Clinical experience with oral lacosamide as adjunctive therapy in adult patients with uncontrolled epilepsy: A multicentre study in epilepsy clinics in the United Kingdom (UK)

Seizure

Volumn 21, Issue 7, 2012, Pages 512-517

  Flores, Lorena ^a   Kemp, Steven ^b   Colbeck, Katie ^b   Moran, Nicholas ^a,c   Quirk, Jennifer ^d   Ramkolea, Pierre ^e   Von Oertzen, Tim J ^f   Nashef, Lina ^a   Richardson, Mark P ^a,h   Goulding, Peter ^g   Elwes, Robert ^a  

^a KING'S COLLEGE HOSPITAL NHS FOUNDATION TRUST   (United Kingdom)

^b ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

^c KENT AND CANTERBURY HOSPITAL   (United Kingdom)

^d Princess Royal University Hospital   (United Kingdom)

^e CHARING CROSS HOSPITAL   (United Kingdom)

^f ST GEORGE S HOSPITAL   (United Kingdom)

^g LEEDS GENERAL INFIRMARY   (United Kingdom)

^h KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Antiepileptic drug; Epilepsy; Lacosamide; Responder rate; Sodium channel blockers

Indexed keywords

CARBAMAZEPINE; CLOBAZAM; ETIRACETAM; HARKOSERIDE; LAMOTRIGINE; OXCARBAZEPINE; PHENOBARBITAL; PHENYTOIN; PRIMIDONE; TIAGABINE; TOPIRAMATE; VALPROIC ACID; ZONISAMIDE;

ADD ON THERAPY; ADOLESCENT; ADULT; AGED; AGGRESSION; APPETITE DISORDER; ARTHRALGIA; ARTICLE; BEHAVIOR DISORDER; BLURRED VISION; COGNITIVE DEFECT; COMPLEX PARTIAL SEIZURE; CONFUSION; DEPERSONALIZATION; DIPLOPIA; DISEASE CONTROL; DIZZINESS; DRUG EFFICACY; DRUG INDUCED HEADACHE; DRUG TOLERABILITY; DRUG WITHDRAWAL; DYSPNEA; EPILEPSY; FEMALE; FOCAL EPILEPSY; FOLLOW UP; GASTROINTESTINAL SYMPTOM; HALLUCINATION; HAND PARESTHESIA; HUMAN; HYPERSALIVATION; IDIOPATHIC GENERALIZED EPILEPSY; LEARNING DISORDER; LEG EDEMA; LIMB PAIN; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; MEMORY DISORDER; MOOD CHANGE; MULTICENTER STUDY; MUSCLE SPASM; MYOCLONUS; NAUSEA; PATIENT COMPLIANCE; PRIORITY JOURNAL; SEDATION; SEIZURE; SIDE EFFECT; SIMPLE PARTIAL SEIZURE; SKIN IRRITATION; SLEEP DISORDER; SLURRED SPEECH; SOMNOLENCE; THOUGHT DISORDER; TONIC CLONIC SEIZURE; TREMOR; UNITED KINGDOM; UNSTEADINESS; WEAKNESS; WEIGHT GAIN;

ACETAMIDES; ADMINISTRATION, ORAL; ADULT; ANTICONVULSANTS; DRUG THERAPY, COMBINATION; EPILEPSY; FEMALE; HUMANS; MALE; RETROSPECTIVE STUDIES;

EID: 84863983862     PISSN: 10591311     EISSN: 15322688     Source Type: Journal    
DOI: 10.1016/j.seizure.2012.05.005     Document Type: Article

References (20)

