Adaptive extensions of a two-stage group sequential procedure for testing primary and secondary endpoints (II): Sample size re-estimation

Statistics in Medicine

Volumn 31, Issue 19, 2012, Pages 2041-2054

  Tamhane, Ajit C ^a   Wu, Yi ^a   Mehta, Cyrus R ^b,c  

^a NORTHWESTERN UNIVERSITY   (United States)

^b Cytel Corporation   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Adaptive designs; Familywise error rate; Gatekeeping procedures; Multiple comparisons; Multiple endpoints; O'Brien Fleming boundary; Pocock boundary; Sample size re estimation

Indexed keywords

ARTICLE; CALCULATION; CORRELATION COEFFICIENT; CUI HUANG WANG STATISTICS; DATA ANALYSIS; FAMILYWISE ERROR RATE; HUMAN; MATHEMATICAL MODEL; SAMPLE SIZE; STATISTICAL ANALYSIS; STATISTICAL CONCEPTS; TWO STAGE GROUP SEQUENTIAL PROCEDURE;

BIAS (EPIDEMIOLOGY); COMPUTER SIMULATION; CONFIDENCE INTERVALS; DATA INTERPRETATION, STATISTICAL; ENDPOINT DETERMINATION; HUMANS; MODELS, STATISTICAL; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RESEARCH DESIGN; SAMPLE SIZE;

EID: 84864025448     PISSN: 02776715     EISSN: 10970258     Source Type: Journal    
DOI: 10.1002/sim.5377     Document Type: Article

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