. Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor. Immunity 27: 281-295.
3. Rutishauser, R. L., G. A. Martins, S. Kalachikov, A. Chandele, I. A. Parish, E. Meffre, J. Jacob, K. Calame, and S. M. Kaech. 2009. Transcriptional repressor Blimp-1 promotes CD8(+) T cell terminal differentiation and represses the acquisition of central memory T cell properties. Immunity 31: 296-308.
4. Kaech, S. M., J. T. Tan, E. J. Wherry, B. T. Konieczny, C. D. Surh, and R. Ahmed. 2003. Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat. Immunol. 4: 1191-1198.
5. Ji, Y., Z. Pos, M. Rao, C. A. Klebanoff, Z. Yu, M. Sukumar, R. N. Reger, D. C. Palmer, Z. A. Borman, P. Muranski, et al. 2011. Repression of the DNA-binding inhibitor Id3 by Blimp-1 limits the formation of memory CD8+ T cells. Nat. Immunol. 12: 1230-1237.
6. Yang, C. Y., J. A. Best, J. Knell, E. Yang, A. D. Sheridan, A. K. Jesionek, H. S. Li, R. R. Rivera, K. C. Lind, L. M. D'Cruz, et al. 2011. The transcriptional regulators Id2 and Id3 control the formation of distinct memory CD8+ T cell subsets. Nat. Immunol. 12: 1221-1229.
7. Cannarile, M. A., N. A. Lind, R. Rivera, A. D. Sheridan, K. A. Camfield, B. B. Wu, K. P. Cheung, Z. Ding, and A. W. Goldrath. 2006. Transcriptional regulator Id2 mediates CD8+ T cell immunity. Nat. Immunol. 7: 1317-1325.
8. Maruyama, T., J. Li, J. P. Vaque, J. E. Konkel, W. Wang, B. Zhang, P. Zhang, B. F. Zamarron, D. Yu, Y. Wu, et al. 2011. Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3. Nat. Immunol. 12: 86-95.
9. Miyazaki, M., R. R. Rivera, K. Miyazaki, Y. C. Lin, Y. Agata, and C. Murre. 2011. The opposing roles of the transcription factor E2A and its antagonist Id3 that orchestrate and enforce the naive fate of T cells. Nat. Immunol. 12: 992-1001.
10. Li, H., M. Dai, and Y. Zhuang. 2004. A T cell intrinsic role of Id3 in a mouse model for primary Sjogren's syndrome. Immunity 21: 551-560.
11. Kusunoki, T., M. Sugai, T. Katakai, Y. Omatsu, T. Iyoda, K. Inaba, T. Nakahata, A. Shimizu, and Y. Yokota. 2003. TH2 dominance and defective development of a CD8+ dendritic cell subset in Id2-deficient mice. J. Allergy Clin. Immunol. 111: 136-142.
12. Jones, M. E., and Y. Zhuang. 2007. Acquisition of a functional T cell receptor during T lymphocyte development is enforced by HEB and E2A transcription factors. Immunity 27: 860-870.
13. Schwartz, R., I. Engel, M. Fallahi-Sichani, H. T. Petrie, and C. Murre. 2006. Gene expression patterns define novel roles for E47 in cell cycle progression, cytokine-mediated signaling, and T lineage development. Proc. Natl. Acad. Sci. USA 103: 9976-9981.
14. Chen, X. P., J. A. Losman, and P. Rothman. 2000. SOCS proteins, regulators of intracellular signaling. Immunity 13: 287-290.
15. Yokota, Y., A. Mansouri, S. Mori, S. Sugawara, S. Adachi, S. Nishikawa, and P. Gruss. 1999. Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2. Nature 397: 702-706.
16. Jones-Mason, M. E., X. Zhao, D. Kappes, A. Lasorella, A. Iavarone, and Y. Zhuang. 2012. E protein transcription factors are required for the development of CD4(+) lineage T cells. Immunity 36: 348-361.
17. Niola, F., X. Zhao, D. Singh, A. Castano, R. Sullivan, M. Lauria, H. Nam, Y. Zhuang, R. Benezra, D. D. Bernardo, et al. 2012. Id proteins synchronize stemness and anchorage to the niche of neural stem cells. Nat. Cell Biol. 14: 477-487.
18. Matsushita, T., K. Yanaba, J. D. Bouaziz, M. Fujimoto, and T. F. Tedder. 2008. Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression. J. Clin. Invest. 118: 3420-3430.
19. Kebir, H., I. Ifergan, J. I. Alvarez, M. Bernard, J. Poirier, N. Arbour, P. Duquette, and A. Prat. 2009. Preferential recruitment of interferon-gamma- expressing TH17 cells in multiple sclerosis. Ann. Neurol. 66: 390-402.
20. Rice, G. P., H. P. Hartung, and P. A. Calabresi. 2005. Anti-alpha4 integrin therapy for multiple sclerosis: mechanisms and rationale. Neurology 64: 1336-1342.
21. Reboldi, A., C. Coisne, D. Baumjohann, F. Benvenuto, D. Bottinelli, S. Lira, A. Uccelli, A. Lanzavecchia, B. Engelhardt, and F. Sallusto. 2009. C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE. Nat. Immunol. 10: 514-523.
22. Baker, B. J., L. N. Akhtar, and E. N. Benveniste. 2009. SOCS1 and SOCS3 in the control of CNS immunity. Trends Immunol. 30: 392-400.
23. Liu, X., Y. S. Lee, C. R. Yu, and C. E. Egwuagu. 2008. Loss of STAT3 in CD4+ T cells prevents development of experimental autoimmune diseases. J. Immunol. 180: 6070-6076.
24. Kee, B. L. 2009. E and ID proteins branch out. Nat. Rev. Immunol. 9: 175-184.
25. Muranski, P., Z. A. Borman, S. P. Kerkar, C. A. Klebanoff, Y. Ji, L. Sanchez-Perez, M. Sukumar, R. N. Reger, Z. Yu, S. J. Kern, et al. 2011. Th17 cells are long lived and retain a stem cell-like molecular signature. Immunity 35: 972-985.
26. Spolski, R., and W. J. Leonard. 2008. The Yin and Yang of interleukin-21 in allergy, autoimmunity and cancer. Curr. Opin. Immunol. 20: 295-301.
27. Hirota, K., J. H. Duarte, M. Veldhoen, E. Hornsby, Y. Li, D. J. Cua, H. Ahlfors, C. Wilhelm, M. Tolaini, U. Menzel, et al. 2011. Fate mapping of IL-17-producing T cells in inflammatory responses. Nat. Immunol. 12: 255-263.