Diagnosis of PFAPA syndrome applied to a cohort of 17 adults with unexplained recurrent fevers

Clinical and Experimental Rheumatology

Volumn 30, Issue 2, 2012, Pages 269-271

  Cantarini, Luca ^a   Vitale, Antonio ^a   Bartolomei, Beatrice ^b   Galeazzi, Mauro ^a   Rigante, Donato ^b  

^a UNIVERSITY HOSPITAL OF SIENA   (Italy)

^b FONDAZIONE POLICLINICO UNIVERSITARIO A GEMELLI IRCCS   (Italy)

Author keywords

Corticosteroids; PFAPA syndrome; Recurrent fever; Tonsillectomy

Indexed keywords

AMYLOID A PROTEIN; C REACTIVE PROTEIN; COLCHICINE; IBUPROFEN; IMMUNOGLOBULIN D; INDOMETACIN; NAPROXEN; PARACETAMOL; PREDNISOLONE; PREDNISONE;

ABDOMINAL PAIN; ADULT; ARTHRALGIA; ARTICLE; ASTHENIA; CLINICAL ARTICLE; CLINICAL FEATURE; DISEASE DURATION; DRUG EFFICACY; DRUG RESPONSE; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; FEVER; FOLLICULITIS; GENE MUTATION; HEADACHE; HUMAN; LEUKOCYTE COUNT; MALE; MYALGIA; ONSET AGE; OUTCOME ASSESSMENT; PFAPA SYNDROME; PRIORITY JOURNAL; RASH; RECURRENT FEVER; RETROSPECTIVE STUDY; TONSILLECTOMY;

ADRENAL CORTEX HORMONES; ADULT; FEMALE; FEVER; HUMANS; ITALY; LYMPHADENITIS; MALE; PHARYNGITIS; RETROSPECTIVE STUDIES; STOMATITIS, APHTHOUS; SYNDROME; TIME FACTORS; TONSILLECTOMY; TREATMENT OUTCOME;

EID: 84863768624     PISSN: 0392856X     EISSN: 1593098X     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. MARSHALL GS, EDWARDS KM, BUTLER J, LAWTON AR. Syndrome of periodic fever, pharyngitis, and aphthous stomatitis. J Pediatr 1987; 110: 43-6.
2. TASHER D, SOMEKH E, DALAL I. PFAPA syndrome: new clinical aspects disclosed. Arch Dis Child 2006; 91: 981-4.
3. RIGANTE D. Autoinflammatory syndromes in children. J Pediatr Sci 2010; 4: e56.
4. LONG S. Syndrome of Periodic Fever, Aphtous stomatitis, Pharyngitis and Adenitis (PFAPA)- What it isn't. What is it? J Pediatr 1999; 135: 1-5.
5. THOMAS KT, FEDER HM, LAWTON AR, EDWARDS KM. Periodic fever syndrome in children. J Pediatr 1999; 135: 15-21.
6. PADEH S. Periodic fever, aphtous stomatitis, pharyngitis, and adenopathy syndrome: Clinical characteristics and outcome. J Pediatr 1999; 135: 98-101.
7. RENKO M, SALO E, PUTTO-LAURILA A et al. A randomized, controlled trial of tonsillectomy in Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Adenitis Syndrome. J Pediatr 2007; 151: 289-92.
8. FEDER HM, SALAZAR JC. A clinical review of 105 patients with PFAPA (a periodic fever syndrome). Acta Paediatr 2010; 99: 178-84.
9. BROWN KL, WEKELL P, OSLA V et al. Profile of blood cells and inflammatory mediators in periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome. BMC Pediatr 2010 Sep 6; 10: 65.
10. STOJANOV S, LAPIDUS S, CHITKARA P et al. Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) is a disorder of innate immunity and Th1 activation responsive to IL-1 blockade. Proc Natl Acad Sci USA 2011; 108: 7148-53.
11. CANTARINI L, LUCHERINI OM, IACOPONI F et al. Development and preliminary validation of a diagnostic score for identifying patients affected with adult-onset autoinflammatory disorders. Int J Immunopathol Pharmacol 2010; 23: 1133-41.
12. CAVUOTO M, BONAGURA VR. Adult-onset periodic fever, aphthous stomatitis, pharyngitis, and adenitis. Ann Allergy Asthma Immunol 2008; 100: 170.
13. PADEH S, STOFFMAN N, BERKUN Y. Periodic fever accompanied by aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA syndrome) in adults. Isr Med Assoc J 2008; 10: 358-60.
14. CAZZATO M, NERI R, POSSEMATO N, PUCCINI R, BOMBARDIERI S. A case of adult periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome associated with endocapillary proliferative glomerulonephritis. Clin Rheumatol 2010 Mar 12 [Epub].
15. COLOTTO M, MARANGHI M, DURANTE C, ROSSETTI M, RENZI A, ANATRA MG. PFAPA syndrome in a young adult with a history of tonsillectomy. Intern Med 2011; 50: 223-5.