Prenatal testosterone influence on reelin expression in association with autism

Activitas Nervosa Superior Rediviva

Volumn 52, Issue 4, 2010, Pages 247-252

  Lakatošová, Silvia ^a   Schmidtová, Eva ^a   Celec, Peter ^a,b   Janega, Pavol ^a,c   Kubranská, Aneta ^a   Durdiaková, Jaroslava ^a   Ostatníková, Daniela ^a  

^a Bratislava   (Slovakia)

^b Faculty of Natural Sciences   (Slovakia)

^c INSTITUTE OF CHEMISTRY   (Slovakia)

Author keywords

Autism; Candidate gene; Reelin; Spatial abilities; Testosterone

Indexed keywords

REELIN; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTISM; CEREBELLUM; CONTROLLED STUDY; DISEASE MODEL; FEMALE; GENE CONTROL; GENE EXPRESSION; GENETIC ASSOCIATION; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; MALE; NEWBORN; NONHUMAN; PARIETAL CORTEX; PATHOGENESIS; PREGNANCY; PRENATAL DEVELOPMENT; PROGENY; RAT; REAL TIME POLYMERASE CHAIN REACTION; STARLING;

EID: 84863985294     PISSN: 1337933X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Absil P, Pinxten R, Balthazart J, Eens M (2003). Effects of testosterone on Reelin expression in the brain of male European starlings. Cell Tissue Res. 312: 81-93.
2. Andres C (2002). Molecular genetics and animal models in autistic disorder. Brain Res Bull. 57: 109-119.
3. Auyeung B, Baron-Cohen S, Ashwin E, Knickmeyer R, Taylor K, Hackett G (2009). Fetal testosterone and autistic traits. Br J Psychol. 100: 1-22.
4. Ball GF, Castelino CB, Maney DL, Appeltants D, Balthazart J (2003). The activation of birdsong by testosterone: multiple sites of action and role of ascending catecholamine projections. Ann N Y Acad Sci. 1007: 211-231.
5. Baron-Cohen S, Knickmeyer RC, Belmonte MK (2005). Sex differences in the brain: implications for explaining autism. Science. 310: 819-823.
6. Celec P & Ostatnikova D (2010). Autism and Genome-Wide Association Studies. Act Nerv Super Rediviva. 52: 28-30.
7. Chapman E, Baron-Cohen S, Auyeung B, Knickmeyer R, Taylor K, Hackett G (2006). Fetal testosterone and empathy: evidence from the empathy quotient (EQ) and the "reading the mind in the eyes" test. Soc Neurosci. 1: 135-148.
8. D'Arcangelo G, Miao GG, Chen SC, Soares HD, Morgan JI, Curran T (1995). A protein related to extracellular matrix proteins deleted in the mouse mutant reeler. Nature. 374: 719-723.
9. Fatemi SH, Stary JM, Egan EA (2002). Reduced blood levels of reelin as a vulnerability factor in pathophysiology of autistic disorder. Cell Mol Neurobiol. 22: 139-152.
10. Fatemi SH, Snow AV, Stary JM, Araghi-Niknam M, Reutiman TJ, Lee S et al (2005). Reelin signaling is impaired in autism. Biol Psychiatry. 57: 777-787.
11. Folstein SE & Rosen-Sheidley B (2002). Genetics of autism: complex aetiology for a heterogeneous disorder. Nat Rev Genet. 2: 943-955.
12. Krajmer P, Janosikova D, Spajdel M, Ostatnikova D (2010). Empathizing, systemizing, intuitive physics and folk psychology in boys with Asperger syndrome. Act Nerv Super Rediviva. 52: 57-61.
13. Knickmeyer R, Baron-Cohen S, Raggat P, Taylor K (2005). Foetal testosterone, social relationships, and restricted interests in children. J Child Psychol Psychiatry. 46: 198-210.
14. Knickmeyer R, Baron-Cohen S, Fane BA, Wheelwright S, Mathews GA, Conway GS et al (2006). Androgens and autistic traits: A study of individuals with congenital adrnal hyperplasia. Horm Behav. 50: 148-153.
15. Persico AM, D'Agruma L, Maiorano N, Totaro A, Militerni R, Bravaccio C et al (2001). Reelin gene alleles and haplotypes as a factor predisposing to autistic disorder. Mol Psychiatry. 6: 129-133.
16. Persico AM & Bourgeron T (2006). Searching for ways out of the autism maze: genetic, epigenetic and environmental clues. Trends Neurosci. 29: 349-358.
17. Persico AM, Levitt P, Pimenta AF (2006). Polymorphic GGC repeat differentially regulates human reelin gene expression levels. J Neural Transm. 113: 1373-1382.
18. The autism genome project consortium (2007). Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nat Genet. 39: 319-328.
19. Veenstra-VanderWeele J & Cook EH, Jr. (2004). Molecular genetics of autism spectrum disorder. Mol Psychiatry. 9: 819-832.