Phase-sensitive imaging of the outer retina using optical coherence tomography and adaptive optics

Biomedical Optics Express

Volumn 3, Issue 1, 2012, Pages 104-124

  Jonnal, Ravi S ^a   Kocaoglu, Omer P ^b   Wang, Qiang ^b   Lee, Sangyeol ^b   Miller, Donald T ^a,b  

^a INDIANA UNIVERSITY   (United States)

^b INDIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OPTICAL CONSTANTS; OPTICS;

AXIAL DISPLACEMENTS; AXIAL RESOLUTIONS; CONE PHOTORECEPTORS; ELONGATION RATES; EX-VIVO; NOVEL TECHNIQUES; OCT SIGNALS; OPTICAL PATH LENGTHS; OUTER SEGMENTS; PHASE DIFFERENCE; PHASE IMAGING; PHASE INFORMATION; PHASE SENSITIVE IMAGING; PHASE SENSITIVITY; PHASE-SENSITIVE; RETINAL ECCENTRICITY; SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY; SUBRESOLUTION; THREE-DIMENSIONAL RESOLUTION;

OPTICAL TOMOGRAPHY;

EID: 84863891099     PISSN: None     EISSN: 21567085     Source Type: Journal    
DOI: 10.1364/BOE.3.000104     Document Type: Article

References (29)

