Adipokine expression in brown and white adipocytes in response to hypoxia

Journal of Endocrinological Investigation

Volumn 35, Issue 5, 2012, Pages 522-527

  Wree, A ^a,b   Mayer, A ^c   Westphal, S ^b   Beilfuss, A ^a   Canbay, A ^a   Schick, R R ^b   Gerken, G ^a   Vaupel, P ^c  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

^b BUNDESWEHRKRANKENHAUS ULM   (Germany)

^c UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

Adipokine; Adipose tissue hypoxia; Brown adipose tissue; Hypoxia inducible factor 1

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; ANGIOTENSIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LEPTIN; OXYGEN; UNCOUPLING PROTEIN 1; VASCULOTROPIN;

ANIMAL CELL; ARTICLE; BROWN ADIPOSE TISSUE; CELL ADHESION; CELL HYPOXIA; CELL STRUCTURE; CONTROLLED STUDY; CYTOPLASM; LIPID STORAGE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; WESTERN BLOTTING; WHITE ADIPOSE TISSUE;

ADIPOCYTES, WHITE; ADIPOKINES; ADIPOSE TISSUE, BROWN; ANIMALS; ANOXIA; ANTIMUTAGENIC AGENTS; CELLS, CULTURED; COBALT; DEFEROXAMINE; IMMUNOBLOTTING; LEPTIN; MICE; SIDEROPHORES;

EID: 84863968898     PISSN: 03914097     EISSN: 17208386     Source Type: Journal    
DOI: 10.3275/7964     Document Type: Article

References (45)

