Loss of insulin-induced activation of TRPM6 magnesium channels results in impaired glucose tolerance during pregnancy

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 28, 2012, Pages 11324-11329

  Nair, Anil V ^a   Hocherb, Berthold ^b,c,d   Verkaart, Sjoerd ^a   Van Zeeland, Femke ^a   Pfab, Thiemo ^c,e   Slowinski, Torsten ^c,e   Chen, You Peng ^c,f   Schlingmann, Karl Peter ^g   Schaller, André ^h   Gallati, Sabina ^h   Bindels, René J ^a   Konrad, Martin ^g   Hoenderop, Joost G ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF POTSDAM   (Germany)

^c DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^d Research and Early Development   (Switzerland)

^e CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^f JINAN UNIVERSITY   (China)

^g UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^h UNIVERSITY OF BERN   (Switzerland)

Author keywords

Distal convoluted tubule; Kidney; Transient receptor potential; Vesicular trafficking

Indexed keywords

CYCLIN DEPENDENT KINASE 5; GLYCOSYLATED HEMOGLOBIN; INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN VARIANT; RAC1 PROTEIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL M6;

AMINO ACID SUBSTITUTION; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE; CELL SURFACE; CHANNEL GATING; EMBRYO; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FEMALE; FETUS; FLUORESCENCE MICROSCOPY; GENETIC VARIABILITY; GLYCEMIC CONTROL; HEMOGLOBIN BLOOD LEVEL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMPAIRED GLUCOSE TOLERANCE; MAJOR CLINICAL STUDY; MOUSE; NONHUMAN; PATCH CLAMP; PREGNANCY DIABETES MELLITUS; PREGNANT WOMAN; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM;

CELL LINE; CYTOSKELETON; DIABETES, GESTATIONAL; FEMALE; GENE EXPRESSION REGULATION; GENETIC VARIATION; GENOTYPE; GLUCOSE; HEK293 CELLS; HUMANS; INSULIN; KIDNEY; MICROSCOPY, FLUORESCENCE; MODELS, BIOLOGICAL; PATCH-CLAMP TECHNIQUES; PHOSPHORYLATION; PREGNANCY; SIGNAL TRANSDUCTION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TRPM CATION CHANNELS;

EID: 84863938534     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1113811109     Document Type: Article

References (33)

