Overexpression of a novel cell cycle regulator ecdysoneless in breast cancer: A marker of poor prognosis in HER2/neu-overexpressing breast cancer patients

Breast Cancer Research and Treatment

Volumn 134, Issue 1, 2012, Pages 171-180

  Zhao, Xiangshan ^a   Mirza, Sameer ^a   Alshareeda, Alaa ^b   Zhang, Ying ^c   Gurumurthy, Channabasavaiah Basavaraju ^a   Bele, Aditya ^a   Kim, Jun Hyun ^a   Mohibi, Shakur ^a   Goswami, Monica ^d   Lele, Subodh M ^e   West, William ^e   Qiu, Fang ^a   Ellis, Ian O ^b   Rakha, Emad A ^b   Green, Andrew R ^b   Band, Hamid ^a,e   Band, Vimla ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^c Abbott Molecular Inc   (United States)

^d TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^e UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Breast cancer; Cell cycle; DCIS; Ecdysoneless; HER2 neu; IDC

Indexed keywords

ECD PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; TUMOR MARKER; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ARTICLE; BREAST CANCER; BREAST CARCINOMA; BREAST HYPERPLASIA; CANCER GRADING; CANCER GROWTH; CANCER PROGNOSIS; CANCER SPECIFIC SURVIVAL; COHORT ANALYSIS; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE FREE SURVIVAL; DISEASE MARKER; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; INTRADUCTAL CARCINOMA; MAJOR CLINICAL STUDY; MITOSIS INDEX; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; NOTTINGHAM PROGNOSTIC INDEX; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADOLESCENT; ADULT; AGED; ANTIBODY SPECIFICITY; BREAST; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CARCINOMA, INTRADUCTAL, NONINFILTRATING; CARRIER PROTEINS; COHORT STUDIES; DISEASE-FREE SURVIVAL; FEMALE; GENE EXPRESSION; HUMANS; HYPERPLASIA; KAPLAN-MEIER ESTIMATE; MIDDLE AGED; PROGNOSIS; RECEPTOR, ERBB-2; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 84863925514     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-011-1946-8     Document Type: Article

References (26)

