Microfluidic 3D cell culture: Potential application for tissue-based bioassays

Bioanalysis

Volumn 4, Issue 12, 2012, Pages 1509-1525

  Li, Xiujun ^a   Valadez, Alejandra V ^a   Zuo, Peng ^a   Nie, Zhihong ^b  

^a UNIVERSITY OF TEXAS AT EL PASO   (United States)

^b University of Maryland   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACCURACY; ANIMAL CELL CULTURE; BIOASSAY; CANCER CELL CULTURE; CELL DIFFERENTIATION; CONCENTRATION (PARAMETERS); CULTURE TECHNIQUE; EMBRYONIC STEM CELL; EXTRACELLULAR MATRIX; HEART CELL CULTURE; HUMAN; HUMAN CELL CULTURE; LIVER CELL CULTURE; MESENCHYMAL STEM CELL; MICROENVIRONMENT; MICROFLUIDIC ANALYSIS; MICROFLUIDICS; MICROTECHNOLOGY; NERVE CELL CULTURE; NONHUMAN; PROCESS OPTIMIZATION; REVIEW; STRUCTURE ANALYSIS; UMBILICAL VEIN ENDOTHELIAL CELL;

ANIMALS; BIOLOGICAL ASSAY; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; HEPATOCYTES; HUMANS; MICE; MICROFLUIDICS; MYOCYTES, CARDIAC; NEURONS; NIH 3T3 CELLS; RATS; STEM CELLS; TISSUE ENGINEERING;

EID: 84863898664     PISSN: 17576180     EISSN: 17576199     Source Type: Journal    
DOI: 10.4155/bio.12.133     Document Type: Review

References (88)