1. Reece EA, Leguizamón G, Wiznitzer A (2009) Gestational diabetes: The need for a common ground. Lancet 373:1789-1797.
2. Bellamy L, Casas JP, Hingorani AD, Williams D (2009) Type 2 diabetes mellitus after gestational diabetes: A systematic review and meta-analysis. Lancet 373:1773-1779.
3. Jovanovic-Peterson L, Peterson CM (1996) Vitamin and mineral deficiencies which may predispose to glucose intolerance of pregnancy. J Am Coll Nutr 15:14-20.
4. Bardicef M, et al. (1996) Perinatal cellular ion metabolism: 31P-nuclear magnetic resonance spectroscopic analysis of intracellular free magnesium and pH in maternal and cord blood erythrocytes. J Soc Gynecol Investig 3:66-70.
5. Barbagallo M, Dominguez LJ (2007) Magnesium metabolism in type 2 diabetes mellitus, metabolic syndrome and insulin resistance. Arch Biochem Biophys 458:40-47. (Pubitemid 46186226)
6. Barbagallo M, et al. (2003) Role of magnesium in insulin action, diabetes and cardiometabolic syndrome X. Mol Aspects Med 24:39-52. (Pubitemid 36092143)
7. Song Y, Manson JE, Buring JE, Liu S (2004) Dietary magnesium intake in relation to plasma insulin levels and risk of type 2 diabetes in women. Diabetes Care 27:59-65. (Pubitemid 38196710)
8. Volpe SL (2008) Magnesium, the metabolic syndrome, insulin resistance, and type 2 diabetes mellitus. Crit Rev Food Sci Nutr 48:293-300.
9. Wilson FH, et al. (2004) A cluster of metabolic defects caused by mutation in a mitochondrial tRNA. Science 306:1190-1194. (Pubitemid 39489000)
10. Meyer TE, et al.; Genetic Factors for Osteoporosis Consortium; Meta Analysis of Glucose and Insulin Related Traits Consortium (2010) Genome-wide association studies of serum magnesium, potassium, and sodium concentrations identify six Loci influencing serum magnesium levels. PLoS Genet 6:e1001045.
11. Song Y, et al. (2009) Common genetic variants of the ion channel transient receptor potential membrane melastatin 6 and 7 (TRPM6 and TRPM7), magnesium intake, and risk of type 2 diabetes in women. BMC Med Genet 10:4.
12. Paolisso G, Barbagallo M (1997) Hypertension, diabetes mellitus, and insulin resistance: The role of intracellular magnesium. Am J Hypertens 10:346-355. (Pubitemid 27128280)
13. Hocher B, et al. (2009) Fetal sex determines the impact of maternal PROGINS progesterone receptor polymorphism on maternal physiology during pregnancy. Pharmacogenet Genomics 19:710-718.
14. Pfab T, et al. (2006) Low birth weight, a risk factor for cardiovascular diseases in later life, is already associated with elevated fetal glycosylated hemoglobin at birth. Circulation 114:1687-1692. (Pubitemid 44607116)
15. Dai LJ, et al. (2001) Magnesium transport in the renal distal convoluted tubule. Physiol Rev 81:51-84.
16. Schäffer L, et al. (2008) A novel high-affinity peptide antagonist to the insulin receptor. Biochem Biophys Res Commun 376:380-383.
17. Cao G, et al. (2008) RACK1 inhibits TRPM6 activity via phosphorylation of the fused alpha-kinase domain. Curr Biol 18:168-176.
18. Kitamura T, Kahn CR, Accili D (2003) Insulin receptor knockout mice. Annu Rev Physiol 65:313-332. (Pubitemid 38249156)
19. Cantley LC (2002) The phosphoinositide 3-kinase pathway. Science 296:1655-1657.
20. Bezzerides VJ, Ramsey IS, Kotecha S, Greka A, Clapham DE (2004) Rapid vesicular translocation and insertion of TRP channels. Nat Cell Biol 6:709-720. (Pubitemid 39144476)
21. Sumita C, et al. (2005) Platelet activating factor induces cytoskeletal reorganization through Rho family pathway in THP-1 macrophages. FEBS Lett 579:4038-4042. (Pubitemid 40961908)
22. Thebault S, Alexander RT, Tiel Groenestege WM, Hoenderop JG, Bindels RJ (2009) EGF increases TRPM6 activity and surface expression. J Am Soc Nephrol 20:78-85.
23. Yeung T, et al. (2006) Receptor activation alters inner surface potential during phagocytosis. Science 313:347-351. (Pubitemid 44480958)
24. Rosales JL, Lee KY (2006) Extraneuronal roles of cyclin-dependent kinase 5. Bioessays 28:1023-1034. (Pubitemid 44570451)
25. Lalioti V, et al. (2009) The atypical kinase Cdk5 is activated by insulin, regulates the association between GLUT4 and E-Syt1, and modulates glucose transport in 3T3-L1 adipocytes. Proc Natl Acad Sci USA 106:4249-4253.
26. Symons M, Rusk N (2003) Control of vesicular trafficking by Rho GTPases. Curr Biol 13:R409-R418. (Pubitemid 36573246)
27. Hisanaga E, et al. (2009) Regulation of calcium-permeable TRPV2 channel by insulin in pancreatic beta-cells. Diabetes 58:174-184.
28. Kjos SL, Buchanan TA (1999) Gestational diabetes mellitus. N Engl J Med 341:1749-1756.
29. Kirii K, Iso H, Date C, Fukui M, Tamakoshi A; JACC Study Group (2010) Magnesium intake and risk of self-reported type 2 diabetes among Japanese. J Am Coll Nutr 29:99-106.
30. Villegas R, et al. (2009) Dietary calcium and magnesium intakes and the risk of type 2 diabetes: The Shanghai Women's Health Study. Am J Clin Nutr 89:1059-1067.
31. James MF (2010) Magnesium in obstetrics. Best Pract Res Clin Obstet Gynaecol 24:327-337.
32. Kinne RK, Castaneda F (2011) SGLT inhibitors as new therapeutic tools in the treatment of diabetes. Handb Exp Pharmacol 1900:105-126.
33. Abdul-Ghani MA, Norton L, Defronzo RA (2011) Role of sodium-glucose cotransporter 2 (SGLT 2) inhibitors in the treatment of type 2 diabetes. Endocr Rev 32:515-531.