Is KRAS mutation associated with interval colorectal cancers?

Digestive Diseases and Sciences

Volumn 57, Issue 4, 2012, Pages 913-917

  Shaukat, Aasma ^a,b   Arain, Mustafa ^a,b   Anway, Ruth ^a,b   Manaktala, Sharad ^c   Pohlman, Laurie ^a   Thyagarajan, Bharat ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Cancer; Colorectal; Colorectal cancer; Interval; KRAS; Microsatellite instability; MSI

Indexed keywords

B RAF KINASE; K RAS PROTEIN;

AGED; ARTICLE; CANCER GROWTH; CANCER REGISTRY; CANCER STAGING; CANCER SURVIVAL; CHROMOSOMAL INSTABILITY; CODON; COLONOSCOPY; COLORECTAL CANCER; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GENE FREQUENCY; GENE LOCUS; GENE SEQUENCE; GENETIC ASSOCIATION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE INSTABILITY; PRIORITY JOURNAL; SURVIVAL TIME;

AGED; COLONOSCOPY; COLORECTAL NEOPLASMS; HUMANS; MALE; MICROSATELLITE INSTABILITY; MUTATION; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS B-RAF; RAS PROTEINS;

EID: 84864047254     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-011-1974-6     Document Type: Article

References (11)

1. Santini D, Loupakis F, Vincenzi B, et al. High concordance of kras status between primary colorectal tumors and related metastatic sites: implications for clinical practice. Oncologist. 2008; 13:1270-1275.
2. Liu X, Jakubowski M, Hunt JL. Kras gene mutation in colorectal cancer is correlated with increased proliferation and spontaneous apoptosis. Am J Clin Pathol. 2011;135:245-252.
3. Pino MS, Chung DC. The chromosomal instability pathway in colon cancer. Gastroenterology. 2010;138:2059-2072.
4. Walther A, Houlston R, Tomlinson I. Association between chromosomal instability and prognosis in colorectal cancer: a meta-analysis. Gut. 2008;57:941-950.
5. Sawhney MS, Farrar WD, Gudiseva S, et al. Microsatellite instability in interval colon cancers. Gastroenterology. 2006;131: 1700-1705.
6. Shaukat A, Arain M, Thaygarajan B, Bond JH, Sawhney M. Is braf mutation associated with interval colorectal cancers? Dig Dis Sci. 2010;55:2352-2356.
7. Ogino S, Meyerhardt JA, Kawasaki T, et al. Cpg island methylation, response to combination chemotherapy, and patient survival in advanced microsatellite stable colorectal carcinoma. Virchows Arch. 2007;450:529-537.
8. Ogino S, Nosho K, Kirkner GJ, et al. Cpg island methylator phenotype, microsatellite instability, braf mutation and clinical outcome in colon cancer. Gut. 2009;58:90-96.
9. Samowitz WS, Sweeney C, Herrick J, et al. Poor survival associated with the braf v600e mutation in microsatellite-stable colon cancers. Cancer Res. 2005;65:6063-6069.
10. Ferracin M, Gafa R, Miotto E, et al. The methylator phenotype in microsatellite stable colorectal cancers is characterized by a distinct gene expression profile. J Pathol. 2008;214:594-602.
11. Hawkins N, Norrie M, Cheong K, et al. Cpg island methylation in sporadic colorectal cancers and its relationship to microsatellite instability. Gastroenterology. 2002;122:1376-1387.