1. Marimuthu M, Kim S. Microfluidic cell co-culture methods for understanding cell biology, analyzing bio/pharmaceuticals, and developing tissue constructs. Anal. Biochem. 413(2), 81-89 (2011
2. Elliott NT, Yuan F. A review of three-dimensional in vitro tissue models for drug discovery and transport studies. J. Pharm. Sci. 100(1), 59-74 (2011
3. Chen SY, Hung PJ, Lee PJ. Microfluidic array for three-dimensional perfusion culture of human mammary epithelial cells. Biomed. Microdevices 13(4), 753-758 (2011
4. Agastin S, Giang UB, Geng Y, Delouise LA, King MR. Continuously perfused microbubble array for 3D tumor spheroid model. Biomicrofluidics 5(2), 24110 (2011
5. Hsiao AY, Torisawa YS, Tung YC et al. Microfluidic system for formation of PC-3 prostate cancer co-culture spheroids. Biomaterials 30(16), 3020-3027 (2009
6. Musick K, Khatami D, Wheeler BC. Three-dimensional micro-electrode array for recording dissociated neuronal cultures. Lab Chip 9(14), 2036-2042 (2009
7. Minchinton AI, Tannock IF. Drug penetration in solid tumours. Nat. Rev. Cancer 6(8), 583-592 (2006
8. Martinez AW, Phillips ST, Whitesides GM. Three-dimensional microfluidic devices fabricated in layered paper and tape. Proc. Natl Acad. Sci. USA 105(50), 19606-19611 (2008
9. Yamada KM, Cukierman E. Modeling tissue morphogenesis and cancer in 3D. Cell 130(4), 601-610 (2007
10. Ong SM, Zhang C, Toh YC et al. A gel-free 3D microfluidic cell culture system. Biomaterials 29(22), 3237-3244 (2008
11. Gottwald E, Giselbrecht S, Augspurger C et al. A chip-based platform for the in vitro generation of tissues in three-dimensional organization. Lab Chip 7(6), 777-785 (2007
12. Golden AP, Tien J. Fabrication of microfluidic hydrogels using molded gelatin as a sacrificial element. Lab Chip 7(6), 720-725 (2007
13. Jang K, Sato K, Igawa K, Chung UI, Kitamori T. Development of an osteoblast-based 3D continuous-perfusion microfluidic system for drug screening. Anal. Bioanal. Chem. 390(3), 825-832 (2008
14. Toh YC, Lim TC, Tai D, Xiao G, van Noort D, Yu H. A microfluidic 3D hepatocyte chip for drug toxicity testing. Lab Chip 9(14), 2026-2035 (2009
15. Jungreuthmayer C, Jaasma MJ, Al-Munajjed AA, Zanghellini J, Kelly DJ, O'Brien FJ. Deformation simulation of cells seeded on a collagen-GAG scaffold in a flow perfusion bioreactor using a sequential 3D CFD-elastostatics model. Med. Eng. Phys. 31(4), 420-427 (2009
16. Sung KE, Su G, Pehlke C et al. Control of 3-dimensional collagen matrix polymerization for reproducible human mammary fibroblast cell culture in microfluidic devices. Biomaterials 30(27), 4833-4841 (2009
17. Zhang C, Chia SM, Ong SM et al. The controlled presentation of TGF-beta1 to hepatocytes in a 3D-microfluidic cell culture system. Biomaterials 30(23-24), 3847-3853 (2009
18. Carrion B, Huang CP, Ghajar CM et al. Recreating the perivascular niche ex vivo using a microfluidic approach. Biotechnol. Bioeng. 107(6), 1020-1028 (2010
19. Cuchiara MP, Allen AC, Chen TM, Miller JS, West JL. Multilayer microfluidic PEGDA hydrogels. Biomaterials 31(21), 5491-5497 (2010
20. Choi J, Kim S, Jung J et al. Wnt5a-mediating neurogenesis of human adipose tissue-derived stem cells in a 3D microfluidic cell culture system. Biomaterials 32(29), 7013-7022 (2011
21. Prot JM, Aninat C, Griscom L et al. Improvement of HepG2/C3a cell functions in a microfluidic biochip. Biotechnology Bioengineering 108(7), 1704-1715 (2011
22. Pampaloni F, Reynaud EG, Stelzer EHK. The third dimension bridges the gap between cell culture and live tissue. Nat. Rev. Mol. Cell. Bio. 8(10), 839-845 (2007
23. Garcia-Fuentes M, Meinel AJ, Hilbe M, Meinel L, Merkle HP. Silk fibroin/hyaluronan scaffolds for human mesenchymal stem cell culture in tissue engineering. Biomaterials 30(28), 5068-5076 (2009
