Upregulation of the vascular endothelial growth factor, Flt-1, in rat hippocampal neurons after envenoming by Phoneutria nigriventer; age-related modulation

Toxicon

Volumn 60, Issue 4, 2012, Pages 656-664

  Mendonça, Monique Culturato Padilha ^a   Siqueira Soares, Edilene ^a   Miguel Stávale, Leila ^a   Pierre Irazusta, Silvia ^b   da Cruz Höfling, Maria Alice ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b Faculdade de Tecnologia de Sorocaba   (Brazil)

Author keywords

Blood brain barrier; GIMP; Image processing; Spider venom; VEGF

Indexed keywords

SODIUM CHLORIDE; SPIDER VENOM; VASCULOTROPIN RECEPTOR 1;

AGE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARMED SPIDER; ARTICLE; BLOOD BRAIN BARRIER; BRAIN EDEMA; BRAIN NERVE CELL; CONTROLLED STUDY; DENTATE GYRUS; ENVENOMATION; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA2 REGION; HIPPOCAMPAL CA3 REGION; HIPPOCAMPUS; MALE; NEUROMODULATION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; SPIDER; UPREGULATION;

AGE FACTORS; ANIMALS; BIOLOGICAL MARKERS; BLOOD-BRAIN BARRIER; BRAIN EDEMA; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HIPPOCAMPUS; IMAGE PROCESSING, COMPUTER-ASSISTED; MALE; NEURONS; PERMEABILITY; RATS; RATS, WISTAR; SPIDER VENOMS; SPIDERS; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1;

ANIMALIA; ARANEAE; PHONEUTRIA NIGRIVENTER; RATTUS;

EID: 84863784696     PISSN: 00410101     EISSN: 18793150     Source Type: Journal    
DOI: 10.1016/j.toxicon.2012.05.015     Document Type: Article

References (28)

