Heterosexual men and women both show a hypothalamic response to the chemo-signal androstadienone

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Burke, Sarah M ^a   Veltman, Dick J ^a   Gerber, Johannes ^b   Hummel, Thomas ^b   Bakker, Julie ^a,c,d  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF DRESDEN MEDICAL SCHOOL   (Germany)

^c UNIVERSITY OF LIÈGE   (Belgium)

^d NETHERLANDS INSTITUTE FOR NEUROSCIENCE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTA 4,16 DIEN 3 ONE;

ADULT; ARTICLE; BRAIN FUNCTION; CONCENTRATION RESPONSE; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HETEROSEXUAL FEMALE; HETEROSEXUAL MALE; HUMAN; HUMAN EXPERIMENT; HYPOTHALAMUS; MALE; NORMAL HUMAN; SEX DIFFERENCE; SMELLING;

ADULT; ANDROSTADIENES; BRAIN MAPPING; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HETEROSEXUALITY; HUMANS; HYPOTHALAMUS; MAGNETIC RESONANCE IMAGING; MALE; ODORS; SEX FACTORS; SMELL; STEROIDS;

EID: 84863995543     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0040993     Document Type: Article

References (42)

1. Wyatt TD, (2009) Fifty years of pheromones. Nature 457: 262-263 doi:10.1038/457262a.
2. Lundström JN, Jones-Gotman M, (2009) Romantic love modulates women's identification of men's body odors. Hormones and Behavior 55: 280-284 doi:10.1016/j.yhbeh.2008.11.009.
3. Lundström JN, Boyle J a, Zatorre RJ, Jones-Gotman M, (2009) The neuronal substrates of human olfactory based kin recognition. Human Brain Mapping 30: 2571-2580 doi:10.1002/hbm.20686.
4. Schaal B, Coureaud G, Doucet S, Aunay-El AM, Moncomble AS, et al. (2009) Mammary olfactory signalisation in females and odor processing in neonates: ways evolved by rabbits and humans. BehavBrain Res 200: 346-358.
5. Gower DB, Holland KT, Mallet AI, Rennie PJ, Watkins WJ, (1994) Comparison of 16-androstene steroid concentrations in sterile apocrine sweat and axillary secretions: interconversions of 16-androstenes by the axillary microflora-a mechanism for axillary odour production in man? The Journal of Steroid Biochemistry and Molecular Biology 48: 409-418.
6. Nixon A, Mallet AI, Gower DB, (1988) Simultaneous quantification of five odorous steroids (16-androstenes) in the axillary hair of men. Journal of Steroid Biochemistry 29: 505-510.
7. Bensafi M, Tsutsui T, Khan R, Levenson RW, Sobel N, (2004) Sniffing a human sex-steroid derived compound affects mood and autonomic arousal in a dose-dependent manner. Psychoneuroendocrinology 29: 1290-1299 doi:10.1016/j.psyneuen.2004.03.007.
8. Lundström JN, Olsson MJ, Schaal B, Hummel T, (2006) A putative social chemosignal elicits faster cortical responses than perceptually similar odorants. NeuroImage 30: 1340-1346 doi:10.1016/j.neuroimage.2005.10.040.
9. Villemure C, Bushnell MC, (2007) The effects of the steroid androstadienone and pleasant odorants on the mood and pain perception of men and women. European Journal of Pain 11: 181-191 doi:10.1016/j.ejpain.2006.02.005.
10. Bensafi M, Brown WM, Khan R, Levenson B, Sobel N, (2004) Sniffing human sex-steroid derived compounds modulates mood, memory and autonomic nervous system function in specific behavioral contexts. Behavioural Brain Research 152: 11-22 doi:10.1016/j.bbr.2003.09.009.
11. Jacob S, Hayreh DJ, McClintock MK, (2001) Context-dependent effects of steroid chemosignals on human physiology and mood. Physiology & Behavior 74: 15-27.
12. Bensafi M, Brown WM, Tsutsui T, Mainland JD, Johnson BN, et al. (2003) Sex-steroid derived compounds induce sex-specific effects on autonomic nervous system function in humans. Behavioral Neuroscience 117: 1125-1134 doi:10.1037/0735-7044.117.6.1125.
13. Jacob S, McClintock MK, (2000) Psychological state and mood effects of steroidal chemosignals in women and men. Hormones and Behavior 37: 57-78 doi:10.1006/hbeh.1999.1559.
14. Wyart C, Webster WW, Chen JH, Wilson SR, McClary A, et al. (2007) Smelling a single component of male sweat alters levels of cortisol in women. The Journal of Neuroscience 27: 1261-1265 doi:10.1523/JNEUROSCI.4430-06.2007.
15. Hummer T, McClintock MK, (2009) Putative human pheromone androstadienone attunes the mind specifically to emotional information. Hormones and behavior 55: 548-559 doi:10.1016/j.yhbeh.2009.01.002.
16. Lundstöm J, (2003) Psychological effects of subthreshold exposure to the putative human pheromone 4,16-androstadien-3-one. Hormones and Behavior 44: 395-401 doi:10.1016/j.yhbeh.2003.06.004.
17. Lundström JN, (2003) Individual Differences in Sensitivity to the Odor of 4,16-Androstadien-3-one. Chemical Senses 28: 643-650 doi:10.1093/chemse/bjg057.
18. Berglund H, Lindström P, Savic I, (2006) Brain response to putative pheromones in lesbian women. Proc Natl Acad of Sci 103: 8269-8274.
