A single amino acid at the hemagglutinin cleavage site contributes to the pathogenicity and neurovirulence of H5N1 influenza virus in mice

Journal of Virology

Volumn 86, Issue 12, 2012, Pages 6924-6931

  Zhang, Yi ^a   Sun, Yipeng ^a   Sun, Honglei ^a   Pu, Juan ^a   Bi, Yuhai ^b   Shi, Yi ^b   Lu, Xishan ^b   Li, Jing ^c   Zhu, Qingyu ^c   Gao, George F ^b   Yang, Hanchun ^a   Liu, Jinhua ^a  

^a CHINA AGRICULTURAL UNIVERSITY   (China)

^b INSTITUTE OF MICROBIOLOGY   (China)

^c BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; GLYCINE; ISOLEUCINE; SERINE; VIRUS HEMAGGLUTININ;

AMINO ACID ANALYSIS; AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHICKEN; CLADISTICS; CONTROLLED STUDY; FEMALE; GENE DELETION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INFLUENZA A (H5N1); MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; REVERSE GENETICS; SPECIES DIFFERENCE; STRUCTURAL BIOINFORMATICS; STRUCTURE ANALYSIS; VIRAL TROPISM; VIRUS RECOMBINANT; VIRUS REPLICATION; VIRUS STRAIN; VIRUS VIRULENCE;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CHICKENS; FEMALE; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HUMANS; INFLUENZA A VIRUS, H5N1 SUBTYPE; INFLUENZA IN BIRDS; INFLUENZA, HUMAN; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; PROTEIN PROCESSING, POST-TRANSLATIONAL; VIRULENCE;

MAMMALIA; MUS; ORTHOMYXOVIRIDAE;

EID: 84864003834     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.07142-11     Document Type: Article

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