24. Meinel AJ, Kubow KE, Klotzsch E et al. Optimization strategies for electrospun silk fibroin tissue engineering scaffolds. Biomaterials 30(17), 3058-3067 (2009
25. Li XJ, Li PCH. Strategies for the real-time detection of Ca2+ channel events of single cells: Recent advances and new possibilities. Expert Rev. Clin. Pharmacol. 3, 267-280 (2010
26. Salieb-Beugelaar GB, Simone G, Arora A, Philippi A, Manz A. Latest developments in microfluidic cell biology and analysis systems. Anal. Chem. 82(12), 4848-4864 (2010
27. Kovarik ML, Gach PC, Ornoff DM et al. Micro total analysis systems for cell biology and biochemical assays. Anal. Chem. 84(2), 516-540 (2012
28. Li XJ, Li PCH. Microfluidic selection and retention of a single cardiac myocyte, on-chip dye loading, cell contraction by chemical stimulation, and quantitative fluorescent analysis of intracellular calcium. Anal. Chem. 77(14), 4315-4322 (2005
29. Di Carlo D, Lee LP. Dynamic single-cell analysis for quantitative biology. Anal. Chem. 78(23), 7918-7925 (2006
30. Li XJ, Li PCH. Contraction study of a single cardiac muscle cell in a microfluidic chip. Methods Mol. Biol. 321, 199-225 (2006
31. Liu P, Li XJ, Greenspoon SA, Scherer JR, Mathies RA. Integrated DNA purification, PCR, sample cleanup, and capillary electrophoresis microchip for forensic human identification. Lab Chip 11(6), 1041-1048 (2011
32. Blazej RG, Kumaresan P, Mathies RA. Microfabricated bioprocessor for integrated nanoliter-scale Sanger DNA sequencing. Proc. Natl Acad. Sci. USA 103(19), 7240-7245 (2006
33. Li XJ, Nie ZH, Cheng C-M, Goodale AB, Whitesides GM. Paper-based electrochemical ELISA. Proc. Micro Total Analysis Systems 14, 1487-1489 (2010
34. Wheeler AR, Throndset WR, Whelan RJ et al. Microfluidic device for single-cell analysis. Anal. Chem. 75(14), 3581-3586 (2003
35. Li X, Chen Y, Li PC. A simple and fast microfluidic approach of same-single-cell analysis (SASCA) for the study of multidrug resistance modulation in cancer cells. Lab Chip 11(7), 1378-1384 (2011
36. Li XJ, Ling V, Li PCH. Same-single-cell analysis for the study of drug efflux modulation of multidrug resistant cells using a microfluidic chip. Anal. Chem. 80(11), 4095-4102 (2008
37. Li XJ, Chen Y, Li PCH. Modulation of multidrug resistance on the same single cancer cell in a microfluidic chip: Intended for cancer stem cell research. In: CANCER Stem Cells - The Cutting Edge. Shostak S (Ed.). InTech, Croatia, 529-554 (2011
38. Li XJ, Xue X, Li PCH. Real-time detection of the early event of cytotoxicity of herbal ingredients on single leukemia cells studied in a microfluidic biochip. Integr. Biol. 1(1), 90-98 (2009
39. Li XJ, Huang J, Tibbits GF, Li PCH. Real-time monitoring of intracellular calcium dynamic mobilization of a single cardiomyocyte in a microfluidic chip pertaining to drug discovery. Electrophoresis 28(24), 4723-4733 (2007
40. Derda R, Laromaine A, Mammoto A et al. Paper-supported 3D cell culture for tissue-based bioassays. Proc. Natl Acad. Sci. USA 106(44), 18457-18462 (2009
41. Meyvantsson I, Beebe DJ. Cell culture models in microfluidic systems. Annu. Rev. Anal. Chem. 1, 423-449 (2008
42. Khademhosseini A, Langer R, Borenstein J, Vacanti JP. Microscale technologies for tissue engineering and biology. Proc. Natl Acad. Sci. USA 103(8), 2480-2487 (2006
43. Hossler FE, Douglas JE, Douglas LE. Anatomy and morphometry of myocardial capillaries studied with vascular corrosion casting and scanning electron microscopy: a method for rat heart. Scan Electron. Microsc. (Pt 4), 1469-1475 (1986
44. Li PCH, Li XJ. Microfluidic lab-on-A-chip. In: Ewing's Analytical Instrumentation Handbook. Cazes J (Ed.). Marcel Dekker, NY 581-680 (2005
