-
1
-
-
19944428353
-
Discovery of N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays
-
DOI 10.1021/jm049486a
-
Lombardo LJ, Lee FY, Chen P, Norris D, Barrish JC, Behnia K et al. Discovery of N-(2-chloro-6-methyl-phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays. J Med Chem 2004; 47: 6658-6661. (Pubitemid 40053752)
-
(2004)
Journal of Medicinal Chemistry
, vol.47
, Issue.27
, pp. 6658-6661
-
-
Lombardo, L.J.1
Lee, F.Y.2
Chen, P.3
Norris, D.4
Barrish, J.C.5
Behnia, K.6
Castaneda, S.7
Cornelius, L.A.M.8
Das, J.9
Doweyko, A.M.10
Fairchild, C.11
Hunt, J.T.12
Inigo, I.13
Johnston, K.14
Kamath, A.15
Kan, D.16
Klei, H.17
Marathe, P.18
Pang, S.19
Peterson, R.20
Pitt, S.21
Schieven, G.L.22
Schmidt, R.J.23
Tokarski, J.24
Wen, M.-L.25
Wityak, J.26
Borzilleri, R.M.27
more..
-
2
-
-
33644784776
-
An efficient rapid system for profiling the cellular activities of molecular libraries
-
DOI 10.1073/pnas.0511292103
-
Melnick JS, Janes J, Kim S, Chang JY, Sipes DG, Gunderson D et al. An efficient rapid system for profiling the cellular activities of molecular libraries. Proc Natl Acad Sci USA 2006; 103: 3153-3158. (Pubitemid 43346440)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.9
, pp. 3153-3158
-
-
Melnick, J.S.1
Janes, J.2
Kim, S.3
Chang, J.Y.4
Sipes, D.G.5
Gunderson, D.6
Jarnes, L.7
Matzen, J.T.8
Garcia, M.E.9
Hood, T.L.10
Beigi, R.11
Xia, G.12
Harig, R.A.13
Asatryan, H.14
Yan, S.F.15
Zhou, Y.16
Gu, X.-J.17
Saadat, A.18
Zhou, V.19
King, F.J.20
Shaw, C.M.21
Su, A.I.22
Downs, R.23
Gray, N.S.24
Schultz, P.G.25
Warmuth, M.26
Caldwell, J.S.27
more..
-
3
-
-
67349149693
-
Therapeutic concentrations of dasatinib inhibit in vitro osteoclastogenesis
-
Vandyke K, Dewar AL, Farrugia AN, Fitter S, Bik To L, Hughes TP et al. Therapeutic concentrations of dasatinib inhibit in vitro osteoclastogenesis. Leukemia 2009; 23: 994-997.
-
(2009)
Leukemia
, vol.23
, pp. 994-997
-
-
Vandyke, K.1
Dewar, A.L.2
Farrugia, A.N.3
Fitter, S.4
Bik To, L.5
Hughes, T.P.6
-
4
-
-
77953725855
-
Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia
-
Kantarjian H, Shah NP, Hochhaus A, Cortes J, Shah S, Ayala M et al. Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2010; 362: 2260-2270.
-
(2010)
N Engl J Med
, vol.362
, pp. 2260-2270
-
-
Kantarjian, H.1
Shah, N.P.2
Hochhaus, A.3
Cortes, J.4
Shah, S.5
Ayala, M.6
-
5
-
-
46949090042
-
Low bone density and decreased inhibin-B/FSH ratio in a boy treated with imatinib during puberty
-
DOI 10.1016/S0140-6736(08)61023-5, PII S0140673608610235
-
Mariani S, Giona F, Basciani S, Brama M, Gnessi L. Low bone density and decreased inhibin-B/FSH ratio in a boy treated with imatinib during puberty. Lancet 2008; 372: 111-112. (Pubitemid 351958458)
-
(2008)
The Lancet
, vol.372
, Issue.9633
, pp. 111-112
-
-
Mariani, S.1
Giona, F.2
Basciani, S.3
Brama, M.4
Gnessi, L.5
-
6
-
-
67349264054
-
Growth deceleration in a girl treated with imatinib
-
Kimoto T, Inoue M, Kawa K. Growth deceleration in a girl treated with imatinib. Int J Hematol 2009; 89: 251-252.
-
(2009)
Int J Hematol
, vol.89
, pp. 251-252
-
-
Kimoto, T.1
Inoue, M.2
Kawa, K.3
-
7
-
-
68049137764
-
Longitudinal growth retardation in a prepubertal girl with chronic myeloid leukemia on long-term treatment with imatinib
-
Schmid H, Jaeger BA, Lohse J, Suttorp M. Longitudinal growth retardation in a prepubertal girl with chronic myeloid leukemia on long-term treatment with imatinib. Haematologica 2009; 94: 1177-1179.
