Measurement of pulsatile total blood flow in the human and rat retina with ultrahigh speed spectral/Fourier domain OCT

Biomedical Optics Express

Volumn 3, Issue 5, 2012, Pages 1047-1061

  Choi, Woo Jhon ^a   Baumann, Bernhard ^a,b   Liu, Jonathan J ^a   Clermont, Allen C ^c   Feener, Edward P ^c   Duker, Jay S ^b   Fujimoto, James G ^a  

^a USA   (United States)

^b TUFTS UNIVERSITY   (United States)

^c JOSLIN DIABETES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DATA PROCESSING; FLOW MEASUREMENT; OPHTHALMOLOGY;

ACQUISITION RATES; ARTERIAL BLOOD; AXIAL VELOCITY; BLOOD FLOW; BLOOD FLOW MEASUREMENT; BLOOD VELOCITY; DOPPLER; DOPPLER OCT; FLOW CALCULATIONS; FLOW CHARACTERISTIC; HUMAN PATIENTS; OCULAR DISEASE; PHASE WRAPPING; RASTER SCANNING; ROBUST ALGORITHM; SCAN AREA; SCAN RATES; SMALL ANIMAL MODEL; SMALL AREA; SPECTRAL DOMAIN OCT; ULTRA HIGH SPEED;

HEMODYNAMICS;

ANIMALIA; RATTUS;

EID: 84863978715     PISSN: None     EISSN: 21567085     Source Type: Journal    
DOI: 10.1364/BOE.3.001047     Document Type: Article

References (28)