1. DM Parkin F Bray J Ferlay P Pisani 2005 Global cancer statistics, 2002 CA Cancer J Clin 55 2 74 108 15761078 10.3322/canjclin.55.2.74
2. CJ Sherr 1996 Cancer cell cycles Science 274 5293 1672 1677 8939849 10.1126/science.274.5293.1672 1:CAS:528:DyaK28XntlyktLs%3D
3. I Sanchez BD Dynlacht 2005 New insights into cyclins, CDKs, and cell cycle control Semin Cell Dev Biol 16 3 311 321 10.1016/j.semcdb.2005.02.007 15840440 10.1016/j.semcdb.2005.02.007 1:CAS:528:DC%2BD2MXjsVemsLw%3D
4. A Sun L Bagella S Tutton G Romano A Giordano 2007 From G0 to S phase: a view of the roles played by the retinoblastoma (Rb) family members in the Rb-E2F pathway J Cell Biochem 102 6 1400 1404 10.1002/jcb.21609 17979151 10.1002/jcb.21609 1:CAS:528:DC%2BD2sXhsVeitL7O
5. M Malumbres M Barbacid 2005 Mammalian cyclin-dependent kinases Trends Biochem Sci 30 11 630 641 10.1016/j.tibs.2005.09.005 16236519 10.1016/j.tibs.2005.09.005 1:CAS:528:DC%2BD2MXhtFKhsLvE
6. PW Hinds S Mittnacht V Dulic A Arnold SI Reed RA Weinberg 1992 Regulation of retinoblastoma protein functions by ectopic expression of human cyclins Cell 70 6 993 1006 1388095 10.1016/0092-8674(92)90249-C 1:CAS:528:DyaK38XmtlWht7c%3D
7. ME Ewen HK Sluss CJ Sherr H Matsushime J Kato DM Livingston 1993 Functional interactions of the retinoblastoma protein with mammalian D-type cyclins Cell 73 3 487 497 8343202 10.1016/0092-8674(93)90136-E 1:CAS:528:DyaK3sXks1Gqu7s%3D
8. HC Hwang BE Clurman 2005 Cyclin E in normal and neoplastic cell cycles Oncogene 24 17 2776 2786 10.1038/sj.onc.1208613 15838514 10.1038/sj.onc.1208613 1:CAS:528:DC%2BD2MXjtlehs7k%3D
9. D Resnitzky L Hengst SI Reed 1995 Cyclin A-associated kinase activity is rate limiting for entrance into S phase and is negatively regulated in G1 by p27Kip1 Mol Cell Biol 15 8 4347 4352 7623829 1:CAS:528:DyaK2MXntVGitLY%3D
10. W Du J Pogoriler 2006 Retinoblastoma family genes Oncogene 25 38 5190 5200 10.1038/sj.onc.1209651 16936737 10.1038/sj.onc.1209651 1:CAS:528: DC%2BD28Xos12nur0%3D
11. DL Burkhart J Sage 2008 Cellular mechanisms of tumour suppression by the retinoblastoma gene Nat Rev Cancer 8 9 671 682 10.1038/nrc2399 18650841 10.1038/nrc2399 1:CAS:528:DC%2BD1cXhtVWksLfP
12. A Deshpande P Sicinski PW Hinds 2005 Cyclins and cdks in development and cancer: a perspective Oncogene 24 17 2909 2915 10.1038/sj.onc.1208618 15838524 10.1038/sj.onc.1208618 1:CAS:528:DC%2BD2MXjtlehsLw%3D
13. IN Mammas G Sourvinos A Giannoudis DA Spandidos 2008 Human papilloma virus (HPV) and host cellular interactions Pathol Oncol Res POR 14 4 345 354 10.1007/s12253-008-9056-6 10.1007/s12253-008-9056-6 1:CAS:528: DC%2BD1MXjtVyisbc%3D
14. V Band 1998 The role of retinoblastoma and p53 tumor suppressor pathways in human mammary epithelial cell immortalization Int J Oncol 12 3 499 507 9472085 1:CAS:528:DyaK1cXitVSrsr0%3D
15. JH Kim CB Gurumurthy M Naramura Y Zhang AT Dudley L Doglio H Band V Band 2009 Role of mammalian Ecdysoneless in cell cycle regulation J Biol Chem 284 39 26402 26410 10.1074/jbc.M109.030551 19640839 10.1074/jbc.M109.030551 1:CAS:528:DC%2BD1MXhtFCgs7zL
16. DM Abd El-Rehim G Ball SE Pinder E Rakha C Paish JF Robertson D Macmillan RW Blamey IO Ellis 2005 High-throughput protein expression analysis using tissue microarray technology of a large well-characterised series identifies biologically distinct classes of breast cancer confirming recent cDNA expression analyses Int J Cancer 116 3 340 350 10.1002/ijc.21004 15818618 10.1002/ijc.21004 1:CAS:528:DC%2BD2MXmtl2ktb0%3D
17. CW Elston IO Ellis 1991 Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up Histopathology 19 5 403 410 1757079 10.1111/j.1365-2559.1991.tb00229.x 1:STN:280:DyaK38%2FpvVSltw%3D%3D
18. MH Galea RW Blamey CE Elston IO Ellis 1992 The Nottingham prognostic index in primary breast cancer Breast Cancer Res Treat 22 3 207 219 1391987 10.1007/BF01840834 1:STN:280:DyaK3s%2FgsVyisA%3D%3D
19. KS McCarty Jr LS Miller EB Cox J Konrath KS McCarty Sr 1985 Estrogen receptor analyses. Correlation of biochemical and immunohistochemical methods using monoclonal antireceptor antibodies Arch Pathol Lab Med 109 8 716 721 3893381
20. RL Camp M Dolled-Filhart DL Rimm 2004 X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization Clin Cancer Res 10 21 7252 7259 10.1158/1078-0432.CCR-04-0713 15534099 10.1158/1078-0432. CCR-04-0713 1:CAS:528:DC%2BD2cXpsVKltbc%3D
21. EA Rakha ME El-Sayed AR Green EC Paish DG Powe J Gee RI Nicholson AH Lee JF Robertson IO Ellis 2007 Biologic and clinical characteristics of breast cancer with single hormone receptor positive phenotype J Clin Oncol 25 30 4772 4778 10.1200/JCO.2007.12.2747 17876012 10.1200/JCO.2007.12.2747
22. EA Rakha TC Putti DM Abd El-Rehim C Paish AR Green DG Powe AH Lee JF Robertson IO Ellis 2006 Morphological and immunophenotypic analysis of breast carcinomas with basal and myoepithelial differentiation J Pathol 208 4 495 506 10.1002/path.1916 16429394 10.1002/path.1916 1:CAS:528:DC%2BD28XislCqt78%3D
23. JH Kim CB Gurumurthy H Band V Band 2010 Biochemical characterization of human Ecdysoneless reveals a role in transcriptional regulation Biol Chem 391 1 9 19 10.1515/BC.2010.004 19919181 10.1515/bc.2010.004 1:CAS:528: DC%2BC3cXhtFensg%3D%3D
24. Y Zhang J Chen CB Gurumurthy J Kim I Bhat Q Gao G Dimri SW Lee H Band V Band 2006 The human orthologue of Drosophila ecdysoneless protein interacts with p53 and regulates its function Cancer Res 66 14 7167 7175 10.1158/0008-5472. CAN-06-0722 16849563 10.1158/0008-5472.CAN-06-0722 1:CAS:528: DC%2BD28XmvFGktL0%3D
25. WJ Irvin Jr LA Carey 2008 What is triple-negative breast cancer? Eur J Cancer 44 18 2799 2805 10.1016/j.ejca.2008.09.034 19008097 10.1016/j.ejca.2008. 09.034 1:CAS:528:DC%2BD1cXhsVKltr%2FE
26. R Dent E Warner 2007 Screening for hereditary breast cancer Semin Oncol 34 5 392 400 10.1053/j.seminoncol.2007.07.002 17920893 10.1053/j.seminoncol. 2007.07.002