An update on plant derived anti-androgens

International Journal of Endocrinology and Metabolism

Volumn 10, Issue 2, 2012, Pages 497-502

  Grant, Paul ^a   Ramasamy, Shamin ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Androgens; Anti androgens; Prostate cancer; Prostatic hyperplasia; Spearmint

Indexed keywords

ANDROSTANOLONE; ANTIANDROGEN; BICALUTAMIDE; CIMICIFUGA RACEMOSA EXTRACT; CYPROTERONE ACETATE; DUTASTERIDE; ESTROGEN; FINASTERIDE; FLUTAMIDE; HERBACEOUS AGENT; KETOCONAZOLE; NILUTAMIDE; PLACEBO; SPIRONOLACTONE; STEROID 5ALPHA REDUCTASE; TAMSULOSIN; VITEX AGNUS CASTUS EXTRACT;

ACNE; ACNE VULGARIS; CIMICIFUGA RACEMOSA; CUSHING SYNDROME; DRUG EFFICACY; DRUG INDICATION; DRUG MECHANISM; DRUG SAFETY; EVIDENCE BASED MEDICINE; GANODERMA LUCIDUM; GLYCYRRHIZA GLABRA; HIRSUTISM; HUMAN; HYPERPROLACTINEMIA; LIVER INJURY; LOW DRUG DOSE; MALE TYPE ALOPECIA; MASTALGIA; MENTHA SPICATA; NOCTURIA; OVARY POLYCYSTIC DISEASE; PAEONIA LACTIFLORA; PREMENSTRUAL SYNDROME; PROSTATE CARCINOMA; PROSTATE HYPERTROPHY; REVIEW; SABAL; SEXUAL DEVIATION; SYSTEMATIC REVIEW; TEA; UNSPECIFIED SIDE EFFECT; VITEX AGNUS CASTUS;

EID: 84864001179     PISSN: 1726913X     EISSN: 17269148     Source Type: Journal    
DOI: 10.5812/ijem.3644     Document Type: Review

References (29)

