Distinct in vitro binding properties of the anti-CD20 small modular immunopharmaceutical 2LM20-4 result in profound and sustained in vivo potency in cynomolgus monkeys.

Rheumatology (Oxford, England)

Volumn 50, Issue 6, 2011, Pages 1033-1044

  Nickerson Nutter, Cheryl ^a   Tchistiakova, Lioudmila ^b   Seth, Nilufer P ^b   Kasaian, Marion ^b   Sibley, Barbara ^b   Olland, Stephane ^b   Zollner, Richard ^b   Brady, William A ^b   Mohler, Kendall M ^b   Baum, Peter ^b   Wahl, Alan ^b   Herber, Deborah ^b   Vugmeyster, Yulia ^b   Wensel, David ^b   Wolfman, Neil M ^b   Gill, Davinder ^b   Collins, Mary ^b   Dunussi Joannopoulos, Kyri ^b  

^a PFIZER INC   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD20 ANTIGEN; IMMUNOLOGIC FACTOR; MONOCLONAL ANTIBODY; RITUXIMAB; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY;

ANIMAL; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ARTICLE; B LYMPHOCYTE; BINDING SITE; CELL CULTURE; COMPARATIVE STUDY; DISEASE MODEL; DRUG EFFECT; HUMAN; IMMUNOLOGY; IN VITRO STUDY; MACACA FASCICULARIS; METABOLISM; RANDOMIZATION; SENSITIVITY AND SPECIFICITY; STATISTICAL MODEL;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, MONOCLONAL, MURINE-DERIVED; ANTIBODY-DEPENDENT CELL CYTOTOXICITY; ANTIGENS, CD20; B-LYMPHOCYTES; BINDING SITES; CELLS, CULTURED; DISEASE MODELS, ANIMAL; HUMANS; IMMUNOLOGIC FACTORS; LINEAR MODELS; MACACA FASCICULARIS; RANDOM ALLOCATION; SENSITIVITY AND SPECIFICITY; SINGLE-CHAIN ANTIBODIES;

EID: 84863965582     PISSN: None     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/keq423     Document Type: Article

References (0)