Faecal short chain fatty acids in healthy subjects participating in a randomised controlled trial examining a soluble highly viscous polysaccharide versus control

Journal of Human Nutrition and Dietetics

Volumn 25, Issue 4, 2012, Pages 373-377

  Reimer, R A ^a   Pelletier, X ^b   Carabin, I G ^c   Lyon, M R ^d,e   Gahler, R J ^f   Wood, S ^d,e  

^a UNIVERSITY OF CALGARY   (Canada)

^b OPTIMED Clinical Research   (France)

^c Burdock Group   (United States)

^d Canadian Centre for Functional Medicine   (Canada)

^e UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^f Factors Group R and D   (Canada)

Author keywords

Acetate; Dietary fibre; Functional fibre; Microbial fermentation; Polysaccharide

Indexed keywords

BACTERIA (MICROORGANISMS);

ACETIC ACID DERIVATIVE; LACTIC ACID; PLACEBO; POLYSACCHARIDE; VOLATILE FATTY ACID;

ADOLESCENT; ADULT; ARTICLE; CHEMISTRY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIETARY FIBER; DOUBLE BLIND PROCEDURE; FECES; FEMALE; FERMENTATION; HUMAN; INTESTINE; MALE; METABOLISM; MICROBIOLOGY; MIDDLE AGED; PH; RANDOMIZED CONTROLLED TRIAL; VISCOSITY;

ACETATES; ADOLESCENT; ADULT; DIETARY FIBER; DOUBLE-BLIND METHOD; FATTY ACIDS, VOLATILE; FECES; FEMALE; FERMENTATION; HUMANS; HYDROGEN-ION CONCENTRATION; INTESTINES; LACTIC ACID; MALE; MIDDLE AGED; PLACEBOS; POLYSACCHARIDES; VISCOSITY;

EID: 84864004001     PISSN: 09523871     EISSN: 1365277X     Source Type: Journal    
DOI: 10.1111/j.1365-277X.2012.01230.x     Document Type: Article

References (17)

1. Brinkworth, G.D., Noakes, M., Clifton, P.M. & Bird, A.R. (2009) Comparative effects of very low-carbohydrate, high-fat and high-carbohydrate, low-fat weight-loss diets on bowel habit and faecal short-chain fatty acids and bacterial populations. Br. J. Nutr. 101, 1493-1502.
2. Carabin, I.G., Lyon, M.R., Wood, S., Pelletier, X., Donazzolo, Y. & Burdock, G.A. (2009) Supplementation of the diet with the functional fiber PolyGlycopleX® is well tolerated by healthy subjects in a clinical trial. Nutr. J. 8, 9.
3. Lyon, M., Wood, S., Pelletier, X., Donazzolo, Y., Gahler, R. & Bellisle, F. (2011) Effects of a 3-month supplementation with a novel soluble highly viscous polysaccharide on anthropometry and blood lipids in nondieting overweight or obese adults. J. Hum. Nutr. Diet. 24, 351-359.
4. Majid, H.A., Emery, P.W. & Whelan, K. (2011) Faecal microbiota and short-chain fatty acids in patients receiving enteral nutrition with standard or fructo-oligosaccharides and fibre-enriched formulas. J. Hum. Nutr. Diet. 24, 260-268.
5. Matulka, R.A., Lyon, M.R., Wood, S., Marone, P.A., Merkel, D.J. & Burdock, G.A. (2009) The safety of PolyGlycopleX® (PGX®) as shown in a 90-day rodent feeding study. Nutr. J. 8, 1.
6. Ramirez-Farias, C., Slezak, K., Fuller, Z., Duncan, A., Holtrop, G. & Louis, P. (2009) Effect of inulin on the human gut microbiota: stimulation of Bifidobacterium adolescentis and Faecalibacterium prausnitzii. Br. J. Nutr. 101, 541-550.
7. Raninen, K., Lappi, J., Mykkanen, H. & Poutanen, K. (2011) Dietary fiber type reflects physiological functionality: comparison of grain fiber, inulin, and polydextrose. Nutr. Rev. 69, 9-21.
8. ® in healthy adults. Eur. J. Clin. Nutr. 64, 1186-1191.
9. Stewart, M.L. & Slavin, J.L. (2009) Particle size and fraction of wheat bran influence short-chain fatty acid production in vitro. Br. J. Nutr. 102, 1404-1407.
10. Stewart, M.L., Nikhani, S.D., Timm, D.A., Thomas, W. & Slavin, J.L. (2010) Evaluation of the effect of four fibers on laxation, gastrointestinal tolerance and serum markers in healthy humans. Ann. Nutr. Metab. 56, 91-98.
11. Topping, D.L. & Clifton, P.M. (2001) Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides. Physiol. Rev. 81, 1031-1064.
12. Torii, T., Kanemitsu, K., Wada, T., Itoh, S., Kinugawa, K. & Hagiwara, A. (2010) Measurement of short-chain fatty acids in human faeces using high-performance liquid chromatography: specimen stability. Ann. Clin. Biochem. 47, 447-452.
13. Van Nuenen, H.M.C., Meyer, P.D. & Venema, K. (2003) The effect of various inulins and Clostridium difficile on the metabolic activity of the human colonic microbiota in vitro. Microb. Ecol. Health Dis. 15, 137-144.
14. Vuksan, V., Rogovik, A.L., Jovanovski, E. & Jenkins, A.L. (2009) Fiber facts: benefits and recommendations for individuals with type 2 diabetes. Curr. Diabetes Reports 9, 405-411.
15. Whelan, K., Judd, P.A., Preedy, V.R., Simmering, R., Jann, A. & Taylor, M.A. (2005) Fructooligosaccharides and fiber partially prevent the alterations in fecal microbiota and short-chain fatty acid concentrations caused by standard enteral formula in healthy humans. J. Nutr. 135, 1896-1902.
16. Wolever, T.M., Schrade, K.B., Vogt, J.A., Tsihlias, E.B. & McBurney, M.I. (2002) Do colonic short-chain fatty acids contribute to the long-term adaptation of blood lipids in subjects with type 2 diabetes consuming a high-fiber diet? Am. J. Clin. Nutr. 75, 1023-1030.
17. Wong, J.M., de Souza, R., Kendall, C.W., Emam, A. & Jenkins, D.J. (2006) Colonic health: fermentation and short chain fatty acids. J. Clin. Gastroenterol. 40, 235-243.