Further analysis of the lens phenotype in Lim2-deficient mice

Investigative Ophthalmology and Visual Science

Volumn 52, Issue 10, 2011, Pages 7332-7339

  Shi, Yanrong ^a   De Maria, Alicia B ^a   Wang, Huan ^b   Mathias, Richard T ^b   FitzGerald, Paul G ^c   Bassnett, Steven ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONNEXIN 46; CONNEXIN 50; CP49; CYTOSKELETON PROTEIN; FILENSIN; GAP JUNCTION PROTEIN; LENS PROTEIN; LIM 2 PROTEIN; LIM PROTEIN; SPECTRIN; UNCLASSIFIED DRUG; VIMENTIN; EYE PROTEIN; LIM2 PROTEIN, MOUSE; MEMBRANE PROTEIN; PROTEOME;

ANIMAL TISSUE; ARTICLE; CELL COMMUNICATION; CELL FUSION; CELL MEMBRANE POTENTIAL; CELL STRUCTURE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOSKELETON; ELECTROPHYSIOLOGY; IMMUNOBLOTTING; LENS; MASS SPECTROMETRY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCANNING ELECTRON MICROSCOPY; ANIMAL; C57BL MOUSE; CATARACT; COMPARATIVE STUDY; GENOTYPE; IMPEDANCE; METABOLISM; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; ULTRASTRUCTURE;

ANIMALS; CATARACT; CYTOSKELETAL PROTEINS; CYTOSKELETON; ELECTRIC IMPEDANCE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; EYE PROTEINS; GENOTYPE; LENS, CRYSTALLINE; MASS SPECTROMETRY; MEMBRANE GLYCOPROTEINS; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, SCANNING; PHENOTYPE; PROTEOME;

EID: 84863837195     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.11-7724     Document Type: Article

References (41)

