KCNQ1OT1 hypomethylation: A Novel disguised genetic predisposition in sporadic pediatric adrenocortical tumors?

Pediatric Blood and Cancer

Volumn 59, Issue 3, 2012, Pages 565-566

  Wijnen, Mark ^a   Alders, Mariëlle ^b   Zwaan, Christian M ^a   Wagner, Anja ^c   van den Heuvel Eibrink, Marry M ^a  

^a SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Adrenocortical tumors; Beckwith Wiedemann syndrome; Genetics; Pediatric oncology

Indexed keywords

ANDROGEN; CISPLATIN; CORTISONE; DOXORUBICIN; ESTRADIOL; ETOPOSIDE; MITOTANE; POTASSIUM CHANNEL KCNQ1; POTASSIUM CHANNEL KCNQ1OT1; TESTOSTERONE; UNCLASSIFIED DRUG;

ADOLESCENT; ADRENAL CORTEX ADENOMA; ADRENAL CORTEX CARCINOMA; ARTICLE; BECKWITH WIEDEMANN SYNDROME; CANCER RELAPSE; CANCER STAGING; CARCINOGENESIS; CASE REPORT; CHILD; CLINICAL FEATURE; CUSHING SYNDROME; DNA METHYLATION; FEMALE; GENETIC PREDISPOSITION; GENETIC SCREENING; HIGH BIRTH WEIGHT; HUMAN; HYPERTENSION; PHENOTYPE; PRIORITY JOURNAL; SCHOOL CHILD; SECONDARY AMENORRHEA; VIRILIZATION;

ADENOMA; ADOLESCENT; ADRENAL CORTEX NEOPLASMS; CARCINOMA; CHILD; DNA METHYLATION; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; POTASSIUM CHANNELS, VOLTAGE-GATED;

EID: 84863861364     PISSN: 15455009     EISSN: 15455017     Source Type: Journal    
DOI: 10.1002/pbc.23398     Document Type: Article

References (9)

1. Fruhwald MC, Witt O. The epigenetics of cancer in children. Klin Padiatr 2008; 220: 333-341.
2. Weksberg R, Shuman C, Beckwith JB. Beckwith-Wiedemann syndrome. Eur J Hum Genet 2010; 18: 8-14.
3. Scott RH, Douglas J, Baskcomb L, et al. Constitutional 11p15 abnormalities, including heritable imprinting center mutations, cause nonsyndromic wilms tumor. Nat Genet 2008; 40: 1329-1334.
4. McHugh K. Renal and adrenal tumours in children. Cancer Imaging 2007; 7: 41-51.
5. Ribeiro RC, Figueiredo B. Childhood adrenocortical tumours. Eur J Cancer 2004; 40: 1117-1126.
6. Alders M, Bliek J, vd Lip K, et al. Determination of KCNQ1OT1 and H19 methylation levels in bws and srs patients using methylation-sensitive high-resolution melting analysis. Eur J Hum Genet 2009; 17: 467-473.
7. Bliek J, Gicquel C, Maas S, et al. Epigenotyping as a tool for the prediction of tumor risk and tumor type in patients with Beckwith-Wiedemann syndrome (bws). J Pediatr 2004; 145: 796-799.
8. Alsultan A, Lovell MA, Hayes KL, et al. Simultaneous occurrence of right adrenocortical tumor and left adrenal neuroblastoma in an infant with Beckwith-Wiedemann syndrome. Pediatr Blood Cancer 2008; 51: 695-698.
9. Ehrlich M. DNA methylation in cancer: Too much, but also too little. Oncogene 2002; 21: 5400-5413.