-
(2009)
Haematologica
, vol.94
, pp. 1177-1179
-
-
Schmid, H.1
Jaeger, B.A.2
Lohse, J.3
Suttorp, M.4
-
8
-
-
78650667444
-
Imatinib is efficient but has a negative impact on growth in children with previously untreated chronic myelogenous leukaemia (CML) in early chronic phase (CP): Results of the French national phase IV trial [abstract]
-
Millot F, Baruchel A, Guilhot J, Petit A, Leblanc T, Bertrand Y et al. Imatinib is efficient but has a negative impact on growth in children with previously untreated chronic myelogenous leukaemia (CML) in early chronic phase (CP): results of the French national phase IV trial [abstract]. Blood 2009; 114: 863.
-
(2009)
Blood
, vol.114
, pp. 863
-
-
Millot, F.1
Baruchel, A.2
Guilhot, J.3
Petit, A.4
Leblanc, T.5
Bertrand, Y.6
-
9
-
-
70450277310
-
Imatinib mesylate causes growth plate closure in vivo
-
Vandyke K, Dewar AL, Fitter S, Menicanin D, To LB, Hughes TP et al. Imatinib mesylate causes growth plate closure in vivo. Leukemia 2009; 23: 2155-2159.
-
(2009)
Leukemia
, vol.23
, pp. 2155-2159
-
-
Vandyke, K.1
Dewar, A.L.2
Fitter, S.3
Menicanin, D.4
To, L.B.5
Hughes, T.P.6
-
10
-
-
0030885581
-
Platelet derived growth factor stimulates chondrocyte proliferation but prevents endochondral maturation
-
Kieswetter K, Schwartz Z, Alderete M, Dean DD, Boyan BD. Platelet derived growth factor stimulates chondrocyte proliferation but prevents endochondral maturation. Endocrine 1997; 6: 257-264. (Pubitemid 27431396)
-
(1997)
Endocrine
, vol.6
, Issue.3
, pp. 257-264
-
-
Kieswetter, K.1
Schwartz, Z.2
Alderete, M.3
Dean, D.D.4
Boyan, B.D.5
-
11
-
-
0032764948
-
Effect of serum and platelet-derived growth factor on chondrocytes grown in collagen gels
-
Weiser L, Bhargava M, Attia E, Torzilli PA. Effect of serum and platelet-derived growth factor on chondrocytes grown in collagen gels. Tissue Eng 1999; 5: 533-544.
-
(1999)
Tissue Eng
, vol.5
, pp. 533-544
-
-
Weiser, L.1
Bhargava, M.2
Attia, E.3
Torzilli, P.A.4
-
12
-
-
0028877919
-
Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: A role for Src family kinases
-
Calalb MB, Polte TR, Hanks SK. Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases. Mol Cell Biol 1995; 15: 954-963.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 954-963
-
-
Calalb, M.B.1
Polte, T.R.2
Hanks, S.K.3
-
13
-
-
0037059836
-
Focal adhesion kinase and mitogen-activated protein kinases are involved in chondrocyte activation by the 29-kDa amino-terminal fibronectin fragment
-
DOI 10.1074/jbc.M109690200
-
Gemba T, Valbracht J, Alsalameh S, Lotz M. Focal adhesion kinase and mitogen-activated protein kinases are involved in chondrocyte activation by the 29-kDa amino-terminal fibronectin fragment. J Biol Chem 2002; 277: 907-911. (Pubitemid 34968833)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.2
, pp. 907-911
-
-
Gemba, T.1
Valbracht, J.2
Alsalameh, S.3
Lotz, M.4
-
14
-
-
52749087495
-
Rho-ROCK signaling differentially regulates chondrocyte spreading on fibronectin and bone sialoprotein
-
DOI 10.1152/ajpcell.00548.2007
-
Gill KS, Beier F, Goldberg HA. Rho-ROCK signaling differentially regulates chondrocyte spreading on fibronectin and bone sialoprotein. Am J Physiol Cell Physiol 2008; 295: C38-C49. (Pubitemid 352755815)
-
(2008)
American Journal of Physiology - Cell Physiology
, vol.295
, Issue.1
-
-
Gill, K.S.1
Beier, F.2
Goldberg, H.A.3
-
15
-
-
0026023289
-
Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice
-
Soriano P, Montgomery C, Geske R, Bradley A. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell 1991; 64: 693-702. (Pubitemid 121001157)
-
(1991)
Cell
, vol.64
, Issue.4
, pp. 693-702
-
-
Soriano, P.1
Montgomery, C.2
Geske, R.3
Bradley, A.4
-
16
-
-
77955750697
-
The tyrosine kinase inhibitor dasatinib dysregulates bone remodeling through inhibition of osteoclasts in vivo
-
Vandyke K, Dewar AL, Diamond P, Fitter S, Schultz CG, Sims NA et al. The tyrosine kinase inhibitor dasatinib dysregulates bone remodeling through inhibition of osteoclasts in vivo. J Bone Miner Res 2010; 25: 1759-1770.
