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Volumn 35, Issue 4, 2012, Pages 511-520

The androgen receptor CAG repeat polymorphism as a risk factor of low serum testosterone and its cardiometabolic effects in men

Author keywords

CAG repeat; Cardiometabolic risk factors; Longitudinal population based cohort; Metabolic syndrome; Testosterone

Indexed keywords

ANDROGEN RECEPTOR; TESTOSTERONE;

EID: 84863870397     PISSN: 01056263     EISSN: 13652605     Source Type: Journal    
DOI: 10.1111/j.1365-2605.2011.01220.x     Document Type: Article
Times cited : (21)

References (43)
  • 1
    • 2942665883 scopus 로고    scopus 로고
    • Laboratory markers carbohydrate-deficient transferrin, gamma-glutamyltransferase, and mean corpuscular volume are not useful as screening tools for high-risk drinking in the general population: results from the study of health in Pomerania (SHIP)
    • Alte D, Luedemann J, Rose HJ & John U. (2004) Laboratory markers carbohydrate-deficient transferrin, gamma-glutamyltransferase, and mean corpuscular volume are not useful as screening tools for high-risk drinking in the general population: results from the study of health in Pomerania (SHIP). Alcohol Clin Exp Res 28, 931-940.
    • (2004) Alcohol Clin Exp Res , vol.28 , pp. 931-940
    • Alte, D.1    Luedemann, J.2    Rose, H.J.3    John, U.4
  • 2
    • 34548742493 scopus 로고    scopus 로고
    • Part of the interindividual variation in serum testosterone levels in healthy men reflects differences in androgen sensitivity and feedback set point: contribution of the androgen receptor polyglutamine tract polymorphism
    • (2007)
    • Crabbe P, Bogaert V, De Bacquer D, Goemaere S, Zmierczak H & Kaufman JM. (2007) Part of the interindividual variation in serum testosterone levels in healthy men reflects differences in androgen sensitivity and feedback set point: contribution of the androgen receptor polyglutamine tract polymorphism. J Clin Endocrinol Metab 92, 3604-3610.
    • J Clin Endocrinol Metab , vol.92 , pp. 3604-3610
    • Crabbe, P.1    Bogaert, V.2    De Bacquer, D.3    Goemaere, S.4    Zmierczak, H.5    Kaufman, J.M.6
  • 4
    • 77951057449 scopus 로고    scopus 로고
    • Associations of anthropometric parameters with serum TSH, prolactin, IGF-I, and testosterone levels: results of the study of health in Pomerania (SHIP)
    • Friedrich N, Rosskopf D, Brabant G, Volzke H, Nauck M & Wallaschofski H. (2010) Associations of anthropometric parameters with serum TSH, prolactin, IGF-I, and testosterone levels: results of the study of health in Pomerania (SHIP). Exp Clin Endocrinol Diabetes 118, 266-273.
    • (2010) Exp Clin Endocrinol Diabetes , vol.118 , pp. 266-273
    • Friedrich, N.1    Rosskopf, D.2    Brabant, G.3    Volzke, H.4    Nauck, M.5    Wallaschofski, H.6
  • 6
    • 70449448370 scopus 로고    scopus 로고
    • AR CAG repeat length is not associated with serum gonadal steroids and lipid levels in healthy men
    • Goutou M, Sakka C, Stakias N, Stefanidis I & Koukoulis GN. (2009) AR CAG repeat length is not associated with serum gonadal steroids and lipid levels in healthy men. Int J Androl 32, 616-622.
    • (2009) Int J Androl , vol.32 , pp. 616-622
    • Goutou, M.1    Sakka, C.2    Stakias, N.3    Stefanidis, I.4    Koukoulis, G.N.5
  • 7
    • 0025884064 scopus 로고
    • Age, disease, and changing sex hormone levels in middle-aged men: results of the Massachusetts male aging study
    • Gray A, Feldman HA, McKinlay JB & Longcope C. (1991) Age, disease, and changing sex hormone levels in middle-aged men: results of the Massachusetts male aging study. J Clin Endocrinol Metab 73, 1016-1025.
    • (1991) J Clin Endocrinol Metab , vol.73 , pp. 1016-1025
    • Gray, A.1    Feldman, H.A.2    McKinlay, J.B.3    Longcope, C.4
  • 11
    • 70349105993 scopus 로고    scopus 로고
    • Prediction of metabolic syndrome by low serum testosterone levels in men: results from the study of health in Pomerania
    • Haring R, Volzke H, Felix SB, Schipf S, Dorr M, Rosskopf D, Nauck M, Schofl C & Wallaschofski H. (2009b) Prediction of metabolic syndrome by low serum testosterone levels in men: results from the study of health in Pomerania. Diabetes 58, 2027-2031.
