Skin sealant InteguSeal ® has no impact on prevention of postoperative mediastinitis after cardiac surgery

Journal of Hospital Infection

Volumn 81, Issue 4, 2012, Pages 278-282

  Waldow, T ^a   Szlapka, M ^a   Hensel, J ^a   Plotze K ^a   Matschke, K ^a   Jatzwauk, L ^b  

^a University Heart Center Dresden   (Germany)

^b UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

Author keywords

Elective cardiac surgery; Median sternotomy; Mediastinitis; Skin sealant; Surgical site infection

Indexed keywords

ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; CYANOACRYLATE; INOTROPIC AGENT; INTEGUSEAL; SEALANT; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CHRONIC LUNG DISEASE; DIABETES MELLITUS; DISEASE COURSE; ELECTIVE SURGERY; FEMALE; FOLLOW UP; HEART SURGERY; HOSPITAL DISCHARGE; HOSPITALIZATION; HUMAN; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MEDIASTINITIS; OBESITY; OPERATION DURATION; PERIOPERATIVE PERIOD; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; RISK FACTOR; SEPSIS; SKIN INCISION; STERNOTOMY; SURGICAL INFECTION; SURGICAL TECHNIQUE; TUBE;

AGED; ANTI-INFECTIVE AGENTS, LOCAL; CYANOACRYLATES; HUMANS; INCIDENCE; MALE; MEDIASTINITIS; MIDDLE AGED; SKIN; SURGICAL WOUND INFECTION; THORACIC SURGERY; TISSUE ADHESIVES; TREATMENT OUTCOME;

EID: 84863883715     PISSN: 01956701     EISSN: 15322939     Source Type: Journal    
DOI: 10.1016/j.jhin.2012.04.024     Document Type: Article

References (23)

1. Lepelletier D., Perron S., Bizouarn P., et al. Surgical site infection after cardiac surgery: incidence, microbiology, and risk factors. Infect Control Hosp Epidemiol 2005, 26:466-472.
2. Risnes I., Abdelnoor M., Almdahl S.M., Svennevig J.L. Mediastinitis after coronary artery bypass grafting. Risk factors and long-term survival. Ann Thorac Surg 2010, 89:1502-1510.
3. Diez C., Koch D., Kuss O., Silber R.E., Friedrich I., Boergermann J. Risk factors for mediastinitis after cardiac surgery - a retrospective analysis of 1700 patients. J Cardiothorac Surg 2007, 2:23.
4. Omran A.S., Karimi A., Ahmadi S.H., et al. Superficial and deep sternal wound infection after more than 9000 coronary artery bypass graft (CABG): incidence, risk factors and mortality. BMC Infect Dis 2007, 7:112.
5. Dohmen P.M., Konertz W. A review of current strategies to reduce intraoperative bacterial contamination of surgical wounds. GMS Krankenhhyg Interdiszip 2007, 2:Doc38.
6. Jakob H.G., Borneff-Lipp M., Bach A., et al. The endogenous pathway is a major route for deep sternal wound infection. Eur J Cardiothoracic Surg 2000, 17:154-160.
7. Wilson S.E. Microbial sealing: a new approach to reducing contamination. J Hosp Infect 2008, 70(Suppl. 2):11-14.
8. Horan T.C., Gaynes R.P., Martone W.J., Jarvis W.R., Emori T.G. CDC definitions of nosocomial surgical site infections, 1992: a modification of CDC definitions of surgical wound infections. Infect Control Hosp Epidemiol 1992, 13:606-608.
9. Horan T.C., Andrus M., Dudeck M.A. CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control 2008, 36:309-332.
10. Waldow T., Krutzsch D., Wils M., Plötze K., Matschke K. Low dose aprotinin and low dose tranexamic acid in elective cardiac surgery with cardiopulmonary bypass. Clin Hemorheol Microcirc 2009, 42:269-277.
11. Surgical site infection. Prevention and treatment of surgical site infection. NICE clinical guideline 74 October 2008, National Institute for Health and Clinical Excellence, National Collaborating Centre for Women's and Children's Health, London.
12. Empfehlung der Kommission für Krankenhaushygiene und Infektionsprävention beim Robert Koch-Institut. Bundesgesundheitsbl-Gesundheitsforch-Gesundheitsschutz 2007, 50:377-393. Prävention postoperativer Infektionen im Operationsgebiet.
13. Mangram A.J., Horan T.C., Pearson M.L., Silver L.C., Jarvis W.R. Guideline for prevention of surgical site infection, 1999. Centers for Disease Control and Prevention (CDC) Hospital Infection Control Practices Advisory Committee. Am J Infect Control 1999, 27:97-132.
14. Fowler V.G., O'Brien S.M., Muhlbaier L.H., Coray G.R., Ferguson T.B., Peterson E.D. Clinical predictors of major infections after cardiac surgery. Circulation 2005, 112(9 Suppl.):I358-I365.
15. Moet G.J., Jones R.N., Biedenbach D.J., Stilwell M.G., Fritsche T.R. Contemporary causes of skin and soft tissue infections in North America, Latin America, and Europe: Report from the SENTRY Antimicrobial Surveillance Program (1998-2004). Diagn Microbiol Infect Dis 2007, 57:7-13.
16. Diana M., Hübner M., Eisenring M.-C., Zanetti G., Troillet N., Demartines N. Measures to prevent surgical site infections: what surgeons (should) do. Wld J Surg 2011, 35:280-288.
17. Dohmen P.M., Gabbieri D., Weymann A., Linneweber J., Konertz W. Reduction in surgical site infection in patients treated with microbial sealant prior to coronary artery bypass graft surgery: a case-control study. J Hosp Infect 2009, 72:119-126.
18. Dohmen P.M. Influence of skin flora and preventive measures on surgical site infection during cardiac surgery. Surg Infect (Larchmt) 2006, 7(Suppl. 1):S13-S17.
19. Saadatian-Elahi M., Teyssou R., Vanhems P. Staphylococcus aureus, the major pathogen in orthopaedic and cardiac surgical site infections: a literature review. Int J Surg 2008, 6:238-245.
20. Silva von Eckardstein A., Lim C.H., Dohmen P.M., et al. A randomized trial of a skin sealant to reduce the risk of incision contamination in cardiac surgery. Ann Thorac Surg 2011, 92:632-637.
21. Darouiche R.O., Wall M.J., Itani K.M.F., et al. Chlorhexidine-alcohol versus povidone-iodine for surgical-site antisepsis. N Engl J Med 2010, 362:18-26.
22. Dohmen P.M., Weymann A., Holinski S., Linneweber J., Geyer T., Konertz W. Use of an antimicrobial skin sealant reduces surgical site infection in patients undergoing routine cardiac surgery. Surg Infect (Larchmt) 2011, 12:475-481.
23. Dohmen P.M., Gabbieri D., Weymann A., Linneweber J., Geyer T., Konertz W. A retrospective non-randomized study on the impact of Integuseal, a preoperative microbial skin sealant, on the rate of surgical site infections after cardiac surgery. Int J Infect Dis 2011, 15:395-400.