45. Li PCH. Microfluidic Lab-On-A-Chip for Chemical and Biological Analysis and Discovery. CRC Taylor & Francis, NY, USA (2006
46. Su WT Liao YF Lin CY Li LT. Micropillar substrate influences the cellular attachment and laminin expression J. Biomed. Mater. Res. A 93A(4), 1463-1469 (2010
47. Ling Y, Rubin J, Deng Y et al. A cell-laden microfluidic hydrogel. Lab Chip 7(6), 756-762 (2007
48. Ziolkowska K, Jedrych E, Kwapiszewski R, Lopacinska J, Skolimowski M, Chudy M. PDMS/glass microfluidic cell culture system for cytotoxicity tests and cells passage. Sensor. Actuat. B Chem. 145(1), 533-542 (2010
49. Lin JL Wang SS Wu MH Oh-Yang CC. Development of an integrated microfluidic perfusion cell culture system for real-time microscopic observation of biological cells. Sensors Basel 11(9), 8395-8411 (2011
50. Webster A, Dyer CE, Haswell SJ, Greenman J. A microfluidic device for tissue biopsy culture and interrogation. Anal. Methods-Uk. 2(8), 1005-1007 (2010
51. Xia Y, Whitesides GM. Soft lithography. Annu. Rev. Mater. Sci. 28, 153-184 (1998
52. Ni M, Tong WH, Choudhury D, Rahim NA, Iliescu C, Yu H. Cell culture on MEMS platforms: a review. Int. J. Mol. Sci. 10(12), 5411-5441 (2009
53. Ma LA Zhou CC Lin BY Li W. A porous 3D cell culture micro device for cell migration study. Biomed. Microdevices 12(4), 753-760 (2010
54. Ng CP, Pun SH. A perfusable 3D cell-matrix tissue culture chamber for in situ evaluation of nanoparticle vehicle penetration and transport. Biotechnology Bioengineering 99(6), 1490-1501 (2008
55. Trkov S, Eng G, Di Liddo R, Parnigotto PP, Vunjak-Novakovic G. Micropatterned three-dimensional hydrogel system to study human endothelial-mesenchymal stem cell interactions. J. Tissue Engin. Reg. Med. 4(3), 205-215 (2010
56. Kunze A, Valero A, Zosso D, Renaud P. Synergistic NGF/B27 gradients position synapses heterogeneously in 3D micropatterned neural cultures. PloS One 6(10), e26187 (2011
57. Sung KE, Yang N, Pehlke C et al. Transition to invasion in breast cancer: a microfluidic in vitro model enables examination of spatial and temporal effects. Integrative Biology: Quantitative Biosciences from Nano to Macro 3(4), 439-450 (2011
58. Elliott N, Lee T, You L, Yuan F. Proliferation behavior of E. coli in a three-dimensional in vitro tumor model. Integrative Biology: Quantitative Biosciences From Nano to Macro 3(6), 696-705 (2011
59. Montanez-Sauri SI, Sung KE, Puccinelli JP, Pehlke C, Beebe DJ. Automation of three-dimensional cell culture in arrayed microfluidic devices. J. Laboratory Automation 16(3), 171-185 (2011
60. Toh YC, Zhang C, Zhang J et al. A novel 3D mammalian cell perfusion-culture system in microfluidic channels. Lab Chip 7(3), 302-309 (2007
61. Vickerman V, Blundo J, Chung S, Kamm R. Design, fabrication and implementation of a novel multi-parameter control microfluidic platform for three-dimensional cell culture and real-time imaging. Lab Chip 8(9), 1468-1477 (2008
62. Zhang C, Zhao Z, Abdul Rahim NA, van oort D, Yu H. Towards a human-on-chip: culturing multiple cell types on a chip with compartmentalized microenvironments. Lab Chip 9(22), 3185-3192 (2009
63. Schutte J Hagmeyer B Holzner F et al. Artificial micro organs-A microfluidic device for dielectrophoretic assembly of liver sinusoids Biomed. Microdevices. 13. 3. 493-501. 2011
64. Figallo E, Cannizzaro C, Gerecht S et al. Micro-bioreactor array for controlling cellular microenvironments. Lab Chip 7(6), 710-719 (2007
65. Derda R, Tang SK, Laromaine A et al. Multizone paper platform for 3D cell cultures. PloS One 6(5), e18940 (2011
66. Jeong GS, Kwon GH, Kang AR et al. Microfluidic assay of endothelial cell migration in 3D interpenetrating polymer semi-network HA-collagen hydrogel. Biomed. Microdevices 13(4), 717-723 (2011