    • (2009) Diabetes , vol.58 , pp. 2027-2031
    • Haring, R.1    Volzke, H.2    Felix, S.B.3    Schipf, S.4    Dorr, M.5    Rosskopf, D.6    Nauck, M.7    Schofl, C.8    Wallaschofski, H.9
  • 12
    • 78449296295 scopus 로고    scopus 로고
    • Prevalence, incidence and risk factors of testosterone deficiency in a population-based cohort of men: results from the study of health in Pomerania
    • Haring R, Ittermann T, Volzke H, Krebs A, Zygmunt M, Felix SB, Grabe HJ, Nauck M & Wallaschofski H. (2010a) Prevalence, incidence and risk factors of testosterone deficiency in a population-based cohort of men: results from the study of health in Pomerania. Aging Male 13, 247-257.
    • (2010) Aging Male , vol.13 , pp. 247-257
    • Haring, R.1    Ittermann, T.2    Volzke, H.3    Krebs, A.4    Zygmunt, M.5    Felix, S.B.6    Grabe, H.J.7    Nauck, M.8    Wallaschofski, H.9
  • 13
    • 77953734946 scopus 로고    scopus 로고
    • Low serum testosterone levels are associated with increased risk of mortality in a population-based cohort of men aged 20-79
    • Haring R, Volzke H, Steveling A, Krebs A, Felix SB, Schofl C, Dorr M, Nauck M & Wallaschofski H. (2010b) Low serum testosterone levels are associated with increased risk of mortality in a population-based cohort of men aged 20-79. Eur Heart J 31, 1494-1501.
    • (2010) Eur Heart J , vol.31 , pp. 1494-1501
    • Haring, R.1    Volzke, H.2    Steveling, A.3    Krebs, A.4    Felix, S.B.5    Schofl, C.6    Dorr, M.7    Nauck, M.8    Wallaschofski, H.9
  • 15
    • 0035097033 scopus 로고    scopus 로고
    • Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore longitudinal study of aging
    • Harman SM, Metter EJ, Tobin JD, Pearson J & Blackman MR. (2001) Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore longitudinal study of aging. J Clin Endocrinol Metab 86, 724-731.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 724-731
    • Harman, S.M.1    Metter, E.J.2    Tobin, J.D.3    Pearson, J.4    Blackman, M.R.5
  • 16
    • 23444459874 scopus 로고    scopus 로고
    • The CAG repeat polymorphism in the androgen receptor gene is associated with HDL-cholesterol but not with coronary atherosclerosis or myocardial infarction
    • Hersberger M, Muntwyler J, Funke H, Marti-Jaun J, Schulte H, Assmann G, Luscher TF & von Eckardstein A. (2005) The CAG repeat polymorphism in the androgen receptor gene is associated with HDL-cholesterol but not with coronary atherosclerosis or myocardial infarction. Clin Chem 51, 1110-1115.
    • (2005) Clin Chem , vol.51 , pp. 1110-1115
    • Hersberger, M.1    Muntwyler, J.2    Funke, H.3    Marti-Jaun, J.4    Schulte, H.5    Assmann, G.6    Luscher, T.F.7    von Eckardstein, A.8
  • 17
    • 58149400587 scopus 로고    scopus 로고
    • Increased estrogen rather than decreased androgen action is associated with longer androgen receptor CAG repeats
    • Huhtaniemi IT, Pye SR, Limer KL, Thomson W, O'Neill TW, Platt H et al. (2009) Increased estrogen rather than decreased androgen action is associated with longer androgen receptor CAG repeats. J Clin Endocrinol Metab 94, 277-284.
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 277-284
    • Huhtaniemi, I.T.1    Pye, S.R.2    Limer, K.L.3    Thomson, W.4    O'Neill, T.W.5    Platt, H.6
  • 19
    • 77952701998 scopus 로고    scopus 로고
    • Endogenous hormones, androgen receptor CAG repeat length and fluid cognition in middle-aged and older men: results from the European male ageing study
    • Lee DM, Ulubaev A, Tajar A, Pye SR, Pendleton N, Purandare N et al. (2010) Endogenous hormones, androgen receptor CAG repeat length and fluid cognition in middle-aged and older men: results from the European male ageing study. Eur J Endocrinol 162, 1155-1164.
    • (2010) Eur J Endocrinol , vol.162 , pp. 1155-1164
    • Lee, D.M.1    Ulubaev, A.2    Tajar, A.3    Pye, S.R.4    Pendleton, N.5    Purandare, N.6
  • 21
    • 77950320120 scopus 로고    scopus 로고
