Vanadium pentoxide: Use of relevant historical control data shows no evidence for a carcinogenic response in F344/N rats

Regulatory Toxicology and Pharmacology

Volumn 64, Issue 1, 2012, Pages 155-160

  Starr, Thomas B ^a   MacGregor, Judith A ^b   Ehman, Kimberly D ^c   Nikiforov, Andrey I ^c  

^a TBS Associates   (United States)

^b Toxicology Consulting Services   (United States)

^c Toxicology Regulatory Services   (United States)

Author keywords

Carcinogenic risk assessment; Historical controls; Vanadium pentoxide; Weight of evidence descriptor

Indexed keywords

VANADIUM PENTOXIDE;

ANIMAL EXPERIMENT; ARTICLE; CANCER CLASSIFICATION; CANCER INCIDENCE; CANCER RISK; CARCINOGEN TESTING; CARCINOGENIC ACTIVITY; CARCINOGENICITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FEMALE; LUNG ADENOMA; LUNG CARCINOMA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RISK ASSESSMENT; RISK FACTOR; TOXICITY TESTING;

ADENOCARCINOMA; ADENOMA; ADMINISTRATION, INHALATION; ANIMALS; CARCINOGENICITY TESTS; CARCINOGENS; DATA INTERPRETATION, STATISTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; LUNG NEOPLASMS; MALE; MICE; RATS; RATS, INBRED F344; SPECIES SPECIFICITY; TIME FACTORS; UNITED STATES; VANADIUM COMPOUNDS;

MUS; RATTUS;

EID: 84864072382     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2012.06.017     Document Type: Article

References (13)

1. ACGIH. 2009. Vanadium Pentoxide: TLV® Chemical Substances 7th Edition Documentation, 9. Available at http://www.acgih.org/store/ProductDetail.cfm?id=1323.
2. Assem F.L., Levy L.S. A review of current toxicological concerns on vanadium pentoxide and other vanadium compounds: Gaps in knowledge and directions for future research. J. Toxicol. Environ. Health Part B 2009, 12:289-306.
3. Daniel W.W. Applied Nonparametric Statistics 1978, Houghton Mifflin Company, Boston MA, 503 pp.
4. Harter H.L., Owen D.B. Selected Tables in Mathematical Statistics - Volume 1 1970, Markham Publishing Company, Chicago IL, 405 pp.
5. Haseman J.K., Ney E., Nyska A., Rao G.N. Effect of diet and animal care/housing protocols on body weight, survival, tumor incidences, and nephropathy severity of F344 rats in chronic studies. Toxicol. Pathol. 2003, 31:674-681.
6. IARC Cobalt in hard metals and cobalt sulfate, gallium arsenide, indium phosphide and vanadium pentoxide. IARC Monogr. Eval. Carcinog. Risks Hum. 2006, 86:227-292.
7. NTP. 2002. NTP Technical Report on the Toxicology and Carcinogenicity Studies of Vanadium Pentoxide (CAS NO. 1314-62-1) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). National Toxicology Program, Research Triangle Park NC. NTP TR 507, NIH Publication No. 03-4441, pp. 352, dated December 2002.
8. NTP. 2011. NTP Historical Controls Report - All Routes and Vehicles - F344/N Rats. National Toxicology Program, Research Triangle Park NC. pp. 85, dated May 2011.
9. Ress N.B., Chou B.J., Renne R.A., Dill J.A., Miller R.A., Roycroft J.H., Hailey J.R., Haseman J.K., Bucher J.R. Carcinogenicity of inhaled vanadium pentoxide in F344/N rats and B6C3F1 mice. Toxicol. Sci. 2003, 74:287-296.
10. Rondini E.A., Walter D.M., Bauer A.K. Vanadium pentoxide induces pulmonary inflammation and tumor promotion in a strain-dependent manner. Part Fibre Toxicol. 2010, 7(9). April 12.
11. Schuler D., Chevalier H.J., Merker M., Morgenthal K., Ravanat J.L., Sagelsdorff P., Walter M., Weber K., McGregor D. First steps toward an understanding of a mode of carcinogenic action for vanadium pentoxide. J. Toxicol. Pathol. 2011, 24(3):149-162.
12. Tarone R.E. Testing the goodness of fit of the binomial distribution. Biometrics 1979, 66:585-590.
13. USEPA. 2005. Guidelines for Carcinogen Risk Assessment. EPA/630/P-03/001F. US Environmental Protection Agency, Washington DC.