MicroRNA signature in diabetic wound healing: Promotive role of miR-21 in fibroblast migration

International Wound Journal

Volumn 9, Issue 4, 2012, Pages 355-361

  Madhyastha, R ^a   Madhyastha, H ^a   Nakajima, Y ^a   Omura, S ^a   Maruyama, M ^a  

^a UNIVERSITY OF MIYAZAKI   (Japan)

Author keywords

Diabetic wound healing; Fibroblast; MicroRNA; Migration; MiR 21

Indexed keywords

MICRORNA; MICRORNA 10B; MICRORNA 128; MICRORNA 146B; MICRORNA 20B; MICRORNA 21; MICRORNA 452; MICRORNA 541; MICRORNA 96; RNA; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CELL MIGRATION; CONTROLLED STUDY; FIBROBLAST; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; WOUND HEALING;

ANIMALS; CELL MOVEMENT; CELLS, CULTURED; DIABETES MELLITUS, TYPE 2; DIABETIC FOOT; DISEASE MODELS, ANIMAL; FIBROBLASTS; GENE EXPRESSION REGULATION; MALE; MICE; MICE, INBRED STRAINS; MICRORNAS; NEOVASCULARIZATION, PHYSIOLOGIC; RANDOM ALLOCATION; REAL-TIME POLYMERASE CHAIN REACTION; REFERENCE VALUES; SENSITIVITY AND SPECIFICITY; TRANSFECTION; WOUND HEALING;

EID: 84863876809     PISSN: 17424801     EISSN: 1742481X     Source Type: Journal    
DOI: 10.1111/j.1742-481X.2011.00890.x     Document Type: Article

References (33)