1. Van Itallie CM, Anderson JM. Claudins and epithelial paracellular transport. Annu Rev Physiol. 2006;68:403-429.
2. Ervin LA, Ball LE, Crouch RK, Schey KL. Phosphorylation and glycosylation of bovine lens MP20. Invest Ophthalmol Vis Sci. 2005;46:627-635.
3. Bassnett S, Wilmarth PA, David LL. The membrane proteome of the mouse lens fiber cell. Mol Vis. 2009;15:2448-2463.
4. Lattin JE, Schroder K, Su AI, et al. Expression analysis of G proteincoupled receptors in mouse macrophages. Immunome Res. 2008;4:5.
5. Vihtelic TS, Fadool JM, Gao J, Thornton KA, Hyde DR, Wistow G. Expressed sequence tag analysis of zebrafish eye tissues for NEIBank. Mol Vis. 2005;11:1083-1100.
6. Shiels A, Bennett TM, Hejtmancik JF. Cat-Map: putting cataract on the map. Mol Vis. 2010;16:2007-2015.
7. Steele EC Jr, Kerscher S, Lyon MF, et al. Identification of a mutation in the MP19 gene, Lim2, in the cataractous mouse mutant To3. Mol Vis. 1997;3:5.
8. Steele EC Jr, Wang JH, Lo WK, Saperstein DA, Li X, Church RL. Lim2(To3) transgenic mice establish a causative relationship between the mutation identified in the lim2 gene and cataractogenesis in the To3 mouse mutant. Mol Vis. 2000;6:85-94.
9. Puk O, Ahmad N, Wagner S, Hrabe de Angelis M, Graw J. Microphakia and congenital cataract formation in a novel Lim2 mutant mouse. Mol Vis. 2011;17:1164-1171.
10. Ponnam SP, Ramesha K, Tejwani S, Matalia J, Kannabiran C. A missense mutation in LIM2 causes autosomal recessive congenital cataract. Mol Vis. 2008;14:1204-1208.
11. Pras E, Levy-Nissenbaum E, Bakhan T, et al. A missense mutation in the LIM2 gene is associated with autosomal recessive presenile cataract in an inbred Iraqi Jewish family. Am J Hum Genet. 2002;70:1363-1367.
12. Shiels A, King JM, Mackay DS, Bassnett S. Refractive defects and cataracts in mice lacking lens intrinsic membrane protein-2. Invest Ophthalmol Vis Sci. 2007;48:500-508.
13. Shi Y, Barton K, De Maria A, Petrash JM, Shiels A, Bassnett S. The stratified syncytium of the vertebrate lens. J Cell Sci. 2009;122: 1607-1615.
14. Grey AC, Jacobs MD, Gonen T, Kistler J, Donaldson PJ. Insertion of MP20 into lens fibre cell plasma membranes correlates with the formation of an extracellular diffusion barrier. Exp Eye Res. 2003;77:567-574.
15. Shestopalov VI, Bassnett S. Expression of autofluorescent proteins reveals a novel protein permeable pathway between cells in the lens core. J Cell Sci. 2000;113:1913-1921.
16. Shestopalov VI, Bassnett S. Development of a macromolecular diffusion pathway in the lens. J Cell Sci. 2003;116:4191-4199.
17. Duncan G. The site of the ion restricting membranes in the toad lens. Exp Eye Res. 1969;8:406-412.
18. Mathias RT, White TW, Gong X. Lens gap junctions in growth, differentiation, and homeostasis. Physiol Rev. 2010;90:179-206.
19. Simirskii VN, Lee RS, Wawrousek EF, Duncan MK. Inbred FVB/N mice are mutant at the cp49/Bfsp2 locus and lack beaded filament proteins in the lens. Invest Ophthalmol Vis Sci. 2006;47:4931-4934.
20. Sandilands A, Wang X, Hutcheson AM, et al. Bfsp2 mutation found in mouse 129 strains causes the loss of CP49 and induces vimentin-dependent changes in the lens fibre cell cytoskeleton. Exp Eye Res. 2004;78:875-889.
21. De Maria A, Shi Y, Luo X, Van Der Weyden L, Bassnett S. Cadm1 expression and function in the mouse lens. Invest Ophthalmol Vis Sci. 2011;52:2293-2299.
22. Bassnett S, Shi Y, Vrensen GFJM. Biological glass: structural determinants of eye lens transparency (review). Phil Trans R Soc Lond B Biol Sci. 2011;366:1250-1264.
23. Blankenship T, Bradshaw L, Shibata B, Fitzgerald P. Structural specializations emerging late in mouse lens fiber cell differentiation. Invest Ophthalmol Vis Sci. 2007;48:3269-3276.
24. Baldo GJ, Gong X, Martinez-Wittinghan FJ, Kumar NM, Gilula NB, Mathias RT. Gap junctional coupling in lenses from alpha(8) connexin knockout mice. J Gen Physiol. 2001;118:447-456.
25. Baldo GJ, Mathias RT. Spatial variations in membrane properties in the intact rat lens. Biophys J. 1992;63:518-529.
26. Martinez-Wittinghan FJ, Sellitto C, White TW, Mathias RT, Paul D, Goodenough DA. Lens gap junctional coupling is modulated by connexin identity and the locus of gene expression. Invest Ophthalmol Vis Sci. 2004;45:3629-3637.
27. Su SP, McArthur JD, Truscott RJ, Aquilina JA. Truncation, crosslinking and interaction of crystallins and intermediate filament proteins in the aging human lens. Biochim Biophys Acta. 2011; 1814;647-656.
28. De Maria A, Shi Y, Kumar NM, Bassnett S. Calpain expression and activity during lens fiber cell differentiation. J Biol Chem. 2009;284:13542-13550.
29. Gong X, Li E, Klier G, et al. Disruption of alpha3 connexin gene leads to proteolysis and cataractogenesis in mice. Cell. 1997;91: 833-843.
30. White TW, Goodenough DA, Paul DL. Targeted ablation of connexin50 in mice results in microphthalmia and zonular pulverulent cataracts. J Cell Biol. 1998;143:815-825.
31. Shiels A, Bassnett S, Varadaraj K, et al. Optical dysfunction of the crystalline lens in aquaporin-0-deficient mice. Physiol Genomics. 2001;7:179-186.
32. Pontoriero GF, Smith AN, Miller LA, Radice GL, West-Mays JA, Lang RA. Co-operative roles for E-cadherin and N-cadherin during lens vesicle separation and lens epithelial cell survival. Dev Biol. 2009;326:403-417.
33. Kuwabara T. Microtubules in the lens. Arch Ophthalmol. 1968;79: 189-195.
34. Lee A, Morrow JS, Fowler VM. Caspase remodeling of the spectrin membrane skeleton during lens development and aging. J Biol Chem. 2001;276:20735-20742.
35. Azuma M, Fukiage C, David LL, Shearer TR. Activation of calpain in lens: a review and proposed mechanism. Exp Eye Res. 1997;64: 529-538.
36. Tang Y, Liu X, Zoltoski RK, et al. Age-related cataracts in alpha3Cx46-knockout mice are dependent on a calpain 3 isoform. Invest Ophthalmol Vis Sci. 2007;48:2685-2694.
37. Gao J, Sun X, Martinez-Wittinghan FJ, Gong X, White TW, Mathias RT. Connections between connexins, calcium, and cataracts in the lens. J Gen Physiol. 2004;124:289-300.
38. Kuszak JR, Macsai MS, Bloom KJ, Rae JL, Weinstein RS. Cell-to-cell fusion of lens fiber cells in situ: correlative light, scanning electron microscopic, and freeze-fracture studies. J Ultrastruct Res. 1985;93:144-160.
39. Mathias RT, Rae JL. Cell to cell communication in the lens. In: Sperelakis N, Cole W, eds. Cell Interactions and Gap Junctions. Boca Raton, FL: CRC; 1989:29-50.
40. Cheng C, Xia CH, Li L, White TW, Niimi J, Gong X. Gap junction communication influences intercellular protein distribution in the lens. Exp Eye Res. 2008;86:966-974.
41. Shi Y, Bassnett S. Inducible gene expression in the lens using tamoxifen and a GFP reporter. Exp Eye Res. 2007;85:732-737.