Ascorbic acid deficiency leads to epidermal atrophy and UVB-induced skin pigmentation in SMP30/GNL knockout hairless mice

Journal of Investigative Dermatology

Volumn 132, Issue 8, 2012, Pages 2112-2115

  Sato, Yasunori ^a,c   Arai, Koji Y ^b   Nishiyama, Toshio ^b   Nomura, Yoshihiro ^b   Kishimoto, Yuki ^a   Aizawa, Shingo ^a   Maruyama, Naoki ^a   Ishigami, Akihito ^a  

^a TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^b TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

^c OHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; COLLAGEN TYPE 4; CYTOKERATIN 14; FILAGGRIN; GLUCONOLACTONASE; INVOLUCRIN; LORICRIN; REGUCALCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ASCORBIC ACID DEFICIENCY; CELL DIFFERENTIATION; CELL PROLIFERATION; CUTANEOUS PARAMETERS; EPIDERMIS ATROPHY; GENE INACTIVATION; HISTOLOGY; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; KNOCKOUT MOUSE; LETTER; MELANOCYTE; MELANOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SKIN ATROPHY; SKIN COLOR; SKIN PIGMENTATION; SKINFOLD THICKNESS; ULTRAVIOLET B RADIATION;

EID: 84863985286     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2012.105     Document Type: Letter

References (8)

1. Bhattacharyya TK, Thomas JR (2004) Histomorphologic changes in aging skin: observations in the CBA mouse model. Arch Facial Plast Surg 6:21-5
2. Bielski BH, Richter HW, Chan PC (1975) Some properties of the ascorbate free radical. Ann NY Acad Sci 258:231-7
3. Iwama M, Shimokado K, Maruyama N et al. (2011) Time course of vitamin C distribution and absorption after oral administration in SMP30/GNL knockout mice. Nutrition 27:471-8
4. Kondo Y, Inai Y, Sato Y et al. (2006) Senescence marker protein 30 functions as gluconolactonase in L-ascorbic acid biosynthesis, and its knockout mice are prone to scurvy. Proc Natl Acad Sci USA 103:5723-8
5. Nishikimi M (1975) Oxidation of ascorbic acid with superoxide anion generated by the xanthine-xanthine oxidase system. Biochem Biophys Res Commun 63:463-8
6. Peterkofsky B, Udenfriend S (1965) Enzymatic hydroxylation of proline in microsomal polypeptide leading to formation of collagen. Proc Natl Acad Sci USA 53:335-42
7. Seike M, Ikeda M, Morimoto A et al. (2002) Increased synthesis of calcitonin gene-related peptide stimulates keratinocyte proliferation in murine UVB-irradiated skin. J Dermatol Sci 28:135-43
8. Stewart MS, Cameron GS, Pence BC (1996) Antioxidant nutrients protect against UVBinduced oxidative damage to DNA of mouse keratinocytes in culture. J Invest Dermatol 106:1086-9