1. Klein J, Perwitz N, Kraus D, Fasshauer M. Adipose tissue as source and target for novel therapies. Trends Endocrinol Metab 2006, 17: 26-32. (Pubitemid 43031381)
2. Timmons JA, Wennmalm K, Larsson O, et al. Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages. Proc Natl Acad Sci U S A 2007, 104: 4401-6. (Pubitemid 47186238)
3. Lafontan M. Fat cells: afferent and efferent messages define new approaches to treat obesity. Annu Rev Pharmacol Toxicol 2005, 45: 119-46. (Pubitemid 40261800)
4. Klaus S. Adipose tissue as a regulator of energy balance. Curr Drug Targets 2004, 5: 241-50. (Pubitemid 38372310)
5. Kershaw EE, Flier JS. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 2004, 89: 2548-56. (Pubitemid 38766330)
6. Cypess AM, Lehman S, Williams G, et al. Identification and importance of brown adipose tissue in adult humans. N Engl J Med 2009, 360: 1509-17.
7. Virtanen KA, Lidell ME, Orava J et al. Functional brown adipose tissue in healthy adults. N Engl J Med 2009, 360: 1518-25.
8. van Marken Lichtenbelt WD, Vanhommerig JW, Smulders NM, et al. Cold-activated brown adipose tissue in healthy men. N Engl J Med 2009, 360: 1500-8.
9. Cannon B, Nedergaard J. Metabolic consequences of the presence or absence of the thermogenic capacity of brown adipose tissue in mice (and probably in humans). Int J Obes (Lond) 2010, 34 (Suppl 1): S7-16.
10. Karpe F, Fielding BA, Ilic V, Macdonald IA, Summers LK, Frayn KN. Impaired postprandial adipose tissue blood flow response is related to aspects of insulin sensitivity. Diabetes 2002, 51: 2467-73. (Pubitemid 34827395)
11. West DB, Prinz WA, Francendese AA, Greenwood MR. Adipocyte blood flow is decreased in obese Zucker rats. Am J Physiol 1987, 253: R228-33.
12. Pang C, Gao Z, Yin J, Zhang J, Jia W, Ye J. Macrophage infiltration into adipose tissue may promote angiogenesis for adipose tissue remodeling in obesity. Am J Physiol Endocrinol Metab 2008, 295: E313-22.
13. Engeli S, Negrel R, Sharma AM. Physiology and pathophysiology of the adipose tissue renin-angiotensin system. Hypertension 2000, 35: 1270-7. (Pubitemid 30413663)
14. Blüher M, Wilson-Fritch L, Leszyk J, Laustsen PG, Corvera S, Kahn CR. Role of insulin action and cell size on protein expression patterns in adipocytes. J Biol Chem 2004, 279: 31902-9. (Pubitemid 39037863)
15. Hosogai N, Fukuhara A, Oshima K, et al. Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes 2007, 56: 901-11. (Pubitemid 46525054)
16. Ye J, Gao Z, Yin J, He Q. Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. Am J Physiol Endocrinol Metab 2007, 293: E1118-28. (Pubitemid 47535846)
17. Rausch ME, Weisberg S, Vardhana P, Tortoriello DV. Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration. Int J Obes (Lond) 2008, 32: 451-63. (Pubitemid 351414814)
18. Klein J, Fasshauer M, Ito M, Lowell BB, Benito M, Kahn CR. beta (3)-adrenergic stimulation differentially inhibits insulin signaling and decreases insulin-induced glucose uptake in brown adipocytes. J Biol Chem 1999, 274: 34795-802. (Pubitemid 129509523)
19. Lolmède K, Durand de Saint Front V, Galitzky J, Lafontan M, Bouloumié A. Effects of hypoxia on the expression of proangiogenic factors in differentiated 3T3-F442A adipocytes. Int J Obes Relat Metab Disord 2003, 27: 1187-95. (Pubitemid 37281666)
20. Wang B, Wood IS, Trayhurn P. Dysregulation of the expression and secretion of inflammation-related adipokines by hypoxia in human adipocytes. Pflugers Arch 2007, 455: 479-92. (Pubitemid 47624196)
21. Grundy SM, Brewer HB Jr, Cleeman JI, Smith SC Jr, Lenfant C; American Heart Association; National Heart, Lung, and Blood In sti tute. Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation 2004, 109: 433-8. (Pubitemid 38133916)
22. Marques BG, Hausman DB, Martin RJ. Association of fat cell size and paracrine growth factors in development of hyperplastic obesity. Am J Physiol 1998, 275: R1898-908.
23. Ye J. Emerging role of adipose tissue hypoxia in obesity and insulin resistance. Int J Obes (Lond) 2009, 33: 54-66.
24. Gregor MF, Hotamisligil GS. Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease. J Lipid Res 2007, 48: 1905-14. (Pubitemid 47360610)
25. Küchler S, Perwitz N, Schick RR, Klein J, Westphal S. Arginine-vasopressin directly promotes a thermogenic and pro-inflammatory adipokine expression profile in brown adipocytes. Regul Pept 2010, 164: 126-32.
26. Iwen KA, Senyaman O, Schwartz A, et al. Melanocortin crosstalk with adipose functions: ACTH directly induces insulin resistance, promotes a pro-inflammatory adipokine profile and stimulates UCP-1 in adipocytes. J Endocrinol 2008, 196: 465-72. (Pubitemid 351425502)
27. Westphal S, Perwitz N, Iwen KA, et al. Expression of ATRAP in adipocytes and negative regulation by beta-adrenergic stimulation of JAK/STAT. Horm Metab Res 2008, 40: 165-71. (Pubitemid 351690519)
28. Semenza GL, Wang GL. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 1992, 12: 5447-54.
29. Wree A, Kahraman A, Gerken G, Canbay A. Obesity affects the liver - the link between adipocytes and hepatocytes. Digestion 2011, 83: 124-33.
30. Wang B, Wood IS, Trayhurn P. Hypoxia induces leptin gene expression and secretion in human preadipocytes: differential effects of hypoxia on adipokine expression by preadipocytes. J Endocrinol 2008, 198: 127-34. (Pubitemid 352038192)
31. Nikami H, Nedergaard J, Fredriksson JM. Norepinephrine but not hypoxia stimulates HIF-1alpha gene expression in brown adipocytes. Biochem Biophys Res Commun 2005, 337: 121-6. (Pubitemid 41393766)
32. Lihn AS, Pedersen SB, Richelsen B. Adiponectin: action, regulation and association to insulin sensitivity. Obes Rev 2005, 6: 13-21.
33. Hotta K, Funahashi T, Arita Y, et al. Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol 2000, 20: 1595-9. (Pubitemid 30353893)
34. Okamoto Y, Kihara S, Funahashi T, Matsuzawa Y, Libby P. Adiponectin: a key adipocytokine in metabolic syndrome. Clin Sci (Lond) 2006, 110: 267-78. (Pubitemid 43341630)
35. Hui JM, Hodge A, Farrell GC, Kench JG, Kriketos A, George J. Beyond insulin resistance in NASH: TNF-alpha or adiponectin? Hepatology 2004, 40: 46-54. (Pubitemid 38868922)
36. Wedemeyer I, Bechmann LP, Odenthal M, et al. Adiponectin inhibits steatotic CD95/Fas up-regulation by hepatocytes: therapeutic implications for hepatitis C. J Hepatol 2009, 50: 140-9.
37. Chen B, Lam KS, Wang Y, et al. Hypoxia dysregulates the production of adiponectin and plasminogen activator inhibitor-1 independent of reactive oxygen species in adipocytes. Biochem Biophys Res Commun 2006, 341: 549-56. (Pubitemid 43152139)
38. Natarajan R, Salloum FN, Fisher BJ, Kukreja RC, Fowler AA. Hypoxia inducible factor-1 upregulates adiponectin in diabetic mouse hearts and attenuates post-ischemic injury. J Cardiovasc Pharmacol 2008, 51: 178-87. (Pubitemid 351301479)
39. Fujimoto N, Matsuo N, Sumiyoshi H, et al. Adiponectin is expressed in the brown adipose tissue and surrounding immature tissues in mouse embryos. Biochim Biophys Acta 2005, 1731: 1-12.
40. Haynes WG, Morgan DA, Walsh SA, Mark AL, Sivitz WI. Receptor-mediated regional sympathetic nerve activation by leptin. J Clin Invest 1997, 100: 270-8. (Pubitemid 27349073)
41. Grosfeld A, Zilberfarb V, Turban S, André J, Guerre-Millo M, Issad T. Hypoxia increases leptin expression in human PAZ6 adipose cells. Diabetologia 2002, 45: 527-30. (Pubitemid 34533831)
42. Ambrosini G, Nath AK, Sierra-Honigmann MR, Flores-Riveros J. Transcriptional activation of the human leptin gene in response to hypoxia. Involvement of hypoxia-inducible factor 1. J Biol Chem 2002, 277: 34601-9.
43. Shweiki D, Itin A, Soffer D, Keshet E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 1992, 359: 843-5.
44. Phillips MI, Speakman EA, Kimura B. Levels of angiotensin and molecular biology of the tissue renin angiotensin systems. Regul Pept 1993, 43: 1-20.
45. Engeli S, Böhnke J, Gorzelniak K, et al. Weight loss and the reninangiotensin-aldosterone system. Hypertension 2005, 45: 356-62.