Chlorhexidine gluconate reduces transmission of methicillin-resistant Staphylococcus aureus USA300 among marine recruits

Infection Control and Hospital Epidemiology

Volumn 33, Issue 8, 2012, Pages 809-816

  Whitman, Timothy J ^a   Schlett, Carey D ^b   Grandits, Greg A ^c   Millar, Eugene V ^b   Mende, Katrin ^b,d   Hospenthal, Duane R ^d   Murray, Patrick R ^e   Tribble, David R ^b  

^a WALTER REED ARMY MEDICAL CENTER   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

^d SAN ANTONIO MILITARY MEDICAL CENTER   (United States)

^e NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORHEXIDINE GLUCONATE;

ARTICLE; BACTERIAL COLONIZATION; BACTERIAL STRAIN; BACTERIUM ISOLATE; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DISEASE TRANSMISSION; DOUBLE BLIND PROCEDURE; DRUG SCREENING; FOLLOW UP; GEL ELECTROPHORESIS; HUMAN; INFECTION CONTROL; MAJOR CLINICAL STUDY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL;

ANTI-INFECTIVE AGENTS, LOCAL; AXILLA; CARRIER STATE; CHLORHEXIDINE; COMMUNITY-ACQUIRED INFECTIONS; DNA, BACTERIAL; ELECTROPHORESIS, GEL, PULSED-FIELD; HUMANS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MILITARY PERSONNEL; MOLECULAR EPIDEMIOLOGY; MOLECULAR TYPING; NOSE; STAPHYLOCOCCAL INFECTIONS; UNITED STATES;

EID: 84863749667     PISSN: 0899823X     EISSN: None     Source Type: Journal    
DOI: 10.1086/666631     Document Type: Article

References (35)

