CD4+ T cell-mediated neuroprotection is independent of T cell-derived BDNF in a mouse facial nerve axotomy model

Brain, Behavior, and Immunity

Volumn 26, Issue 6, 2012, Pages 886-890

  Xin, Junping ^a,b   Mesnard, Nichole A ^a,b   Beahrs, Taylor ^a,b   Wainwright, Derek A ^c   Serpe, Craig J ^b   Alexander, Thomas D ^b   Sanders, Virginia M ^d   Jones, Kathryn J ^e  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

^b HINES VA HOSPITAL   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

^d THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^e INDIANA UNIVERSITY   (United States)

Author keywords

Brain derived neurotrophic factor; CD4; Conditional gene knockout; Facial nerve axotomy; Motoneuron survival; T cell

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; MESSENGER RNA;

ADOLESCENT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; FEMALE; MOTONEURON; MOUSE; NERVE FIBER TRANSECTION; NERVE INJURY; NEUROPROTECTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; WESTERN BLOTTING;

ANIMALS; AXOTOMY; BLOTTING, WESTERN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CD4-POSITIVE T-LYMPHOCYTES; CELL COUNT; CELL SURVIVAL; FACIAL NERVE INJURIES; FEMALE; FLOW CYTOMETRY; MICE; MICE, KNOCKOUT; MOTOR NEURONS; REAL-TIME POLYMERASE CHAIN REACTION; RNA;

EID: 84863866242     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2012.02.011     Document Type: Article

References (19)

1. Azoulay D., Urshansky N., Karni A. Low and dysregulated BDNF secretion from immune cells of MS patients is related to reduced neuroprotection. J. Neuroimmunol. 2008, 195:186-193.
2. De Santi L., Cantalupo L., Tassi M., Raspadori D., Cioni C., Annunziata P. Higher expression of BDNF receptor gp145trkB is associated with lower apoptosis intensity in T cell lines in multiple sclerosis. J. Neurol. Sci. 2009, 277:65-70.
3. De Santi L., Polimeni G., Cuzzocrea S., Esposito E., Sessa E., Annunziata P., Bramanti P. Neuroinflammation and neuroprotection: an update on (future) neurotrophin-related strategies in multiple sclerosis treatment. Curr. Med. Chem. 2011, 18:1775-1784.
4. Deboy C.A., Xin J., Byram S.C., Serpe C.J., Sanders V.M., Jones K.J. Immune-mediated neuroprotection of axotomized mouse facial motoneurons is dependent on the IL-4/STAT6 signaling pathway in CD4(+) T cells. Exp. Neurol. 2006, 201:212-224.
5. Edling A.E., Nanavati T., Johnson J.M., Tuohy V.K. Human and murine lymphocyte neurotrophin expression is confined to B cells. J. Neurosci. Res. 2004, 77:709-717.
6. Jones K.J., LaVelle A. Changes in nuclear envelope invaginations in axotomized immature and mature hamster facial motoneurons. Brain Res. 1985, 353:241-249.
7. Kerschensteiner M., Gallmeier E., Behrens L., Leal V.V., Misgeld T., Klinkert W.E., Kolbeck R., Hoppe E., Oropeza-Wekerle R.L., Bartke I., Stadelmann C., Lassmann H., Wekerle H., Hohlfeld R. Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation?. J. Exp. Med. 1999, 189:865-870.
8. Kondo S., Kishi H., Tokimitsu Y., Muraguchi A. Possible involvement of glial cell line-derived neurotrophic factor and its receptor, GFRalpha1, in survival and maturation of thymocytes. Eur. J. Immunol. 2003, 33:2233-2240.
9. Linker R.A., Lee D.H., Demir S., Wiese S., Kruse N., Siglienti I., Gerhardt E., Neumann H., Sendtner M., Luhder F., Gold R. Functional role of brain-derived neurotrophic factor in neuroprotective autoimmunity: therapeutic implications in a model of multiple sclerosis. Brain 2009, 133:2248-2263.
10. Maroder M., Bellavia D., Meco D., Napolitano M., Stigliano A., Alesse E., Vacca A., Giannini G., Frati L., Gulino A., Screpanti I. Expression of trKB neurotrophin receptor during T cell development. Role of brain derived neurotrophic factor in immature thymocyte survival. J. Immunol. 1996, 157:2864-2872.
11. Serpe C.J., Byram S.C., Sanders V.M., Jones K.J. Brain-derived neurotrophic factor supports facial motoneuron survival after facial nerve transection in immunodeficient mice. Brain Behav. Immun. 2005, 19:173-180.
12. + or B, lymphocytes mediate facial motoneuron survival after facial nerve transection. Brain Behav. Immun. 2003, 17:393-402.
13. Serpe, C.J., Kohm, A.P., Huppenbauer, C.B., Sanders, V.M., Jones, K.J., 1999. Exacerbation of facial motoneuron loss after facial nerve transection in severe combined immunodeficient (scid) mice. J. Neurosci. 19, RC7.
14. Wolf S.A., Steiner B., Akpinarli A., Kammertoens T., Nassenstein C., Braun A., Blankenstein T., Kempermann G. CD4-positive T lymphocytes provide a neuroimmunological link in the control of adult hippocampal neurogenesis. J Immunol 2009, 182:3979-3984.
15. Xin J., Wainwright D.A., Mesnard N.A., Serpe C.J., Sanders V.M., Jones K.J. IL-10 within the CNS is necessary for CD4(+) T cells to mediate neuroprotection. Brain Behav. Immun. 2011, 25:820-829.
16. + T cell subsets that develop following mouse facial nerve axotomy. Brain Behav. Immun. 2008, 22:528-537.
17. Zhao Z., Alam S., Oppenheim R.W., Prevette D.M., Evenson A., Parsadanian A. Overexpression of glial cell line-derived neurotrophic factor in the CNS rescues motoneurons from programmed cell death and promotes their long-term survival following axotomy. Exp. Neurol. 2004, 190:356-372.
18. Ziemssen T., Kumpfel T., Klinkert W.E., Neuhaus O., Hohlfeld R. Glatiramer acetate-specific T-helper 1- and 2-type cell lines produce BDNF: implications for multiple sclerosis therapy. Brain-derived neurotrophic factor. Brain 2002, 125:2381-2391.
19. Ziv Y., Ron N., Butovsky O., Landa G., Sudai E., Greenberg N., Cohen H., Kipnis J., Schwartz M. Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood. Nat. Neurosci. 2006, 9:268-275.