1. B.K. Beyreuther, J. Freitag, C. Heers, N. Krebsfänger, U. Scharfenecker, and T. Stöhr Lacosamide: a review of preclinical properties CNS drug reviews 13 1 2007 21 42 Available at: http://www.ncbi.nlm.nih.gov/ pubmed/17461888 (Pubitemid 46697839)
2. A. Shaibani, S. Fares, J.L. Selam, A. Arslanian, J. Simpson, and D.B.S. Sen Lacosamide in painful diabetic neuropathy: an 18-week double-blind placebo-controlled trial Journal of Pain 10 2009 818 828
3. P. Halász, R. Kälviäinen, M. Mazurkiewicz- Beldzińska, F. Rosenow, P. Doty, D. Hebert SP755 Study Group Adjunctive lacosamide for partial-onset seizures: Efficacy and safety results from a randomized controlled trial Epilepsia 50 3 2009 443 453 Available at: http://www.ncbi.nlm.nih.gov/pubmed/19183227 [accessed 16.11.11]
4. E. Ben-Menachem, V. Biton, D. Jatuzis, B. Abou-Khalil, P. Doty, and G.D. Rudd Efficacy and safety of oral lacosamide as adjunctive therapy in adults with partial-onset seizures Epilepsia 48 7 2007 1308 1317 Available at: http://www.ncbi.nlm.nih.gov/pubmed/17635557 [accessed 10.06.11] (Pubitemid 47063096)
5. S. Chung, M.R. Sperling, V. Biton, D. Hebert, G.D. Rudd SP754 Study Group Lacosamide as adjunctive therapy for partial-onset seizures: a randomized controlled trial Epilepsia 51 6 2010 958 967 Available at: http://www.ncbi.nlm. nih.gov/pubmed/20132285 [accessed 07.12.11]
6. T. Wehner, S. Bauer, H.M. Hamer, K. Hattemer, I. Immisch, and S. Knake Six months of postmarketing experience with adjunctive lacosamide in patients with pharmacoresistant focal epilepsy at a tertiary epilepsy center in Germany Epilepsy & Behavior 16 3 2009 423 425 Available at: http://www.ncbi.nlm.nih. gov/pubmed/19767242 [accessed 07.12.11]
7. I. García-Morales, R.T. Delgado, M. Falip, D. Campos, M.E. García, and A. Gil-Nagel Early clinical experience with lacosamide as adjunctive therapy in patients with refractory focal epilepsy and nocturnal seizures Seizure: The Journal of the British Epilepsy Association 20 10 2011 801 804 Available at: http://www.ncbi.nlm.nih.gov/pubmed/21917484 [accessed 07.12.11]
8. L.J. Stephen, K. Kelly, P. Parker, and M.J. Brodie Adjunctive lacosamide in clinical practice: Sodium blockade with a difference? Epilepsy & Behavior 22 3 2011 499 504 Available at: http://www.ncbi.nlm.nih.gov/pubmed/21890421 [accessed 07.12.11]
9. C.L. Harden, A. Cohn, M. Lowe, and E. Serrano Initial post marketing experience with lacosamide in adult patients with epilepsy Epilepsy research 98 2-3 2012 260 263 Available at: http://www.ncbi.nlm.nih.gov/pubmed/22015002 [accessed 07.12.11]
10. S.D. Lhatoo, I.C. Wong, G. Polizzi, and J.W. Sander Long-term retention rates of lamotrigine, gabapentin, and topiramate in chronic epilepsy Epilepsia 41 December (12) 2000 1592 1596 (Pubitemid 32002733)
11. H.P. Bootsma, L. Ricker, Y.A. Hekster, J. Hulsman, D. Lambrechts, and M. Majoie The impact of side effects on long-term retention in three new antiepileptic drugs Seizure: The Journal of the British Epilepsy Association 18 5 2009 327 331 Available at: http://www.ncbi.nlm.nih.gov/pubmed/19110447 [accessed 10.12.11]
12. S. Chung, N. Wang, and N. Hank Comparative retention rates and long-term tolerability of new antiepileptic drugs Seizure: The Journal of the British Epilepsy Association 16 4 2007 296 304 Available at: http://www.ncbi.nlm.nih. gov/pubmed/17267243 [accessed 10.12.11] (Pubitemid 46614649)
13. S. Simoens Lacosamide as adjunctive therapy for partial-onset epileptic seizures: a review of the clinical and economic literature Current Medical Research and Opinion 27 7 2011 1329 1338
14. J. Novy, P.N. Patsalos, J.W. Sander, and S.M. Sisodiya Lacosamide neurotoxicity associated with concomitant use of sodium channel-blocking antiepileptic drugs: a pharmacodynamic interaction? Epilepsy & Behavior 20 1 2011 20 23 Available at: http://www.ncbi.nlm.nih.gov/pubmed/21056937 [accessed 07.12.11]
15. F.M. Besag, D.J. Berry, F. Pool, and J.E.S.B. Newbery Carbamazepine toxicity with lamotrigine: pharmacokinetic or pharmacodynamic interaction? Epilepsia 39 2 1998 183 187 (Pubitemid 28074354)
16. M.J.Y.A. Brodie Lamotrigine substitution study: evidence for synergism with sodium valproate? 105 Study Group Epilepsia 26 3 1997 423 432
17. G. Barcs, E.B. Walker, C.E. Elger, A. Scaramelli, H. Stefan, and Y. Sturm Oxcarbazepine placebo-controlled, dose-ranging trial in refractory partial epilepsy Epilepsia 41 12 2000 1597 1607 (Pubitemid 32002734)
18. J.K. Sake, D. Hebert, J. Isojärvi, P. Doty, M. De Backer, and K. Davies A pooled analysis of lacosamide clinical trial data grouped by mechanism of action of concomitant antiepileptic drugs CNS drugs 24 12 2010 1055 1068 Available at: http://www.ncbi.nlm.nih.gov/pubmed/21090839
19. R.J. Simister, J.W. Sander, and M.J. Koepp Long-term retention rates of new antiepileptic drugs in adults with chronic epilepsy and learning disability Epilepsy & behavior: E&B 10 2 2007 336 339 Available at: http://www.ncbi.nlm.nih.gov/pubmed/17267290 [accessed 10.12.11] (Pubitemid 46432229)
20. J. Beavis, and M.M.A. Kerr Pharmacological interventions for epilepsy in people with intellectual disabilities Cochrane Database Systemic Review 18 3 2007 CD0