Downregulation of ferroportin 1 expression in hFOB1.19 osteoblasts by hepcidin

Inflammation

Volumn 35, Issue 3, 2012, Pages 1058-1061

  Xu, Youjia ^a   Zhang, Wei ^a   Zhang, Peng ^a   Xiao, Li ^a   Wang, Aidong ^a   Sirois, Pierre ^b   Li, Kai ^a  

^a SOOCHOW UNIVERSITY   (China)

^b LAVAL UNIVERSITY   (Canada)

Author keywords

Bone metabolism; Ferroportin 1; Hepcidin; Osteoblast

Indexed keywords

FERROPORTIN 1; HEPCIDIN; IRON; RNA;

ANIMAL CELL; ARTICLE; BONE METABOLISM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; INCUBATION TIME; INTESTINE CELL; IRON BALANCE; LIVER CELL; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOPOROSIS; PATHOPHYSIOLOGY; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; TARGET CELL; WESTERN BLOTTING;

ANTIMICROBIAL CATIONIC PEPTIDES; CATION TRANSPORT PROTEINS; CELL LINE; DOWN-REGULATION; ENTEROCYTES; HEPATOCYTES; HUMANS; OSTEOBLASTS; OSTEOPOROSIS;

EID: 84863799042     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-011-9411-8     Document Type: Article

References (13)

1. Weinberg, E.D. 2008. Role of iron in osteoporosis. Pediatric Endocrinology Reviews Suppl 1: 81-85.
2. Morabito, N., G.T. Russo, A. Gaudio, A. Lasco, A. Catalano, E. Morini, et al. 2007. The "lively" cytokines network in beta-thalassemia major-related osteoporosis. Bone 40: 1588-1594. (Pubitemid 46766649)
3. Park, C.H., E.V. Valore, A.J. Waring, and T. Ganz. 2001. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. Journal of Biological Chemistry 276: 7806-7810.
4. Fleming, R.E., and W.S. Sly. 2002. Mechanisms of iron accumulation in hereditary hemochromatosis. Annual Review of Physiology 64: 663-680. (Pubitemid 34259245)
5. Maliken, B.D., J.E. Nelson, and K.V. Kowdley. 2011. The hepcidin circuits act: balancing iron and inflammation. Hepatology 53: 1764-1766.
6. Kwaan, H.C. 2011. Infection and anemia. Infectious Disorders Drug Targets 11: 40-44.
7. Steinbicker, A.U., C. Sachidanandan, A.J. Vonner, R.Z. Yusuf, D.Y. Deng, C.S. Lai, et al. 2011. Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation. Blood 117: 4915-4923.
8. Ge, X.H., Q. Wang, Z.M. Qian, L. Zhu, F. Du, W.H. Yung, et al. 2009. The iron regulatory hormone hepcidin reduces ferroportin 1 content and iron release in H9C2 cardiomyocytes. The Journal of Nutritional Biochemistry 20: 860-865.
9. Donovan, A., C.A. Lima, J.L. Pinkus, G.S. Pinkus, L.I. Zon, S. Robine, et al. 2005. The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metabolism 1: 191-200. (Pubitemid 43960600)
10. Yamasaki, K., and H. Hagiwara. 2009. Excess iron inhibits osteoblast metabolism. Toxicology Letters 191: 211-215.
11. Ganz, T. 2006. Hepcidin and its role in regulating systemic iron metabolism. Hematology 507: 29-35.
12. Zhang, P., Y.J. Xu, D.Y. Zhao, B. Wang, Y. Ma, Z.M. Qian, et al. 2008. Influence of hepcidin and iron ion out of osteoblast on calcium transportation. Chinese Journal of Osteoporosis 14: 504-507.
13. Zhao, D.Y., Y.J. Xu, P. Zhang, Y.M. Hao, Y. Ma, and B. Wang. 2008. A study on the influence of hepcidin out of osteoblasts on iron transportation. Chinese Journal of Osteoporosis 14: 611-614.