Bioactivity guided isolation of antipsychotic constituents from the leaves of Rauwolfia tetraphylla L.

Fitoterapia

Volumn 83, Issue 6, 2012, Pages 1092-1099

  Gupta, Shikha ^a   Khanna, Vinay Kumar ^b   Maurya, Anupam ^a   Bawankule, Dnyaneshwar Umrao ^a   Shukla, Rajendra Kumar ^b   Pal, Anirban ^a   Srivastava, Santosh Kumar ^a  

^a CSIR CENTRAL INSTITUTE OF MEDICINAL AND AROMATIC PLANTS   (India)

^b CSIR INDIAN INSTITUTE OF TOXICOLOGY RESEARCH   (India)

Author keywords

Amphetamine induced hyperactive mouse model; Antipsychotic alkaloids; Dopaminergic (DA D2) receptor; Rauwolfia tetraphylla; Serotonergic (5 HT2A) receptor

Indexed keywords

10 DEMETHOXYRESERPILINE; 10 METHOXYTETRAHYDROALSTONINE; 11 DEMETHOXYRESERPILINE; ALKALOID DERIVATIVE; DOPAMINE 2 RECEPTOR; ISORESERPILINE; NEUROLEPTIC AGENT; RAUWOLFIA ALKALOID; RAUWOLFIA TETRAPHYLLA EXTRACT; RAUWOLSCINE; RESERPILINE; SEROTONIN 2A RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOCHEMICAL COMPOSITION; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG ISOLATION; DRUG SAFETY; DRUG STRUCTURE; FEMALE; HYPERACTIVITY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PLANT LEAF; PRIORITY JOURNAL; RAUWOLFIA; RECEPTOR OCCUPANCY;

AMPHETAMINE; ANIMALS; ANTIPSYCHOTIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HYDROGEN-ION CONCENTRATION; HYPERKINESIS; INDOLE ALKALOIDS; MICE; MICE, INBRED STRAINS; NEUROTRANSMITTER AGENTS; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; RAUWOLFIA; RECEPTORS, BIOGENIC AMINE; RECEPTORS, DOPAMINE; RECEPTORS, SEROTONIN;

MUS; RAUVOLFIA TETRAPHYLLA;

EID: 84863985980     PISSN: 0367326X     EISSN: 18736971     Source Type: Journal    
DOI: 10.1016/j.fitote.2012.04.029     Document Type: Article

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