Normal early pregnancy: A transient state of epigenetic change favoring hypomethylation

Epigenetics

Volumn 7, Issue 7, 2012, Pages 729-734

  White, Wendy M ^a   Brost, Brian C ^a   Sun, Zhifu ^a   Rose, Carl ^a   Craici, Iasmina ^a   Wagner, Steven J ^a   Turner, Stephen ^a   Garovic, Vesna D ^a  

^a Mayo Clinic   (United States)

Author keywords

DNA methylation; Epigenetics; Immune; Leukocyte; Maternal; Postpartum; Pregnancy

Indexed keywords

CYTOSINE; GUANINE;

ADULT; ARTICLE; BODY MASS; CONTROLLED STUDY; DNA METHYLATION; EPIGENETICS; FEMALE; FIRST TRIMESTER PREGNANCY; GENETIC ASSOCIATION; GESTATION PERIOD; HUMAN; NORMAL HUMAN; PUERPERIUM;

EID: 84863809548     PISSN: 15592294     EISSN: 15592308     Source Type: Journal    
DOI: 10.4161/epi.20388     Document Type: Article

References (33)

1. Bird A. Perceptions of epigenetics. Nature 2007; 447:396-398. PMID:17522671; http://dx.doi.org/10.1038/nature05913.
2. Richards EJ. Inherited epigenetic variation-revisiting soft inheritance. Nat Rev Genet 2006; 7:395-401. PMID:16534512; http://dx.doi.org/10.1038/nrg1834.
3. Suzuki MM, Bird A. DNA methylation landscapes: provocative insights from epigenomics. Nat Rev Genet 2008; 9:465-476. PMID:18463664; http://dx.doi.org/10.1038/nrg2341.
4. Tost J. DNA methylation: an introduction to the biology and the disease-associated changes of a promising biomarker. Mol Biotechnol 2010; 44:71-81. PMID:19842073; http://dx.doi.org/10.1007/s12033-009-9216-2.
5. Feinberg AP. Genome-scale approaches to the epigenetics of common human disease. Virchows Arch 2010; 456:13-21. PMID:19844740; http://dx.doi.org/10.1007/s00428-009-0847-2.
6. Sun Z, Chai HS, Wu Y, White WM, Donkena KV, Klein CJ, et al. Batch effect correction for genome-wide methylation data with Illumina Infinium platform. BMC Med Genomics 2011; 4:84. PMID:22171553; http://dx.doi.org/10.1186/1755-8794-4-84.
7. GeneCards (Internet). Rehovet: Weizmann Institute of Science 1996 2012. www.genecards.org.
8. Librach CL, Feigenbaum SL, Bass KE, Cui TY, Verastas N, Sadovsky Y, et al. Interleukin-1beta regulates human cytotrophoblast metalloproteinase activity and invasion in vitro. J Biol Chem 1994; 269:17125-17131. PMID:8006017.
9. Herrmann-Lavoie C, Rao CV, Akoum A. Chorionic gonadotropin downregulates the expression of the decoy inhibitory interleukin 1 receptor type II in human endometrial epithelial cells. Endocrinology 2007; 148:5377-5384. PMID:17702847; http://dx.doi.org/10.1210/en.2007-0368.
10. Chow SS, Craig ME, Jones CA, Hall B, Catteau J, Lloyd AR, et al. Differences in amniotic fluid and maternal serum cytokine levels in early midtrimester women without evidence of infection. Cytokine 2008; 44:78-84. PMID:18703348; http://dx.doi.org/10.1016/j.cyto.2008.06.009.
11. Product Information and Manual: Human IL-1B High Sensitivity ELISA BMS224HS. Vienna: eBioscience 2010.
12. Kuhajda FP, Piantadosi S, Pasternack GR. Haptoglobinrelated protein (Hpr) epitopes in breast cancer as a predictor of recurrence of the disease. N Engl J Med 1989; 321:636-641. PMID:2475778; http://dx.doi.org/10.1056/NEJM198909073211003.
13. Kuhajda FP, Katumuluwa AI, Pasternack GR. Expression of haptoglobin-related protein and its potential role as a tumor antigen. Proc Natl Acad Sci USA 1989; 86:1188-1192. PMID:2465547; http://dx.doi.org/10.1073/pnas.86.4.1188.
14. Hoffman LH, Winfrey VP, Blaeuer GL, Olson GE. A haptoglobin-like glycoprotein is produced by implantation-stage rabbit endometrium. Biol Reprod 1996; 55:176-184. PMID:8793073; http://dx.doi.org/10.1095/biolreprod55.1.176.
15. Avila L, Yuen RK, Diego-Alvarez D, Peñaherrera MS, Jiang R, Robinson WP. Evaluating DNA methylation and gene expression variability in the human term placenta. Placenta 2010; 31:1070-1077. PMID:20947161; http://dx.doi.org/10.1016/j.placenta.2010.09.011.
16. Bellido ML, Radpour R, Lapaire O, De Bie I, Hösli I, Bitzer J, et al. MALDI-TOF mass array analysis of RASSF1A and SERPINB5 methylation patterns in human placenta and plasma. Biol Reprod 2010; 82:745-750. PMID:20075396; http://dx.doi.org/10.1095/biolreprod.109.082271.
