Immunolocalization of DCAMKL-1, a putative intestinal stem cell marker, in normal colonic tissue

Pathology Research and Practice

Volumn 208, Issue 8, 2012, Pages 475-479

  Gagliardi, Giuseppe ^b   Moroz, Krzysztof ^a   Bellows, Charles F ^b  

^a Department of Pathology ^*  (United States)

^b TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Chromogranin A; DCAMKL 1; Enteroendocrine cells; Gastrointestinal stem cell; Immunohistochemistry; Lgr5

Indexed keywords

BIOLOGICAL MARKER; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE I; CELL MARKER; CHROMOGRANIN A; G PROTEIN COUPLED RECEPTOR; LEUCINE RICH REPEAT CONTAINING G PROTEIN COUPLED RECEPTOR 5; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CELL COMPARTMENTALIZATION; CELL SUBPOPULATION; CELLULAR DISTRIBUTION; COLON; COLORECTAL STEM CELL; CONTROLLED STUDY; CRYPT CELL; ENTEROENDOCRINE CELL; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOLOCALIZATION; IMMUNOREACTIVITY; MALE; NEUROSECRETORY CELL; NORMAL HUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; STEM CELL; TISSUE DISTRIBUTION;

ADULT; AGED; BIOLOGICAL MARKERS; BIOPSY; CELL COUNT; COLON; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INTESTINAL MUCOSA; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MIDDLE AGED; PARAFFIN EMBEDDING; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, G-PROTEIN-COUPLED; STEM CELLS;

EID: 84864076396     PISSN: 03440338     EISSN: 16180631     Source Type: Journal    
DOI: 10.1016/j.prp.2012.05.015     Document Type: Article

References (20)

1. Barker N., Bartfeld S., Clevers H. Tissue-resident adult stem cell populations of rapidly self-renewing organs. Cell Stem Cell 2010, 7:656-670.
2. Bezençon C., Fürholz A., Raymond F., Mansourian R., Métairon S., Le Coutre J., Damak S. Murine intestinal cells expressing Trpm5 are mostly brush cells and express markers of neuronal and inflammatory cells. J. Comp. Neurol. 2008, 509:514-525.
3. Bjerknes M., Khandanpour C., Möröy T., Fujiyama T., Hoshino M., Klisch T.J., Ding Q., Gan L., Wang J., Martín M.G., Cheng H. Origin of the brush cell lineage in the mouse intestinal epithelium. Dev. Biol. 2011, PMID: 22185794.
4. Gerbe F., van Es J.H., Makrini L., Brulin B., Mellitzer G., Robine S., Romagnolo B., Shroyer N.F., Bourgaux J.F., Pignodel C., Clevers H., Jay P. Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium. J. Cell Biol. 2011, 192:767-780.
5. Giannakis M., Stappenbeck T.S., Mills J.C., Leip D.G., Lovett M., Clifton S.W., Ippolito J.E., Glasscock J.I., Arumugam M., Brent M.R., Gordon J.I. Molecular properties of adult mouse gastric and intestinal epithelial progenitors in their niches. J. Biol. Chem. 2006, 281:11292-11300.
6. Gunawardene A.R., Corfe B.M., Staton C.A. Classification and functions of enteroendocrine cells of the lower gastrointestinal tract. Int. J. Exp. Pathol. 2011, 92:219-231.
7. Humphries A., Wright N.A. Colonic crypt organization and tumorigenesis. Nat. Rev. Cancer 2008, 8:415-424.
8. Lin P.T., Gleeson J.G., Corbo J.C., Flanagan L., Walsh C.A. DCAMKL1 encodes a protein kinase with homology to doublecortin that regulates microtubule polymerization. J. Neurosci. 2000, 20:9152-9161.
9. May R., Riehl T.E., Hunt C., Sureban S.M., Anant S., Houchen C.W. Identification of a novel putative gastrointestinal stem cell and adenoma stem cell marker, doublecortin and CaM kinase-like-1, following radiation injury and in adenomatous polyposis coli/multiple intestinal neoplasia mice. Stem Cells 2008, 26:630-637.
10. May R., Sureban S.M., Hoang N., Riehl T.E., Lightfoot S.A., Ramanujam R., Wyche J.H., Anant S., Houchen C.W. Doublecortin and CaM kinase-like-1 and leucine-rich-repeat-containing G-protein-coupled receptor mark quiescent and cycling intestinal stem cells, respectively. Stem Cells 2009, 27:2571-2579.
11. Morroni M., Cangiotti A.M., Cinti S. Brush cells in the human duodenojejunal junction: an ultrastructural study. J. Anat. 2007, 211:125-131.
12. Potten C.S., Kellett M., Rew D.A., Roberts S.A. Proliferation in human gastrointestinal epithelium using bromodeoxyuridine in vivo: data for different sites, proximity to a tumour, and polyposis coli. Gut 1992, 33:524-529.
13. Sangiorgi E., Capecchi M.R. Bmi1 is expressed in vivo in intestinal stem cells. Nat. Genet. 2008, 40:915-920.
14. Saqui-Salces M., Keeley T.M., Grosse A.S., Qiao X.T., El-Zaatari M., Gumucio D.L., Samuelson L.C., Merchant J.L. Gastric tuft cells express DCLK1 and are expanded in hyperplasia. Histochem. Cell Biol. 2011, 136:191-204.
15. Sei Y., Lu X., Liou A., Zhao X., Wank S.A. A stem cell marker-expressing subset of enteroendocrine cells resides at the crypt base in the small intestine. Am. J. Physiol. Gastrointest. Liver Physiol. 2011, 300:G345-G356.
16. Sureban S.M., May R., Mondalek F.G., Qu D., Ponnurangam S., Pantazis P., Anant S., Ramanujam R.P., Houchen C.W. Nanoparticle-based delivery of siDCAMKL-1 increases microRNA-144 and inhibits colorectal cancer tumor growth via a Notch-1 dependent mechanism. J. Nanobiotechnol. 2011, 9:40.
17. Sureban S.M., May R., Ramalingam S., Subramaniam D., Natarajan G., Anant S., Houchen C.W. Selective blockade of DCAMKL-1 results in tumor growth arrest by a Let-7a MicroRNA-dependent mechanism. Gastroenterology 2009, 137:649-659.
18. Vega K.J., May R., Sureban S.M., Lightfoot S.A., Qu D., Reed A., Weygant N., Ramanujam R., Souza R., Madhoun M., Whorton J., Anant S., Meltzer S., Houchen C.W. Identification of the putative intestinal stem cell marker DCAMKL-1 in Barrett's Esophagus and Esophageal Adenocarcinoma. J. Gastroenterol. Hepatol. 2011, PMID: 21916995.
19. Wang P., Hou S.X. Regulation of intestinal stem cells in mammals and Drosophila. J. Cell Physiol. 2010, 222:33-37.
20. Yu D.C., Bury J.P., Tiernan J., Waby J.S., Staton C.A., Corfe B.M. Short-chain fatty acid level and field cancerization show opposing associations with enteroendocrine cell number and neuropilin expression in patients with colorectal adenoma. Mol. Cancer 2011, 10:27.