1. D. T. Miller, D. Williams, G. Morris, and J. Liang, "Images of cone photoreceptors in the living human eye," Vision Res. 36, 1067-1079 (1996).
2. J. Liang, D. R. Williams, and D. T. Miller, "Supernormal vision and high-resolution retinal imaging through adaptive optics," J. Opt. Soc. Am. A 14, 2884-2892 (1997).
3. D. Williams, "Imaging single cells in the living retina." Vision Res. (2011).
4. E. Fernández, B. Povazay, B. Hermann, A. Unterhuber, H. Sattmann, P. Prieto, R. Leitgeb, P. Ahnelt, P. Artal, and W. Drexler, "Three-dimensional adaptive optics ultrahigh-resolution optical coherence tomography using a liquid crystal spatial light modulator," Vision Res. 45, 3432-3444 (2005).
5. Y. Zhang, J. Rha, R. S. Jonnal, and D. T. Miller, "Adaptive optics parallel spectral domain optical coherence tomography for imaging the living retina," Opt. Express 13, 4792-4811 (2005).
6. R. Zawadzki, S. Jones, S. Olivier, M. Zhao, B. Bower, J. Izatt, S. Choi, S. Laut, and J. Werner, "Adaptive-optics optical coherence tomography for high-resolution and high-speed 3d retinal in vivo imaging," Opt. Express 13, 8532-8546 (2005).
7. Y. Zhang, B. Cense, J. Rha, R. S. Jonnal, W. Gao, R. J. Zawadzki, J. S. Werner, S. Jones, S. Olivier, and D. T. Miller, "High-speed volumetric imaging of cone photoreceptors with adaptive optics spectral-domain optical coherence tomography," Opt. Express 14, 4380-4394 (2006).
8. R. Zawadzki, B. Cense, Y. Zhang, S. Choi, D. Miller, and J. Werner, Ultrahigh-resolution optical coherence tomography with monochromatic and chromatic aberration correction," Opt. Express 16, 8126-8143 (2008).
9. E. Fernández, B. Hermann, B. Považay, A. Unterhuber, H. Sattmann, B. Hofer, P. Ahnelt, and W. Drexler, "Ultrahigh resolution optical coherence tomography and pancorrection for cellular imaging of the living human retina," Opt. Express 16, 11083-11094 (2008).
10. W. Gao, Y. Zhang, B. Cense, R. S. Jonnal, J. Rha, and D. Miller, "Measuring retinal contributions to the optical Stiles-Crawford effect with optical coherence tomography," Opt. Express 16, 6486-501 (2008).
11. M. Pircher, E. Götzinger, O. Findl, S. Michels, W. Geitzenauer, C. Leydolt, U. Schmidt-Erfurth, and C. Hitzenberger, "Human macula investigated in vivo with polarization-sensitive optical coherence tomography," Invest. Ophth. Vis. Sci. 47, 5487 (2006).
12. B. Cense, W. Gao, J. M. Brown, S. M. Jones, R. S. Jonnal, M. Mujat, B. H. Park, J. F. de Boer, and D. T. Miller, "Retinal imaging with polarization-sensitive optical coherence tomography and adaptive optics," Opt. Express 17, 21634-21651 (2009).
13. O. P. Kocaoglu, S. Lee, R. S. Jonnal, Q. Wang, A. E. Herde, J. C. Derby, W. Gao, and D. T. Miller, "Imaging cone photoreceptors in three dimensions and in time using ultrahigh resolution optical coherence tomography with adaptive optics," Biomed. Opt. Express 2, 748-763 (2011).
14. R. S. Jonnal, J. Rha, Y. Zhang, B. Cense, W. Gao, and D. T. Miller, "In vivo functional imaging of human cone photoreceptors," Opt. Express 15, 16141-16160 (2007).
15. R. S. Jonnal, J. R. Besecker, J. C. Derby, O. P. Kocaoglu, B. Cense, W. Gao, Q. Wang, and D. T. Miller, "Imaging outer segment renewal in living human cone photoreceptors," Opt. Express 18, 5257-5270 (2010).
16. M. Pircher, J. Kroisamer, F. Felberer, H. Sattmann, E. Götzinger, and C. Hitzenberger, Temporal changes of human cone photoreceptors observed in vivo with slo/oct," Biomed. Opt. Express 2, 100-112 (2011).
17. O. P. Kocaoglu, S. Lee, R. S. Jonnal, Q. Wang, A. E. Herde, J. R. Besecker, W. Gao, and D. T. Miller, "3D imaging of cone photoreceptors over extended time periods using optical coherence tomography with adaptive optics," Proc. SPIE 7885, 78850C (2011),.
18. T. Akkin, D. P. Davé, T. E. Milner, and H. G. Rylander III, "Detection of neural activity using phase-sensitive optical low-coherence reflectometry," Opt. Express 12, 2377-2386 (2004).
19. M. Choma, A. Ellerbee, C. Yang, T. Creazzo, and J. Izatt, "Spectral-domain phase microscopy," Opt. Lett. 30, 1162-1164 (2005).
20. C. Joo, T. Akkin, B. Cense, B. Park, and J. de Boer, "Spectral-domain optical coherence phase microscopy for quantitative phase-contrast imaging," Opt. Lett. 30, 2131-2133 (2005).
21. J. Izatt, M. Kulkarni, S. Yazdanfar, J. Barton, and A. Welch, "In vivo bidirectional color doppler flow imaging of picoliter blood volumes using optical coherence tomography," Opt. Lett. 22, 1439-1441 (1997).
22. R. Leitgeb, L. Schmetterer, W. Drexler, A. Fercher, R. Zawadzki, and T. Bajraszewski, "Real-time assessment of retinal blood flow with ultrafast acquisition by color doppler fourier domain optical coherence tomography," Opt. Express 11, 3116-3121 (2003).
23. S. Makita, Y. Hong, M. Yamanari, T. Yatagai, and Y. Yasuno, "Optical coherence angiography," Opt. Express 14, 7821-7840 (2006).
24. B. Cense, E. Koperda, J. M. Brown, O. P. Kocaoglu, W. Gao, R. S. Jonnal, and D. T. Miller, "Volumetric retinal imaging with ultrahigh-resolution spectral-domain optical coherence tomography and adaptive optics using two broadband light sources," Opt. Express 17, 4095-4111 (2009).
25. A. Snyder, "Stiles-crawford effect-explanation and consequences," Vision Res. 13, 1115-1137 (1972).
26. C. Curcio, K. Sloan, R. Kalina, and A. Hendrickson, "Human photoreceptor topography." J. Comp. Neurol. 292, 497-523 (1990).
27. R. S. Jonnal, J. R. Besecker, J. C. Derby, O. P. Kocaoglu, W. Gao, and D. T. Miller, Imaging outer segment renewal in living human cone photoreceptors, presented at ARVO Annual Meeting (2010), Abstract 51:2933.
28. D. Anderson, S. Fisher, and R. Steinberg, "Mammalian cones: disc shedding, phagocytosis, and renewal," Invest. Ophth. Vis. Sci. 17, 117-133 (1978).
29. S. Beucher and F. Meyer, "The morphological approach to segmentation: the watershed transformation," Opt. Eng. 34, 433-433 (1992).