1. Altman J., Das G.D. Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J. Comp. Neurol. 1965, 124:319-335.
2. Brockington A., Lewist C., Wharton S., Shaw P.J. Vascular endothelial growth factor and the nervous system. Neuropathol. Appl. Neurobiol. 2004, 30:427-446.
3. Bucaretchi F., Reinaldo C.R.D., Hyslop S., Madureira P.R., de Capitani E.M., Vieira R.J. A clinico-epidemiological study of bites by spiders of the genus Phoneutria. Rev. Inst. Med. Trop. São Paulo 2000, 42:17-21.
4. Cameron H.A., Woolley C.S., McEwen B.S., Gould E. Differentiation of newly born neurons and glia in the dentate gyrus of the adult rat. Neuroscience 1993, 56:337-344.
5. Choi J.S., Kim H.Y., Cha J.H., Choi J.Y., Chun M.H., Lee M.Y. Upregulation of vascular endothelial growth factor receptors Flt-1 and Flk-1 in rat hippocampus after transient forebrain ischemia. J. Neurotrauma 2007, 24:521-531.
6. da Cruz-Höfling M.A., Zago G.M., Melo L.L., Raposo C. c-FOS and n-NOS reactive neurons in response to circulating Phoneutria nigriventer spider venom. Brain Res. Bull. 2007, 73:114-126.
7. da Cruz-Höfling M.A., Raposo C., Verinaud L., Zago G.M. Neuroinflammation and astrocytic reaction in the course of Phoneutria nigriventer (armed-spider) blood-brain barrier (BBB) opening. Neurotoxicology 2009, 30:636-646.
8. Dhondt J., Peeraer E., Verheyen A., Nuydens R., Buysschaert I., Poesen K., Van Geyte K., Beerens M., Shibuya M., Haigh J.J., Meert T., Carmeliet P., Lambrechts D. Neuronal FLT1 receptor and its selective ligand VEGF-B protect against retrograde degeneration of sensory neurons. FASEB J. 2011, 25:1461-1473.
9. Dourado D.M., Fávero S., Matias R., Carvalho P.T.C., da Cruz-Höfling M.A. Low-level laser therapy promotes vascular endothelial growth factor receptor-1 expression in endothelial and nonendothelial cells of mice gastrocnemius exposed to snake venom. Photochem. Photobiol. 2011, 87:418-426.
10. Feistritzer C., Mosheimer B.A., Sturn D.H., Bijuklic K., Patsch J.R., Wiedermman C.J. Expression and function of the angiopoietin receptor Tie-2 in human eosinophils. J. Allergy Clin. Immunol. 2004, 114(5):1077-1084.
11. Forstreuter F., Lucius R., Mentlein R. Vascular endothelial growth factor induces chemotaxis and proliferation of microglial cells. J. Neuroimmunol. 2002, 132:93-98.
12. Gomez M.V., Kalapothakis E., Guatimosim C., Prado M.A. Phoneutria nigriventer venom: a cocktail of toxins that affect ion channels. Cell. Mol. Neurobiol. 2002, 22:579-588.
13. Hansen T.M., Moss A.J., Brindle N.P. Vascular endothelial growth factor and angiopoietins in neurovascular regeneration and protection following stroke. Curr. Neurovasc. Res. 2008, 5:236-245.
14. Hoshino M., Takahashi M., Aoike N. Expression of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin immunoreactivity in asthmatic airways and its relationship to angiogenesis. J. Allergy Clin. Immunol. 2001, 107:295-301.
15. Islamov R.R., Chintalgattu V., Pak E.S., Katwa L.C., Murashov A.K. Induction of VEGF and its Flt-1 receptor after sciatic nerve crush injury. Neuroreport 2004, 15:713-717.
16. Klausberger T., Somogyi P. Neuronal diversity and temporal dynamics: the unity of hippocampal circuit operations. Science 2008, 321:53-57.
17. Le Sueur L., Kalapothakis E., da Cruz-Höfling M.A. Breakdown of the blood-brain barrier and neuropathological changes induced by Phoneutria nigriventer spider venom. Acta Neuropathol. (Berl) 2003, 105:125-134.
18. Levison S.W., Goldman J.E. Both oligodendrocytes and astrocytes develop from progenitors in the subventricular zone of postnatal rat forebrain. Neuron 1993, 10:201-212.
19. Luskin M.B. Restricted proliferation and migration of post natally generated neurons derived from the forebrain subventricular zone. Neuron 1993, 11:173-189.
20. Olsson A.K., Dimberg A., Kreuger J., Claesson-Welsh L. VEGF receptor signaling in control of vascular function. Nat. Rev. Mol. Cell Biol. 2006, 7:359-371.
21. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates 1998, Academic Press, San Diego, CA.
22. Poesen K., Lambrechts D., Van Damme P., Dhondt J., Bender F., Frank N., Bogaert E., Claes B., Heylen L., Verheyen A., Raes K., Tjwa M., Eriksson U., Shibuya M., Nuydens R., Van Den Bosch L., Meert T., D'Hooge R., Sendtner M., Robberecht W., Carmeliet P. Novel role for vascular endothelial growth factor (VEGF) receptor-1 and its ligand VEGF-B in motor neuron degeneration. J. Neurosci. 2008, 28:10451-10459.
23. Rapôso C., Zago G.M., Silva G.H., da Cruz-Höfling M.A. Acute blood-brain barrier permeabilization in rats after systemic Phoneutria nigriventer venom. Brain Res. 2007, 1149:18-29.
24. Ryu J.K., Cho T., Choi H.B., Wang Y.T., McLarnon J.G. Microglial VEGF receptor response is an integral chemotactic component in Alzheimer's disease pathology. J. Neurosci. 2009, 29:3-13.
25. Ruiz de Almodovar C., Lambrechts D., Mazzone M., Carmeliet P. Role and therapeutic potential of VEGF in the nervous system. Physiol. Rev. 2009, 89:607-648.
26. Saab B.J., Georgiou J., Nath A., Lee F.J., Wang M., Michalon A., Liu F., Mansuy I.M., Roder J.C. NCS-1 in the dentate gyrus promotes exploration, synaptic plasticity, and rapid acquisition of spatial memory. Neuron 2009, 63:643-656.
27. Shibuya M., Claesson-Welsh L. Signal transduction by VEGF receptors in regulation of angiogenesis and lymph angiogenesis. Exp. Cell Res. 2006, 312:549-560.
28. Solomon R.W. Free and open source software for manipulation of digital images. AJR Am. J. Roentgenol. 2009, 192:w330-334.