    • The impact of the cag repeat polymorphism of the androgen receptor gene on muscle and adipose tissues in 20-29-year-old danish men: odense androgen study
    • Nielsen TL, Hagen C, Wraae K, Bathum L, Larsen R, Brixen K & Andersen M. (2010) The impact of the cag repeat polymorphism of the androgen receptor gene on muscle and adipose tissues in 20-29-year-old danish men: odense androgen study. Eur J Endocrinol 162, 795-804.
    • (2010) Eur J Endocrinol , vol.162 , pp. 795-804
    • Nielsen, T.L.1    Hagen, C.2    Wraae, K.3    Bathum, L.4    Larsen, R.5    Brixen, K.6    Andersen, M.7
  • 23
    • 33747353010 scopus 로고    scopus 로고
    • The androgen receptor gene CAG repeat polymorphism does not predict increased risk of heart disease: longitudinal results from the Massachusetts male ageing study
    • Page ST, Kupelian V, Bremner WJ & McKinlay JB. (2006) The androgen receptor gene CAG repeat polymorphism does not predict increased risk of heart disease: longitudinal results from the Massachusetts male ageing study. Clin Endocrinol (Oxf) 65, 333-339.
    • (2006) Clin Endocrinol (Oxf) , vol.65 , pp. 333-339
    • Page, S.T.1    Kupelian, V.2    Bremner, W.J.3    McKinlay, J.B.4
  • 25
    • 38849091997 scopus 로고    scopus 로고
    • Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond
    • discussion 207-112
    • Pencina MJ, D'Agostino RB Sr, D'Agostino RB Jr & Vasan RS. (2008) Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Stat Med 27, 157-172; discussion 207-112.
    • (2008) Stat Med , vol.27 , pp. 157-172
    • Pencina, M.J.1    D'Agostino Sr., R.B.2    D'Agostino Jr., R.B.3    Vasan, R.S.4
  • 26
    • 0035859562 scopus 로고    scopus 로고
    • A score for predicting risk of death from cardiovascular disease in adults with raised blood pressure, based on individual patient data from randomised controlled trials
    • Pocock SJ, McCormack V, Gueyffier F, Boutitie F, Fagard RH & Boissel JP. (2001) A score for predicting risk of death from cardiovascular disease in adults with raised blood pressure, based on individual patient data from randomised controlled trials. BMJ 323, 75-81.
    • (2001) BMJ , vol.323 , pp. 75-81
    • Pocock, S.J.1    McCormack, V.2    Gueyffier, F.3    Boutitie, F.4    Fagard, R.H.5    Boissel, J.P.6
  • 27
    • 80051534845 scopus 로고    scopus 로고
    • Low total testosterone is associated with increased risk of incident type 2 diabetes mellitus in men: results from the study of health in Pomerania (SHIP)
    • Schipf S, Haring R, Friedrich N, Nauck MA, Lau K, Alte D, Stang A, Völzke H & Wallaschofski H. (2011) Low total testosterone is associated with increased risk of incident type 2 diabetes mellitus in men: results from the study of health in Pomerania (SHIP). Aging Male 14, 168-175.
    • (2011) Aging Male , vol.14 , pp. 168-175
    • Schipf, S.1    Haring, R.2    Friedrich, N.3    Nauck, M.A.4    Lau, K.5    Alte, D.6    Stang, A.7    Völzke, H.8    Wallaschofski, H.9
  • 28
    • 69249214281 scopus 로고    scopus 로고
    • Androgen receptor gene polymorphism and sex hormones in elderly men: the Tromso study
    • Skjaerpe PA, Giwercman YL, Giwercman A & Svartberg J. (2009) Androgen receptor gene polymorphism and sex hormones in elderly men: the Tromso study. Asian J Androl 11, 222-228.
    • (2009) Asian J Androl , vol.11 , pp. 222-228
    • Skjaerpe, P.A.1    Giwercman, Y.L.2    Giwercman, A.3    Svartberg, J.4
  • 29
    • 77951925160 scopus 로고    scopus 로고
    • Androgen receptor gene polymorphism and the metabolic syndrome in 60-80years old Norwegian men
    • Skjaerpe PA, Giwercman YL, Giwercman A & Svartberg J. (2010) Androgen receptor gene polymorphism and the metabolic syndrome in 60-80years old Norwegian men. Int J Androl 33, 500-506.
    • (2010) Int J Androl , vol.33 , pp. 500-506
    • Skjaerpe, P.A.1    Giwercman, Y.L.2    Giwercman, A.3    Svartberg, J.4
  • 30
    • 58149343861 scopus 로고    scopus 로고
    • Androgen receptor CAG repeat polymorphism is associated with serum testosterone levels, obesity and serum leptin in men with type 2 diabetes