19. Savic I, Berglund H, Lindström P, (2005) Brain response to putative pheromones in homosexual men. Proc Natl Acad of Sci 102: 7356-7361.
20. Savic I, Berglund H, Gulyas B, Roland P, (2001) Smelling of odorous sex hormone-like compounds causes sex-differentiated hypothalamic activations in humans. Neuron 31: 661-668.
21. Savic I, Gulyas B, Hatt H, Berglund H, (2000) Male pheromone activates anterior hypothalamus in female subjects. NeuroImage 11: s751.
22. Kobal G, Klimek L, Wolfensberger M, Gudziol H, Temmel A, et al. (2000) Multicenter investigation of 1,036 subjects using a standardized method for the assessment of olfactory function combining tests of odor identification, odor discrimination, and olfactory thresholds. European Archives of Oto-rhino-laryngology 257: 205-211.
23. Sommer JU, Heiser C, Griebe M, Stuck BA, Hummel T, (2011) Riech-O-Mat: A small and simple olfactometer for fMRI studies. Abstract at the Annual Conference of the Association for Chemoreception Sciences (AChemS). Available:http://www.achems.org/files/2011 Meeting Files/FINALABSTRACTS.pdf.
24. Brett M, Anton J, Valabregue R, Poline J-B, (2002) Region of interest analysis using an SPM toolbox. Presented at the 8th International Conference on Functional Mapping of the Human Brain. Sendai, Japan. Available: on CD-ROM in NeuroImage; Vol 16; No 2 http://marsbar.sourceforge.net/.
25. Brunetti M, Babiloni C, Ferretti A, Del Gratta C, Merla A, et al. (2008) Hypothalamus, sexual arousal and psychosexual identity in human males: a functional magnetic resonance imaging study. The European Journal of Neuroscience 27: 2922-2927 doi:10.1111/j.1460-9568.2008.06241.x.
26. Savic I, Berglund H, (2010) Androstenol - a Steroid Derived Odor Activates the Hypothalamus in Women. PLoS ONE 5: e8651 doi:10.1371/journal.pone.0008651.
27. Savic I, (2002) Imaging of brain activation by odorants in humans. Current Opinion in Neurobiology 12: 455-461 doi:10.1016/S0959-4388(02)00346-X.
28. Savic I, Hedén-Blomqvist E, Berglund H, (2009) Pheromone signal transduction in humans: what can be learned from olfactory loss. Human Brain Mappingapping 30: 3057-3065 doi:10.1002/hbm.20727.
29. Goldstein JM, Jerram M, Abbs B, Whitfield-Gabrieli S, Makris N, (2010) Sex differences in stress response circuitry activation dependent on female hormonal cycle. The Journal of Neuroscience 30: 431-438 doi:10.1523/JNEUROSCI.3021-09.2010.
30. Jacob S, Kinnunen LH, Metz J, Cooper M, McClintock MK, (2001) Sustained human chemosignal unconsciously alters brain function. Neuroreport 12: 2391-2394.
31. Maldjian JA, Laurienti PJ, Kraft RA, Burdette JH, (2003) An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Neuroimage 19: 1233-1239.
32. Preti G, Wysocki CJ, Barnhart KT, Sondheimer SJ, Leyden JJ, (2003) Male axillary extracts contain pheromones that affect pulsatile secretion of luteinizing hormone and mood in women recipients. Biology of Reproduction 68: 2107-2113 doi:10.1095/biolreprod.102.008268.
33. Ferdenzi C, Schaal B, Roberts SC, (2009) Human axillary odor: are there side-related perceptual differences? ChemSenses 34: 565-571.
34. Doty RL, Orndorff MM, Leyden J, Kligman A, (1978) Communication of gender from human axillary odors: relationship to perceived intensity and hedonicity. Behavioral Biology 23: 373-380.
35. Hummel T, Gollisch R, Wildt G, Kobal G, (1991) Changes in olfactory perception during the menstrual cycle. Experientia 47: 712-715.
36. Sewards TV, Sewards M a, (2003) Representations of motivational drives in mesial cortex, medial thalamus, hypothalamus and midbrain. Brain Research Bulletin 61: 25-49 doi:10.1016/S0361-9230(03)00069-8.
37. Kang N, McCarthy E, Cherry J, Baum MJ, (2011) A sex comparison of the anatomy and function of the main olfactory bulb-medial amygdala projection in mice. Neuroscience 172: 196-204 doi:10.1016/j.neuroscience.2010.11.003.
38. Grabenhorst F, Rolls ET, Parris BA, D'Souza AA, (2010) How the Brain Represents the Reward Value of Fat in the Mouth. CerebCortex 20: 1082-1091 doi:10.1093/cercor/bhp169.
39. Lundström J, (2003) Psychological effects of subthreshold exposure to the putative human pheromone 4,16-androstadien-3-one. Hormones and Behavior 44: 395-401 doi:10.1016/j.yhbeh.2003.06.004.
40. Lundström JN, Boyle JA, Jones-Gotman M, (2006) Sit up and smell the roses better: olfactory sensitivity to phenyl ethyl alcohol is dependent on body position. ChemSenses 31: 249-252.
41. Lundström JN, Boyle JA, Jones-Gotman M, (2008) Body position-dependent shift in odor percept present only for perithreshold odors. ChemSenses 33: 23-33.
42. Mester AF, Doty RL, Shapiro A, Frye RE, (1988) Influence of body tilt within the sagittal plane on odor identification performance. Aviation, space, and environmental medicine 59: 734-737.