1. J. Flammer, S. Orgül, V. P. Costa, N. Orzalesi, G. K. Krieglstein, L. M. Serra, J. P. Renard, and E. Stefánsson. "The impact of ocular blood flow in glaucoma," Prog. Retin. Eye Res. 21(4), 359-393 (2002).
2. R. N. Weinreb and A. Harris, Consensus Series-6: Ocular Blood Flow in Glaucoma (Kugler, Amsterdam, 2009).
3. H. S. Chung, A. Harris, T. A. Ciulla, and L. Kagemann. "Progress in measurement of ocular blood flow and relevance to our understanding of glaucoma and age-related macular degeneration," Prog. Retin. Eye Res. 18(5), 669-687 (1999).
4. E. Friedman. "A hemodynamic model of the pathogenesis of age-related macular degeneration," Am. J. Ophthalmol. 124(5), 677-682 (1997).
5. L. Schmetterer and M. Wolzt. "Ocular blood flow and associated functional deviations in diabetic retinopathy," Diabetologia 42(4), 387-405 (1999).
6. V. Patel, S. Rassam, R. Newsom, J. Wiek, and E. Kohner. "Retinal blood flow in diabetic retinopathy," BMJ 305(6855), 678-683 (1992).
7. Y. M. Wang, B. A. Bower, J. A. Izatt, O. Tan, and D. Huang. "In vivo total retinal blood flow measurement by Fourier domain Doppler optical coherence tomography," J. Biomed. Opt. 12(4), 041215 (2007).
8. R. A. Leitgeb, L. Schmetterer, W. Drexler, A. F. Fercher, R. J. Zawadzki, and T. Bajraszewski. "Real-time assessment of retinal blood flow with ultrafast acquisition by color Doppler Fourier domain optical coherence tomography," Opt. Express 11(23), 3116-3121 (2003).
9. W. Drexler and J. G. Fujimoto, Optical Coherence Tomography: Technology and Applications (Springer-Verlag Berlin, 2008).
10. B. R. White, M. C. Pierce, N. Nassif, B. Cense, B. H. Park, G. J. Tearney, B. E. Bouma, T. C. Chen, and J. F. de Boer. "In vivo dynamic human retinal blood flow imaging using ultra-high-speed spectral domain optical coherence tomography," Opt. Express 11(25), 3490-3497 (2003).
11. R. A. Leitgeb, L. Schmetterer, C. K. Hitzenberger, A. F. Fercher, F. Berisha, M. Wojtkowski, and T. Bajraszewski. "Real-time measurement of in vitro flow by Fourier-domain color Doppler optical coherence tomography," Opt. Lett. 29(2), 171-173 (2004).
12. H. Wehbe, M. Ruggeri, S. Jiao, G. Gregori, C. A. Puliafito, and W. Zhao. "Automatic retinal blood flow calculation using spectral domain optical coherence tomography," Opt. Express 15(23), 15193-15206 (2007).
13. S. Makita, T. Fabritius, and Y. Yasuno. "Quantitative retinal-blood flow measurement with three-dimensional vessel geometry determination using ultrahigh-resolution Doppler optical coherence angiography," Opt. Lett. 33(8), 836-838 (2008).
14. Y. K. Tao, K. M. Kennedy, and J. A. Izatt. "Velocity-resolved 3D retinal microvessel imaging using single-pass flow imaging spectral domain optical coherence tomography," Opt. Express 17(5), 4177-4188 (2009).
15. Y. Wang, A. Lu, J. Gil-Flamer, O. Tan, J. A. Izatt, and D. Huang. "Measurement of total blood flow in the normal human retina using Doppler Fourier-domain optical coherence tomography," Br. J. Ophthalmol. 93(5), 634-637 (2009).
16. R. M. Werkmeister, N. Dragostinoff, M. Pircher, E. Götzinger, C. K. Hitzenberger, R. A. Leitgeb, and L. Schmetterer. "Bidirectional Doppler Fourier-domain optical coherence tomography for measurement of absolute flow velocities in human retinal vessels," Opt. Lett. 33(24), 2967-2969 (2008).
17. Z. Zhi, W. Cepurna, E. Johnson, T. Shen, J. Morrison, and R. K. Wang. "Volumetric and quantitative imaging of retinal blood flow in rats with optical microangiography," Biomed. Opt. Express 2(3), 579-591 (2011).
18. A. S. G. Singh, C. K. Kolbitsch, T. Schmoll, and R. A. Leitgeb. "Stable absolute flow estimation with Doppler OCT based on virtual circumpapillary scans," Biomed. Opt. Express 1(4), 1047-1058 (2010).
19. Y. M. Wang, A. A. Fawzi, R. Varma, A. A. Sadun, X. B. Zhang, O. Tan, J. A. Izatt, and D. Huang. "Pilot study of optical coherence tomography measurement of retinal blood flow in retinal and optic nerve diseases," Invest. Ophthalmol. Vis. Sci. 52(2), 840-845 (2011).
20. V. J. Srinivasan, S. Sakadzić, I. Gorczynska, S. Ruvinskaya, W. C. Wu, J. G. Fujimoto, and D. A. Boas. "Quantitative cerebral blood flow with optical coherence tomography," Opt. Express 18(3), 2477-2494 (2010).
21. M. W. Jenkins, L. Peterson, S. Gu, M. Gargesha, D. L. Wilson, M. Watanabe, and A. M. Rollins. "Measuring hemodynamics in the developing heart tube with four-dimensional gated Doppler optical coherence tomography," J. Biomed. Opt. 15(6), 066022 (2010).
22. B. Baumann, B. Potsaid, M. F. Kraus, J. J. Liu, D. Huang, J. Hornegger, A. E. Cable, J. S. Duker, and J. G. Fujimoto. "Total retinal blood flow measurement with ultrahigh speed swept source/Fourier domain OCT," Biomed. Opt. Express 2(6), 1539-1552 (2011).
23. H. C. Hendargo, R. P. McNabb, A.-H. Dhalla, N. Shepherd, and J. A. Izatt. "Doppler velocity detection limitations in spectrometer-based versus swept-source optical coherence tomography," Biomed. Opt. Express 2(8), 2175-2188 (2011).
24. B. J. Vakoc, S. H. Yun, J. F. de Boer, G. J. Tearney, and B. E. Bouma. "Phase-resolved optical frequency domain imaging," Opt. Express 13(14), 5483-5493 (2005).
25. B. Rao, L. F. Yu, H. K. Chiang, L. C. Zacharias, R. M. Kurtz, B. D. Kuppermann, and Z. P. Chen. "Imaging pulsatile retinal blood flow in human eye," J. Biomed. Opt. 13(4), 040505 (2008).
26. S. Makita, T. Fabritius, and Y. Yasuno. "Full-range, high-speed, high-resolution 1 microm spectral-domain optical coherence tomography using BM-scan for volumetric imaging of the human posterior eye," Opt. Express 16(12), 8406-8420 (2008).
27. A. V. Oppenheim and R. W. Schafer, Discrete-Time Signal Processing (Prentice Hall, 2010).
28. J. Enfield, E. Jonathan, and M. Leahy. "In vivo imaging of the microcirculation of the volar forearm using correlation mapping optical coherence tomography (cmOCT)," Biomed. Opt. Express 2(5), 1184-1193 (2011).