Obesity aggravates the joint inflammation in a collagen-induced arthritis model through deviation to Th17 differentiation

Experimental and Molecular Medicine

Volumn 44, Issue 7, 2012, Pages 424-431

  Jhun, Joo Yeon ^a   Yoon, Bo Young ^c   Park, Mi Kyung ^a   Oh, Hye Joa ^a   Byun, Jae Kyeong ^a   Lee, Seon Young ^a   Min, Jun Ki ^a   Park, Sung Hwan ^b   Kim, Ho Youn ^b   Cho, Mi La ^a  

^a The Catholic University of Korea   (South Korea)

^b The Catholic University of Korea   (South Korea)

^c Inje University   (South Korea)

Author keywords

Arthritis; Experimental; Inflammation; Mice; Obesity; Th17 cells

Indexed keywords

AUTOANTIBODY; COLLAGEN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G2A; INTERLEUKIN 17; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTHRITIS; ARTICLE; CELL COUNT; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; IMMUNOPATHOGENESIS; INCIDENCE; INFLAMMATION; LYMPHOCYTE DIFFERENTIATION; MIXED LYMPHOCYTE REACTION; MOUSE; NONHUMAN; OBESITY; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS; SCORING SYSTEM; SPLEEN CELL; SYNOVIUM; TH17 CELL;

MURINAE; MUS;

EID: 84864095554     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.3858/emm.2012.44.7.047     Document Type: Article

References (26)