    • Stanworth RD, Kapoor D, Channer KS & Jones TH. (2008) Androgen receptor CAG repeat polymorphism is associated with serum testosterone levels, obesity and serum leptin in men with type 2 diabetes. Eur J Endocrinol 159, 739-746.
    • (2008) Eur J Endocrinol , vol.159 , pp. 739-746
    • Stanworth, R.D.1    Kapoor, D.2    Channer, K.S.3    Jones, T.H.4
  • 31
    • 79953741235 scopus 로고    scopus 로고
    • Dyslipidaemia is associated with testosterone, oestradiol and androgen receptor CAG repeat polymorphism in men with type 2 diabetes
    • Stanworth RD, Kapoor D, Channer KS & Jones TH. (2011) Dyslipidaemia is associated with testosterone, oestradiol and androgen receptor CAG repeat polymorphism in men with type 2 diabetes. Clin Endocrinol (Oxf) 74, 624-630.
    • (2011) Clin Endocrinol (Oxf) , vol.74 , pp. 624-630
    • Stanworth, R.D.1    Kapoor, D.2    Channer, K.S.3    Jones, T.H.4
  • 34
    • 0035723790 scopus 로고    scopus 로고
    • Lack of influence of the androgen receptor gene CAG-repeat polymorphism on sex steroid status and bone metabolism in elderly men
    • Van Pottelbergh I, Lumbroso S, Goemaere S, Sultan C & Kaufman JM. (2001) Lack of influence of the androgen receptor gene CAG-repeat polymorphism on sex steroid status and bone metabolism in elderly men. Clin Endocrinol (Oxf) 55, 659-666.
    • (2001) Clin Endocrinol (Oxf) , vol.55 , pp. 659-666
    • Van Pottelbergh, I.1    Lumbroso, S.2    Goemaere, S.3    Sultan, C.4    Kaufman, J.M.5
  • 35
    • 0033305020 scopus 로고    scopus 로고
    • A critical evaluation of simple methods for the estimation of free testosterone in serum
    • Vermeulen A, Verdonck L & Kaufman JM. (1999) A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 84, 3666-3672.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 3666-3672
    • Vermeulen, A.1    Verdonck, L.2    Kaufman, J.M.3
  • 38
    • 47549107694 scopus 로고    scopus 로고
    • Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European male aging study
    • Wu FC, Tajar A, Pye SR, Silman AJ, Finn JD, O'Neill TW et al. (2008) Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European male aging study. J Clin Endocrinol Metab 93, 2737-2745.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 2737-2745
    • Wu, F.C.1    Tajar, A.2    Pye, S.R.3    Silman, A.J.4    Finn, J.D.5    O'Neill, T.W.6
  • 39
    • 59849123606 scopus 로고    scopus 로고
    • The role of the CAG repeat androgen receptor polymorphism in andrology
    • Zitzmann M. (2009) The role of the CAG repeat androgen receptor polymorphism in andrology. Front Horm Res, 37, 52-61.
    • (2009) Front Horm Res , vol.37 , pp. 52-61
    • Zitzmann, M.1
  • 40
    • 0037384830 scopus 로고    scopus 로고
    • The CAG repeat polymorphism within the androgen receptor gene and maleness
    • Zitzmann M & Nieschlag E. (2003) The CAG repeat polymorphism within the androgen receptor gene and maleness. Int J Androl 26, 76-83.
    • (2003) Int J Androl , vol.26 , pp. 76-83
    • Zitzmann, M.1    Nieschlag, E.2
  • 41
    • 0035724191 scopus 로고    scopus 로고
    • The CAG repeat polymorphism in the androgen receptor gene affects bone density and bone metabolism in healthy males
    • Zitzmann M, Brune M, Kornmann B, Gromoll J, Junker R & Nieschlag E. (2001a) The CAG repeat polymorphism in the androgen receptor gene affects bone density and bone metabolism in healthy males. Clin Endocrinol (Oxf) 55, 649-657.
    • (2001) Clin Endocrinol (Oxf) , vol.55 , pp. 649-657
    • Zitzmann, M.1    Brune, M.2    Kornmann, B.3    Gromoll, J.4    Junker, R.5    Nieschlag, E.6
  • 43
    • 0037280752 scopus 로고    scopus 로고
    • The CAG repeat polymorphism in the androgen receptor gene modulates body fat mass and serum concentrations of leptin and insulin in men
    • Zitzmann M, Gromoll J, von Eckardstein A & Nieschlag E. (2003) The CAG repeat polymorphism in the androgen receptor gene modulates body fat mass and serum concentrations of leptin and insulin in men. Diabetologia 46, 31-39.
    • (2003) Diabetologia , vol.46 , pp. 31-39
    • Zitzmann, M.1    Gromoll, J.2    von Eckardstein, A.3    Nieschlag, E.4


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