-
(2010)
J Bone Miner Res
, vol.25
, pp. 1759-1770
-
-
Vandyke, K.1
Dewar, A.L.2
Diamond, P.3
Fitter, S.4
Schultz, C.G.5
Sims, N.A.6
-
17
-
-
77953229623
-
Src family kinase/abl inhibitor dasatinib suppresses proliferation and enhances differentiation of osteoblasts
-
Lee YC, Huang CF, Murshed M, Chu K, Araujo JC, Ye X et al. Src family kinase/abl inhibitor dasatinib suppresses proliferation and enhances differentiation of osteoblasts. Oncogene 2010; 29: 3196-3207.
-
(2010)
Oncogene
, vol.29
, pp. 3196-3207
-
-
Lee, Y.C.1
Huang, C.F.2
Murshed, M.3
Chu, K.4
Araujo, J.C.5
Ye, X.6
-
18
-
-
77953559069
-
The Src inhibitor dasatinib accelerates the differentiation of human bone marrow-derived mesenchymal stromal cells into osteoblasts
-
Id Boufker H, Lagneaux L, Najar M, Piccart M, Ghanem G, Body JJ et al. The Src inhibitor dasatinib accelerates the differentiation of human bone marrow-derived mesenchymal stromal cells into osteoblasts. BMC Cancer 2010; 10: 298.
-
(2010)
BMC Cancer
, vol.10
, pp. 298
-
-
Id Boufker, H.1
Lagneaux, L.2
Najar, M.3
Piccart, M.4
Ghanem, G.5
Body, J.J.6
-
19
-
-
52749087495
-
Rho-ROCK signaling differentially regulates chondrocyte spreading on fibronectin and bone sialoprotein
-
DOI 10.1152/ajpcell.00548.2007
-
Gill KS, Beier F, Goldberg HA. Rho-ROCK signaling differentially regulates chondrocyte spreading on fibronectin and bone sialoprotein. Am J Physiol Cell Physiol 2008; 295: C38-C49. (Pubitemid 352755815)
-
(2008)
American Journal of Physiology - Cell Physiology
, vol.295
, Issue.1
-
-
Gill, K.S.1
Beier, F.2
Goldberg, H.A.3
-
20
-
-
0026023289
-
Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice
-
Soriano P, Montgomery C, Geske R, Bradley A. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell 1991; 64: 693-702. (Pubitemid 121001157)
-
(1991)
Cell
, vol.64
, Issue.4
, pp. 693-702
-
-
Soriano, P.1
Montgomery, C.2
Geske, R.3
Bradley, A.4
-
21
-
-
77955750697
-
The tyrosine kinase inhibitor dasatinib dysregulates bone remodeling through inhibition of osteoclasts in vivo
-
Vandyke K, Dewar AL, Diamond P, Fitter S, Schultz CG, Sims NA et al. The tyrosine kinase inhibitor dasatinib dysregulates bone remodeling through inhibition of osteoclasts in vivo. J Bone Miner Res 2010; 25: 1759-1770.
-
(2010)
J Bone Miner Res
, vol.25
, pp. 1759-1770
-
-
Vandyke, K.1
Dewar, A.L.2
Diamond, P.3
Fitter, S.4
Schultz, C.G.5
Sims, N.A.6
-
22
-
-
77953229623
-
Src family kinase/abl inhibitor dasatinib suppresses proliferation and enhances differentiation of osteoblasts
-
Lee YC, Huang CF, Murshed M, Chu K, Araujo JC, Ye X et al. Src family kinase/abl inhibitor dasatinib suppresses proliferation and enhances differentiation of osteoblasts. Oncogene 2010; 29: 3196-3207.
-
(2010)
Oncogene
, vol.29
, pp. 3196-3207
-
-
Lee, Y.C.1
Huang, C.F.2
Murshed, M.3
Chu, K.4
Araujo, J.C.5
Ye, X.6
-
23
-
-
77953559069
-
The Src inhibitor dasatinib accelerates the differentiation of human bone marrow-derived mesenchymal stromal cells into osteoblasts
-
Id Boufker H, Lagneaux L, Najar M, Piccart M, Ghanem G, Body JJ et al. The Src inhibitor dasatinib accelerates the differentiation of human bone marrow-derived mesenchymal stromal cells into osteoblasts. BMC Cancer 2010; 10: 298.
-
(2010)
BMC Cancer
, vol.10
, pp. 298
-
-
Id Boufker, H.1
Lagneaux, L.2
Najar, M.3
Piccart, M.4
Ghanem, G.5
Body, J.J.6
|