1. Ellis MW, Hospenthal DR, Dooley DP, Gray PJ, Murray CK. Natural history of community-acquired methicillin-resistant Staphylococcus aureus colonization and infection in soldiers. Clin Infect Dis 2004;39(7):971-979.
2. Fridkin SK, Hageman JC, Morrison M, et al. Methicillin-resis-tant Staphylococcus aureus disease in three communities. N Engl J Med 2005;352(14):1436-1444.
3. Kravitz GR, Dries DJ, Peterson ML, Schlievert PM. Purpura fulminans due to Staphylococcus aureus. Clin Infect Dis 2005; 40(7):941-947.
4. Gorwitz RJ, Jernigan DB, Powers JH, Jernigan JA, Participants in the CDC Convened Experts' Meeting on Management of MRSA in the Community. Strategies for Clinical Management of MRSA in the Community: Summary of an Experts' Meeting Convened by the Centers for Disease Control and Prevention. Centers for Disease Control and Prevention, 2006. http://www.cdc.gov/ncidod/dhqp/ar_mrsa_ca.html.
5. Whitman TJ, Herlihy RK, Schlett CD, et al. Chlorhexidine-impregnated cloths to prevent skin and soft-tissue infection in Marine recruits: a cluster-randomized, double-blind, controlled effectiveness trial. Infect Control Hosp Epidemiol 2010;31(12): 1207-1215.
6. McDougal LK, Steward CD, Killgore GE, Chaitram JM, McAllister SK, Tenover FC. Pulsed-field gel electrophoresis typing of oxacillin-resistant Staphylococcus aureus isolates from the United States: establishing a national database. J Clin Microbiol 2003;41(11):5113-5120.
7. Gorwitz RJ, Kruszon-Moran D, McAllister SK, et al. Changes in the prevalence of nasal colonization with Staphylococcus au-reus in the United States, 2001-2004. J Infect Dis 2008;197(9): 1226-1234.
8. Tenover FC, McAllister S, Fosheim G, et al. Characterization of Staphylococcus aureus isolates from nasal cultures collected from individuals in the United States in 2001 to 2004. J Clin Microbiol 2008;46(9):2837-2841.
9. Blanc DS, Petignat C, Wenger A, et al. Changing molecular epidemiology of methicillin-resistant Staphylococcus aureus in a small geographic area over an eight-year period. J Clin Microbiol 2007;45(11):3729-3736.
10. King MD, Humphrey BJ, Wang YF, Kourbatova EV, Ray SM, Blumberg HM. Emergence of community-acquired methicillin-resistant Staphylococcus aureus USA 300 clone as the predominant cause of skin and soft-tissue infections. Ann Intern Med 2006;144(5):309-317.
11. Ellis MW, Griffith ME, Jorgensen JH, Hospenthal DR, Mende K, Patterson JE. Presence and molecular epidemiology of virulence factors in methicillin-resistant Staphylococcus aureus strains colonizing and infecting soldiers. J Clin Microbiol 2009; 47(4):940-945.
12. Tenover FC, Tickler IA, Goering RV, Kreiswirth BN, Mediavilla JR, Persing DH. Characterization of nasal and blood culture isolates of methicillin-resistant Staphylococcus aureus from patients in United States hospitals. Antimicrob Agents Chemother 2012;56(3):1324-1330.
13. Bannerman T. Staphylococci and other catalase-positive cocci that grow aerobically. In: Murray PR, Baron EJ, Jorgensen JH, Pfaller MA, Yolken RH, eds. Manual of Clinical Microbiology. 8th ed. Washington, DC: ASM, 2003:384-404.
14. Tenover FC, Arbeit RD, Goering RV, et al. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Mi-crobiol 1995;33(9):2233-2239.
15. Murray CK, Holmes RL, Ellis MW, et al. Twenty-five year epidemiology of invasive methicillin-resistant Staphylococcus au-reus (MRSA) isolates recovered at a burn center. Burns 2009; 35(8):1112-1117.
16. Clinical and Laboratory Standards Institute. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobi-cally: Approved Standard; Seventh Edition. Wayne, PA: CLSI; 2006. CLSI document M7-A7;26(2).
17. Cookson BD, Bolton MC, Platt JH. Chlorhexidine resistance in methicillin-resistant Staphylococcus aureus or just an elevated MIC? an in vitro and in vivo assessment. Antimicrob Agents Chemother 1991;35(10):1997-2002.
18. Noguchi N, Hase M, Kitta M, Sasatsu M, Deguchi K, Kono M. Antiseptic susceptibility and distribution of antiseptic-resistance genes in methicillin-resistant Staphylococcus aureus. FEMS Mi-crobiol Lett 1999;172(2):247-253.
19. Austin PC. A comparison of the statistical power of different methods for the analysis of cluster randomization trials with binary outcomes. Stat Med 2007;26(19):3550-3565.
20. Popovich KJ, Weinstein RA, Hota B. Are community-associated methicillin-resistant Staphylococcus aureus (MRSA) strains replacing traditional nosocomial MRSA strains? Clin Infect Dis 2008;46(6):787-794.
21. Seybold U, Kourbatova EV, Johnson JG, et al. Emergence of community-associated methicillin-resistant Staphylococcus au-reus USA300 genotype as a major cause of health care-associated blood stream infections. Clin Infect Dis 2006;42(5):647-656.
22. D'Agata EM, Webb GF, Horn MA, Moellering RC Jr, Ruan S. Modeling the invasion of community-acquired methicillin-resistant Staphylococcus aureus into hospitals. Clin Infect Dis 2009;48(3):274-284.
23. Sivaraman K, Venkataraman N, Cole AM. Staphylococcus aureus nasal carriage and its contributing factors. Future Microbiol 2009; 4(8):999-1008.
24. Diep BA, Otto M. The role of virulence determinants in community-associated MRSA pathogenesis. Trends Microbiol 2008; 16(8):361-369.
25. van Belkum A, Melles DC, Nouwen J, et al. Co-evolutionary aspects of human colonisation and infection by Staphylococcus aureus. Infect Genet Evol 2009;9(1):32-47.
26. Moran GJ, Krishnadasan A, Gorwitz RJ, et al. Methicillin-resistant S. aureus infections among patients in the emergency department. N Engl J Med 2006;355(7):666-674.
27. Milstone AM, Passaretti CL, Perl TM. Chlorhexidine: expanding the armamentarium for infection control and prevention. Clin Infect Dis 2008;46(2):274-281.
28. Bleasdale SC, Trick WE, Gonzalez IM, Lyles RD, Hayden MK, Weinstein RA. Effectiveness of chlorhexidine bathing to reduce catheter-associated bloodstream infections in medical intensive care unit patients. Arch Intern Med 2007;167(19):2073-2079.
29. Popovich KJ, Hota B, Hayes R, Weinstein RA, Hayden MK. Effectiveness of routine patient cleansing with chlorhexidine glu-conate for infection prevention in the medical intensive care unit. Infect Control Hosp Epidemiol 2009;30(10):959-963.
30. Climo MW, Sepkowitz KA, Zuccotti G, et al. The effect of daily bathing with chlorhexidine on the acquisition of methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococ-cus, and healthcare-associated bloodstream infections: results of a quasi-experimental multicenter trial. Crit Care Med 2009; 37(6):1858-1865.
31. Wendt C, Schinke S, Wurttemberger M, Oberdorfer K, Bock-Hensley O, von Baum H. Value of whole-body washing with chlorhexidine for the eradication of methicillin-resistant Staph-ylococcus aureus: a randomized, placebo-controlled, double-blind clinical trial. Infect Control Hosp Epidemiol 2007;28(9): 1036-1043.
32. Wang JT, Sheng WH, Wang JL, et al. Longitudinal analysis of chlorhexidine susceptibilities of nosocomial methicillin-resistant Staphylococcus aureus isolates at a teaching hospital in Taiwan. J Antimicrob Chemother 2008;62(3):514-517.
33. Noguchi N, Suwa J, Narui K, et al. Susceptibilities to antiseptic agents and distribution of antiseptic-resistance genes qacA/B and smr of methicillin-resistant Staphylococcus aureus isolated in Asia during 1998 and 1999. J Med Microbiol 2005;54(6):557-565.
34. Creech CB, Saye E, McKenna BD, et al. One-year surveillance of methicillin-resistant Staphylococcus aureus nasal colonization and skin and soft tissue infections in collegiate athletes. Arch Pediatr Adolesc Med 2010;164(7):615-620.
35. Yang ES, Tan J, Eells S, Rieg G, Tagudar G, Miller LG. Body site colonization in patients with community-associated methicillin-resistant Staphylococcus aureus and other types of S. aureus skin infections. Clin Microbiol Infect 2010;16(5):425-431.