1. Grant P. Polycystic ovary syndrome. [Available from: http://www. yourhormones.info/endocrine_conditions/polycystic_ovary_ syndrome.aspx.
2. Lee OD. Think androgen deficiency. Am J Mens Health. 2011;5(5):377.
3. Fujita R, Liu J, Shimizu K, Konishi F, Noda K, Kumamoto S, et al. Anti-androgenic activities of Ganoderma lucidum. J Ethnopharmacol. 2005;102(1):107-12.
4. Armanini D, Bonanni G, Palermo M. Reduction of serum testosterone in men by licorice. N Engl J Med. 1999;341(15):1158.
5. Somjen D, Knoll E, Vaya J, Stern N, Tamir S. Estrogen-like activ-ity of licorice root constituents: glabridin and glabrene, in vascular tissues in vitro and in vivo. J Steroid Biochem Mol Biol. 2004;91(3):147-55.
6. Tamir S, Eizenberg M, Somjen D, Izrael S, Vaya J. Estrogen-like activity of glabrene and other constituents isolated from licorice root. J Steroid Biochem Mol Biol. 2001;78(3):291-8.
7. Takeuchi T, Nishii O, Okamura T, Yaginuma T. Effect of paeoniflorin, glycyrrhizin and glycyrrhetic acid on ovarian androgen production. Am J Chin Med. 1991;19(1):73-8.
8. Grant P, Dworakowska D. Tea and Diabetes: the laboratory and the real world. Book chapter in Tea in Health & Disease Prevention. 1st ed. Edited by Preedy V, editor: Elsevier Academic Press; 2012.
9. Akdogan M, Tamer MN, Cure E, Cure MC, Koroglu BK, Delibas N. Effect of spearmint (Mentha spicata Labiatae) teas on androgen levels in women with hirsutism. Phytother Res. 2007;21(5):444-7.
10. Grant P. Spearmint herbal tea has significant anti-androgen effects in polycystic ovarian syndrome. A randomized controlled trial. Phytother Res. 2010;24(2):186-8.
11. Newton KM, Reed SD, LaCroix AZ, Grothaus LC, Ehrlich K, Guiltinan J. Treatment of vasomotor symptoms of menopause with black cohosh, multibotanicals, soy, hormone therapy, or placebo: a randomized trial. Ann Intern Med. 2006;145(12):869-79.
12. Fang ZZ, Nian Y, Li W, Wu JJ, Ge GB, Dong PP, et al. Cycloartane triterpenoids from Cimicifuga yunnanensis induce apoptosis of breast cancer cells (MCF7) via p53-dependent mitochondrial signaling pathway. Phytother Res. 2011;25(1):17-24.
13. Hostanska K, Nisslein T, Freudenstein J, Reichling J, Saller R. Apoptosis of human prostate androgen-dependent and -independent carcinoma cells induced by an isopropanolic extract of black cohosh involves degradation of cytokeratin (CK) 18. Anticancer Res. 2005;25(1A):139-47.
14. Daniele C, Thompson Coon J, Pittler MH, Ernst E. Vitex agnus castus: a systematic review of adverse events. Drug Saf. 2005;28(4):319-32.
15. Webster DE, He Y, Chen SN, Pauli GF, Farnsworth NR, Wang ZJ. Opioidergic mechanisms underlying the actions of Vitex agnuscastus L. Biochem Pharmacol. 2011;81(1):170-7.
16. Azadbakht M, Baheddini A, Shorideh S, Naser Zadeh A. Effect of vitex agnus-castus l. leaf and fruit flavonoidal extracts on serum prolactin concentration. J Med Plants. 2005;4(16):56-61.
17. Merz PG, Gorkow C, Schrodter A, Rietbrock S, Sieder C, Loew D, et al. The effects of a special Agnus castus extract (BP1095E1) on prolactin secretion in healthy male subjects. Exp Clin Endocrinol Diabetes. 1996;104(6):447-53.
18. Grant NN, Anawalt BD. Male hormonal contraception: an update on research progress. Treat Endocrinol. 2002;1(4):217-27.
19. Boyle P, Robertson C, Lowe F, Roehrborn C. Updated metaanalysis of clinical trials of Serenoa repens extract in the treatment of symptomatic benign prostatic hyperplasia. BJU Int. 2004;93(6):751-6.
20. Wilt T, Ishani A, Mac Donald R. Serenoa repens for benign prostatic hyperplasia. Cochrane Database Syst Rev. 2002(3):CD001423.
21. Murugusundram S. Serenoa Repens: Does It have Any Role in the Management of Androgenetic Alopecia? J Cutan Aesthet Surg. 2009;2(1):31-2.
22. Liepa GU, Sengupta A, Karsies D. Polycystic ovary syndrome (PCOS) and other androgen excess-related conditions: can changes in dietary intake make a difference? Nutr Clin Pract. 2008;23(1):63-71.
23. Bent S, Kane C, Shinohara K, Neuhaus J, Hudes ES, Goldberg H, et al. Saw palmetto for benign prostatic hyperplasia. N Engl J Med. 2006;354(6):557-66.
24. Dedhia RC, McVary KT. Phytotherapy for lower urinary tract symptoms secondary to benign prostatic hyperplasia. J Urol. 2008;179(6):2119-25.
25. Geavlete P, Multescu R, Geavlete B. Serenoa repens extract in the treatment of benign prostatic hyperplasia. Ther Adv Urol. 2011;3(4):193-8.
26. Sosnowska J, Balslev H. American palm ethnomedicine: a metaanalysis. J Ethnobiol Ethnomed. 2009;5:43.
27. Tacklind J, MacDonald R, Rutks I, Wilt TJ. Serenoa repens for benign prostatic hyperplasia. Cochrane Database Syst Rev. 2009(2):CD001423.
28. Grant P, Ramasamy S. The Pituitary Gland & Erectile Dysfunction. Book chapter in Erectile Dysfunction: Causes, Risk Factors & Management.: Editor P.Grant. Nova Publishers; 2012.
29. Magin PJ, Adams J, Heading GS, Pond DC, Smith W. Complementary and alternative medicine therapies in acne, psoriasis, and atopic eczema: results of a qualitative study of patients' experiences and perceptions. J Altern Complement Med. 2006;12(5):451-7.