67. Hwang CM, Khademhosseini A, Park Y, Sun K, Lee SH. Microfluidic chip-based fabrication of PLGA microfiber scaffolds for tissue engineering. Langmuir 24(13), 6845-6851 (2008
68. Wan CR, Chung S, Kamm RD. Differentiation of embryonic stem cells into cardiomyocytes in a compliant microfluidic system. Ann. Biomed. Engin. 39(6), 1840-1847 (2011
69. Wong AP, Perez-Castillejos R, Christopher Love J, Whitesides GM. Partitioning microfluidic channels with hydrogel to construct tunable 3-D cellular microenvironments. Biomaterials 29(12), 1853-1861 (2008
70. Vukasinovic J, Cullen DK, LaPlaca MC, Glezer A. A microperfused incubator for tissue mimetic 3D cultures. Biomed. Microdevices 11(6), 1155-1165 (2009
71. Kunze A, Giugliano M, Valero A, Renaud P. Micropatterning neural cell cultures in 3D with a multi-layered scaffold. Biomaterials 32(8), 2088-2098 (2011
72. Sivagnanam V, Song B, Vandevyver C, Bunzli JC, Gijs MA. Selective breast cancer cell capture, culture, and immunocytochemical analysis using self-assembled magnetic bead patterns in a microfluidic chip. Langmuir 26(9), 6091-6096 (2010
73. Tuch BE. Stem cells - a clinical update. Aust. Fam. Physician 35(9), 719-721 (2006
74. Prot JM, Briffaut AS, Letourneur F et al. Integrated proteomic and transcriptomic investigation of the acetaminophen toxicity in liver microfluidic biochip. PloS One 6(8), e21268 (2011
75. Hattersley SM, Greenman J, Haswell SJ. Study of ethanol induced toxicity in liver explants using microfluidic devices. Biomed. Microdevices 13(6), 1005-1014 (2011
76. Rambani K, Vukasinovic J, Glezer A, Potter SM. Culturing thick brain slices: An interstitial 3D microperfusion system for enhanced viability. J. Neurosci. Methods 180(2), 243-254 (2009
77. Kunze A, Bertsch A, Giugliano M, Renaud P. Microfluidic hydrogel layers with multiple gradients to stimulate and perfuse three-dimensional neuronal cell cultures. Procedia Chem. 1(1), 369-372 (2009
78. Kanagasabapathi TT, Ciliberti D, Martinoia S, Wadman WJ, Decre MM. Dual-compartment neurofluidic system for electrophysiological measurements in physically segregated and functionally connected neuronal cell culture. Frontiers in Neuroengineering 4, 13 (2011
79. Tekin H, Ozaydin-Ince G, Tsinman T et al. Responsive microgrooves for the formation of harvestable tissue constructs. Langmuir 27(9), 5671-5679 (2011
80. Korin N, Bransky A, Khoury M, Dinnar U, Levenberg S. Design of well and groove microchannel bioreactors for cell culture. Biotechnol. Bioengin. 102(4), 1222-1230 (2009
81. Liu T, Lin B, Qin J. Carcinoma-associated fibroblasts promoted tumor spheroid invasion on a microfluidic 3D co-culture device. Lab Chip 10(13), 1671-1677 (2010
82. Huh D, Hamilton GA, Ingber DE. From 3D cell culture to organs-on-chips. Trends Cell Biol. 21(12), 745-754 (2011
83. McGuigan AP, Sefton MV. Vascularized organoid engineered by modular assembly enables blood perfusion. Proc. Natl Acad. Sci. USA 103(31), 11461-11466 (2006
84. Bruzewicz DA, McGuigan AP, Whitesides GM. Fabrication of a modular tissue construct in a microfluidic chip. Lab Chip 8(5), 663-671 (2008
85. Javaherian S, O'Donnell KA, McGuigan AP. A Fast and accessible methodology for micro-patterning cells on standard culture substrates using parafilm inserts. PloS One 6(6) (2011
86. Fernandez JG, Khademhosseini A. Micro-masonry: Construction of 3D structures by microscale self-assembly. Adv. Mater. 22(23), 2538-2541 (2010
87. Guillotin B, Guillemot F. Cell patterning technologies for organotypic tissue fabrication. Trends Biotechnol. 29(4), 183-190 (2011
88. Huh D, Matthews BD, Mammoto A, Montoya-Zavala M, Hsin HY, Ingber DE. Reconstituting organ-level lung functions on a chip. Science 328(5986), 1662-1668 (2010)