17. Bourque DK, Avila L, Peñaherrera M, von Dadelszen P, Robinson WP. Decreased placental methylation at the H19/IGF2 imprinting control region is associated with normotensive intrauterine growth restriction but not preeclampsia. Placenta 2010; 31:197-202. PMID:20060582; http://dx.doi.org/10.1016/j.placenta.2009.12.003.
18. Chiu RW, Chim SS, Wong IH, Wong CS, Lee WS, To KF, et al. Hypermethylation of RASSF1A in human and rhesus placentas. Am J Pathol 2007; 170:941-950. PMID:17322379; http://dx.doi.org/10.2353/ajpath.2007.060641.
19. Zhao A, Cheng Y, Li X, Li Q, Wang L, Xu J, et al. Promoter hypomethylation of COMT in human placenta is not associated with the development of pre-eclampsia. Mol Hum Reprod 2011; 17:199-206. PMID:21047975; http://dx.doi.org/10.1093/molehr/gaq092.
20. Yuen RK, Avila L, Peñaherrera MS, von Dadelszen P, Lefebvre L, Kobor MS, et al. Human placentalspecific epipolymorphism and its association with adverse pregnancy outcomes. PLoS One 2009; 4:7389. PMID:19838307; http://dx.doi.org/10.1371/journal.pone.0007389.
21. Yuen RK, Peñaherrera MS, von Dadelszen P, McFadden DE, Robinson WP. DNA methylation profiling of human placentas reveals promoter hypomethylation of multiple genes in early-onset preeclampsia. Eur J Hum Genet 2010; 18:1006-1012. PMID:20442742; http://dx.doi.org/10.1038/ejhg.2010.63.
22. Kulkarni A, Chavan-Gautam P, Mehendale S, Yadav H, Joshi S. Global DNA methylation patterns in placenta and its association with maternal hypertension in pre-eclampsia. DNA Cell Biol 2011; 30:79-84. PMID:21043832; http://dx.doi.org/10.1089/dna.2010.1084.
23. Katari S, Turan N, Bibikova M, Erinle O, Chalian R, Foster M, et al. DNA methylation and gene expression differences in children conceived in vitro or in vivo. Hum Mol Genet 2009; 18:3769-3778. PMID:19605411; http://dx.doi.org/10.1093/hmg/ddp319.
24. Bouchard L, Thibault S, Guay SP, Santure M, Monpetit A, St-Pierre J, et al. Leptin gene epigenetic adaptation to impaired glucose metabolism during pregnancy. Diabetes Care 2010; 33:2436-2441. PMID:20724651; http://dx.doi.org/10.2337/dc10-1024.
25. Müller HM, Ivarsson L, Schröcksnadel H, Fiegl H, Widschwendter A, Goebel G, et al. DNA methylation changes in sera of women in early pregnancy are similar to those in advanced breast cancer patients. Clin Chem 2004; 50:1065-1068. PMID:15161724; http://dx.doi.org/10.1373/clinchem.2003.030387.
26. Veenstra van Nieuwenhoven AL, Heineman MJ, Faas MM. The immunology of successful pregnancy. Hum Reprod Update 2003; 9:347-357. PMID:12926528; http://dx.doi.org/10.1093/humupd/dmg026.
27. Mor G, Cardenas I. The immune system in pregnancy: a unique complexity. Am J Reprod Immunol 2010; 63:425-433. PMID:20367629; http://dx.doi.org/10.1111/j.1600-0897.2010.00836.x.
28. Ioannidis JP, Thomas G, Daly MJ. Validating, augmenting and refining genome-wide association signals. Nat Rev Genet 2009; 10:318-329. PMID:19373277;http://dx.doi.org/10.1038/nrg2544.
29. Liu YJ, Papa sian CJ, Liu JF, Hamilton J, Deng HW. Is replication the gold standard for validating genomewide association findings? PLoS One 2008; 3:4037. PMID:19112512; http://dx.doi.org/10.1371/journal.pone.0004037.
30. Rakyan VK, Down TA, Balding DJ, Beck S. Epigenome-wide association studies for common human diseases. Nat Rev Genet 2011; 12:529-541. PMID:21747404; http://dx.doi.org/10.1038/nrg3000.
31. Teschendorff AE, Menon U, Gentry-Maharaj A, Ramus SJ, Weisenberger DJ, Shen H, et al. Agedependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer. Genome Res 2010; 20:440-446. PMID:20219944; http://dx.doi.org/10.1101/gr.103606.109.
32. Bell CG, Teschendorff AE, Rakyan VK, Maxwell AP, Beck S, Savage DA. Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus. BMC Med Genomics 2010; 3:33. PMID:20687937; http://dx.doi.org/10.1186/1755-8794-3-33.
33. Storey JD, Tibshirani R. Statistical methods for identifying differentially expressed genes in DNA microarrays. Methods Mol Biol 2003; 224:149-157. PMID:12710672.