1. Andersson N, Strandberg L, Nilsson S, Adamovic S, Karlsson MK, Ljunggren O, Mellstrom D, Lane NE, Zmuda JM, Nielsen C, Orwoll E, Loretzon M, Ohlsson C, Jansson JO. A variant near the interleukin-6 gene is associated with fat mass in Caucasian men. Int J Obes 2010;34:1011-9
2. Bokarewa M, Nagaev I, Dahlberg L, Smith U, Tarkowski A. Resistin, an adipokine with potent proinflammatory properties. J Immunol 2005;174:5789-95
3. Carman WJ, Sowers M, Hawthorne VM, Weissfeld LA. Obesity as a risk factor for osteoarthritis of the hand and wrist: a prospective study. Am J Epidemiol 1994;139:119-29
4. Croci T, Zarini E. Effect of the cannabinoid CB1 receptor antagonist rimonabant on nociceptive responses and adjuvant-induced arthritis in obese and lean rats. Br J Pharmacol 2007;150:559-66
5. Griffin TM, Fermor B, Huebner JL, Kraus VB, Rodriguiz RM, Wetsel WC, Cao L, Setton LA, Guilak F. Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice. Arthritis Res Ther 2010;12:R130
6. Grotle M, Hagen KB, Natvig B, Dahl FA, Kvien TK. Obesity and osteoarthritis in knee, hip and/or hand: an epidemiological study in the general population with 10 yr follow-up. BMC Musculoskelet Disord 2008;9:132
7. Iannone F, Lapadula G. Obesity and inflammation--targets for OA therapy. Curr Drug Targets 2010;11:586-98
8. Inglis JJ, Simelyte E, McCann FE, Criado G, Williams RO. Protocol for the induction of arthritis in C57BL/6 mice. Nat Protoc 2008;3:612-8
9. Ju JH, Cho ML, Jhun JY, Park MJ, Oh HJ, Min SY, Cho YG, Hwang SY, Kwok SK, Seo SH, Yoon CH, Park SH, Kim HY. Oral administration of type-II collagen suppresses IL-17-associated RANKL expression of CD4+T cells in collagen-induced arthritis. Immunol Lett 2008;117:16-25
10. Lubberts E, Koenders MI, Oppers-Walgreen B, van den Bersselaar L, Coenen-de Roo CJ, Joosten LA, van den Berg WB. Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion. Arthritis Rheum 2004;50:650-9
11. Malfait AM, Williams RO, Malik AS, Maini RN, Feldmann M. Chronic relapsing homologous collagen-induced arthritis in DBA/1 mice as a model for testing disease-modifying and remission-inducing therapies. Arthritis Rheum 2001;44: 1215-24
12. Matsui H, Tsutsumi A, Sugihara M, Suzuki T, Iwanami K, Kohno M, Goto D, Matsmoto I, Ito S, Sumida T. Visfatin (pre-B cell colony-enhancing factor) gene expression in patients with rheumatoid arthritis. Ann Rheum Dis 2008;67:571-2
13. Nakae S, Nambu A, Sudo K, Iwakura Y. Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice. J Immunol 2003;171:6173-7
14. Oliveria SA, Felson DT, Cirillo PA, Reed JI, Walker AM. Body weight, body mass index, and incident symptomatic osteoarthritis of the hand, hip, and knee. Epidemiology 1999; 10:161-6
15. Pedersen M, Jacobsen S, Klarlund M, Pedersen BV, Wiik A, Wohlfahrt J, Frisch M. Environmental risk factors differ between rheumatoid arthritis with and without autoantibodies against cyclic citrullinated peptides. Arthritis Res Ther 2006;8:R133
16. Rosloniec EF, Cremer M, Kang A, Myers LK. Collageninduced arthritis. In: Coligen JE, Kruisbeek AM, Margulies DH, Shevach EM, Strober W, editors. Current protocols in immunology 2001; Chapter 15: Unit 15.5.
17. Sarkar S, Cooney LA, White P, Dunlop DB, Endres J, Jorns JM, Wasco MJ, Fox DA. Regulation of pathogenic IL-17 responses in collagen-induced arthritis: roles of endogenous interferon-gamma and IL-4. Arthritis Res Ther 2009;11: R158
18. Senolt L, Housa D, Vernerová Z, Jirásek T, Svobodová R, Veigl D, Anderlova K, Muller-Ladner U, Pavelka K, Haluzik M. Resistin in rheumatoid arthritis synovial tissue, synovial fluid and serum. Ann Rheum Dis 2007;66:458-63
19. Seo JB, Choe SS, Jeong HW, Park SW, Shin HJ, Choi SM, Park JY, Choi EW, Kim JB, Seon DS, Jeong JY, Lee TG. Ant-obesity effects of Lysimachia foenum-graecum characterized by decreased adipogenesis and regulated lipid metabolism. Exp Mol Med 2011;43:205-15
20. Sumarac-Dumanovic M, Stevanovic D, Ljubic A, Jorga J, Simic M, Stamenkovic-Pejkovic D, Stracevic V, Trajkovic V, Micic D. Increased activity of interleukin-23/interleukin-17 proinflammatory axis in obese women. Int J Obes 2009;33: 151-6
21. Straburzyńska-Lupa A, Nowak A, Pilaczyńska-Szcześniak Ł, Straburzyńska-Migaj E, Romanowski W, Karolkiewicz J, Sliwicka E. Visfatin, resistin, hsCRP and insulin resistance in relation to abdominal obesity in women with rheumatoid arthritis. Clin Exp Rheumatol 2010;28:19-24
22. Stavropoulos-Kalinoglou A, Metsios GS, Panoulas VF, Nevill AM, Jamurtas AZ, Koutedakis Y, Kitas GD. Underweight and obese states both associate with worse disease activity and physical function in patients with established rheumatoid arthritis. Clin Rheumatol 2009;28:439-44
23. Symmons DP, Bankhead CR, Harrison BJ, Brennan P, Barrett EM, Scott DG, Silman AJ. Blood transfusion, smoking, and obesity as risk factors for the development of rheumatoid arthritis: results from a primary care-based incident case-control study in Norfolk, England. Arthritis Rheum 1997;40:1955-61
24. van der Helm-van Mil AH, van der Kooij SM, Allaart CF, Toes RE, Huizinga TW. A high body mass index has a protective effect on the amount of joint destruction in small joints in early rheumatoid arthritis. Ann Rheum Dis 2008;67:769-74
25. Voigt LF, Koepsell TD, Nelson JL, Dugowson CE, Daling JR. Smoking, obesity, alcohol consumption, and the risk of rheumatoid arthritis. Epidemiology 1994;5:525-32
26. Winer S, Paltser G, Chan Y, Tsui H, Engleman E, Winer D, Dosch HM. Obesity predisposes to Th17 bias. Eur J Immunol 2009;39:2629-35