1. Karp X, Ambros V. Developmental biology. Encountering microRNAs in cell fate signaling. Science 2005;310:1288-9.
2. Xu P, Guo M, Hay BA. MicroRNAs and the regulation of cell death. Trends Genet 2004;20:617-24.
3. Cheng AM, Byrom MW, Shelton J, Ford LP. Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis. Nucleic Acids Res 2005;33:1290-7.
4. Chen CZ, Li L, Lodish HF, Bartel DP. MicroRNAs modulate hematopoietic lineage differentiation. Science 2004;303:83-6.
5. Poliseno L, Tuccoli A, Mariani L, Evangelista M, Citti L, Woods K, Mercatanti A, Hammond S, Rainaldi G. MicroRNAs modulate the angiogenic properties of HUVECs. Blood 2006;108:3068-71.
6. Garzon R, Fabbri M, Cimmino A, Calin GA, Croce CM. MicroRNA expression and function in cancer. Trends Mol Med 2006;12:580-7.
7. Falanga V. Wound healing and its impairment in the diabetic foot. Lancet 2005;366:1736-43.
8. Blakytny R, Jude E. The molecular biology of chronic wounds and delayed healing in diabetes. Diabet Med 2006;23:594-608.
9. Moriyama T, Ohuchida K, Mizumoto K, Yu J, Sato N, Nabae T, Takahata S, Toma H, Nagai E, Tanaka M. MicroRNA-21 modulates biological functions of pancreatic cancer cells including their proliferation, invasion, and chemoresistance. Mol Cancer Ther 2009;8:1067-74.
10. Sand M, Gambichler T, Sand D, Skrygan M, Altmeyer P, Bechara FG. MicroRNAs and the skin: tiny players in the body's largest organ. J Dermatol Sci 2009;53:169-75.
11. Bostjancic E, Glavac D. Importance of microRNAs in skin morphogenesis and diseases. Acta Dermatovenerol Alp Panonica Adriat 2008;17:95-102.
12. Madhyastha HK, Radha KS, Nakajima Y, Omura S, Maruyama M. uPA dependent and independent mechanisms of wound healing by C-phycocyanin. J Cell Mol Med 2008;12:2691-703.
13. Philippidou D, Schmitt M, Moser D, Margue C, Nazarov PV, Muller A, Vallar L, Nashan D, Behrmann I, Kreis S. Signatures of MicroRNAs and selected MicroRNA target genes in human melanoma. Cancer Res 2010;70:4163-73.
14. McAnulty RJ. Fibroblasts and myofibroblasts: their source, function and role in disease. Int J Biochem Cell Biol 2007;39:666-71.
15. Enoch S, Leaper DJ. Basic science of wound healing. Surgery 2005;23:6.
16. Krichevsky AM, Gabriely G. miR-21: a small multi-faceted RNA. J Cell Mol Med 2009;13:39-53.
17. Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST, Patel T. MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 2007;133:647-58.
18. Ribas J, Lupold SE. The transcriptional regulation of miR-21, its multiple transcripts, and their implication in prostate cancer. Cell Cycle 2010; 9:923-9.
19. Urbich C, Kuehbacher A, Dimmeler S. Role of microRNAs in vascular diseases, inflammation, and angiogenesis. Cardiovasc Res 2008;79:581-8.
20. Suarez Y, Fernandez-Hernando C, Yu J, Gerber SA, Harrison KD, Pober JS, Iruela-Arispe ML, Merkenschlager M, Sessa WC. Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis. Proc Natl Acad Sci U S A 2008;105:14082-7.
21. Shilo S, Roy S, Khanna S, Sen CK. MicroRNA in cutaneous wound healing: a new paradigm. DNA Cell Biol 2007;26:227-37.
22. Wang S, Aurora AB, Johnson BA, Qi X, McAnally J, Hill JA, Richardson JA, Bassel-Duby R, Olson EN. The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell 2008;15:261-71.
23. van Solingen C, Seghers L, Bijkerk R, Duijs JM, Roeten MK, van Oeveren-Rietdijk AM, Baelde HJ, Monge M, Vos JB, de Boer HC, Quax PH, Rabelink TJ, van Zonneveld AJ. Antagomir-mediated silencing of endothelial cell specific microRNA-126 impairs ischemia-induced angiogenesis. J Cell Mol Med 2009;13:1577-85.
24. Redell JB, Liu Y, Dash PK. Traumatic brain injury alters expression of hippocampal microRNAs: potential regulators of multiple pathophysiological processes. J Neurosci Res 2009;87:1435-48.
25. Sen CK, Gordillo GM, Khanna S, Roy S. Micromanaging vascular biology: tiny microRNAs play big band. J Vasc Res 2009;46:527-40.
26. Yin C, Wang X, Kukreja RC. Endogenous microRNAs induced by heat-shock reduce myocardial infarction following ischemia-reperfusion in mice. FEBS Lett 2008;582:4137-42.
27. Harris TA, Yamakuchi M, Ferlito M, Mendell JT, Lowenstein CJ. MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1. Proc Natl Acad Sci U S A 2008;105: 1516-21.
28. Sehm T, Sachse C, Frenzel C, Echeverri K. miR-196 is an essential early-stage regulator of tail regeneration, upstream of key spinal cord patterning events. Dev Biol 2009;334:468-80.
29. Baum CL, Arpey CJ. Normal cutaneous wound healing: clinical correlation with cellular and molecular events. Dermatol Surg 2005;31:674-86 (discussion 686).
30. Roy S, Khanna S, Hussain SR, Biswas S, Azad A, Rink C, Gnyawali S, Shilo S, Nuovo GJ, Sen CK. MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue. Cardiovasc Res 2009;82:21-9.
31. Zhao M. PTEN: a promising pharmacological target to enhance epithelial wound healing. Br J Pharmacol 2007;152:1141-4.
32. Papagiannakopoulos T, Shapiro A, Kosik KS. MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells. Cancer Res 2008;68:8164-72.
33. Kim YJ, Hwang SJ, Bae YC, Jung JS. MiR-21 regulates adipogenic differentiation through the modulation of TGF-beta signaling in mesenchymal stem cells derived from human adipose tissue. Stem Cells 2009;27:3093-102.