Non-steroidal anti-inflammatory drugs and the risk of Clostridium difficile-associated disease

British Journal of Clinical Pharmacology

Volumn 74, Issue 2, 2012, Pages 370-375

  Suissa, Daniel ^a   Delaney, Joseph A C ^b   Dial, Sandra ^c   Brassard, Paul ^c,d  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^b UNIVERSITY OF FLORIDA HEALTH   (United States)

^c MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^d MCGILL UNIVERSITY   (Canada)

Author keywords

Clostridium difficile; Diclofenac; NSAID; Risk factor

Indexed keywords

ACETYLSALICYLIC ACID; CYCLOOXYGENASE 2 INHIBITOR; DICLOFENAC; IBUPROFEN; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT;

ADULT; ALCOHOL CONSUMPTION; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLOSTRIDIUM DIFFICILE INFECTION; CONGESTIVE HEART FAILURE; DEMENTIA; DIABETES MELLITUS; DISEASE ASSOCIATION; DIVERTICULOSIS; DOSE RESPONSE; DRUG USE; ENTERITIS; FEMALE; GASTROINTESTINAL HEMORRHAGE; GASTROINTESTINAL REFLUX; HEART INFARCTION; HUMAN; INFECTION RISK; KIDNEY FAILURE; LIVER FAILURE; MAJOR CLINICAL STUDY; MALE; NEOPLASM; PEPTIC ULCER; POPULATION BASED CASE CONTROL STUDY; PRIORITY JOURNAL; STROKE; UNITED KINGDOM;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CASE-CONTROL STUDIES; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM INFECTIONS; DICLOFENAC; GENERAL PRACTICE; GREAT BRITAIN; HUMANS; LOGISTIC MODELS; ODDS RATIO; RISK ASSESSMENT; RISK FACTORS; TIME FACTORS;

EID: 84863742189     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2012.04191.x     Document Type: Article

References (17)

1. Kyne L, Hamel MB, Polavaram R, Kelly CP. Health care costs and mortality associated with nosocomial diarrhea due to Clostridium difficile. Clin Inf Dis 2002; 34: 346-53.
2. Dial S, Delaney JA, Barkun AN, Suissa S. Use of gastric acid-suppressive agents and the risk of community-acquired Clostridium. J Am Med Assoc 2005; 294: 2989-95.
3. Kyne L, Merry CO, Keane C, O'Neil D, Connel B. Community-acquired Clostridium difficile infection. J Inf 1998; 17: 287-8.
4. Karlstrom O, Fryklund B, Tullus K, Burman LG. A prospective nationwide study of Clostridium difficile-associated diarrhea in Sweden. Clin Inf Dis 1998; 26: 141-5.
5. Owens RC. Clostridium difficile associated disease: an emerging threat to patient safety. Pharmacotherapy 2006; 26: 299-311.
6. Beaugerie L, Flahaut A, Barbut F, Atlan P, Lalande V, Cousin P, Cadilhac M, Petit JC. Antibiotic-associated diarrhoea and Clostridium difficile int he community. Aliment Pharmacol Ther 2003; 17: 905-12.
7. Romero-Gomez M, Suarez GE, Castro FM. Pseudomembranous colitis induced by diclofenac. J Clin Gastroenterol 1998; 26: 228.
8. Gentric A, Pennec YL. Diclofenac-induced pseudomembranous colitis. Lancet 1992; 340: 126-7.
9. Lapoile E, Bellaiche G, Nouts A, Bahurel H, Ley G, Slama JL. Clostridium difficile pseudo-membranous colitic secondary to taking diclofenac. Gastroenterol Clin Biol 1998; 22: 100-1.
10. Jick H, Jick SS, Derby LE. Validation of information recorded on general practitioner based computerized data resource in the United Kingdom. Br Med J 1991; 302: 766-8.
11. Jick SS, Kaye JA, Vasilakis-Scaramozza C, Garcia Rodriguez LA, Ruigómez A, Meier CR, Schlienger RG, Black C, Jick H. Validity of the general practice research database. Pharmacotherapy 2003; 23: 686-9.
12. Lawrence R, Williams T, Farmer R. Clinical information for research; the use of general practice databases. J Public Health Med 1999; 21: 299-304.
13. th edn. Whitehouse Station, NJ, USA: Merck Publishing, 2006.
14. Dial S, Delaney JA, Schneider V, Suissa S. Proton pump inhibitor use and risk of community-acquired Clostridium difficile-associated disease defined by prescription for oral vancomycin therapy. Can Med Assoc J 2006; 175: 745-8.
15. Delaney JAC, Biggs ML, Kronmal RA, Psaty BM. Demographic, medical, and behavioral characteristics associated with over the counter non-steroidal anti-inflammatory drug use in a population-based cohort: results from the Multi-Ethnic Study of Atherosclerosis. Pharmacoepidemiol Drug Saf 2011; 20: 83-9.
16. Rothman KJ, Greenland S. In: Modern Epidemiology, 2nd edn. Philadelphia, PA: Lippincott Williams and Wilkins, 1998.
17. de Vries F, de Vries C, Cooper C, Leufkens B, van Staa TP. Reanalysis of two studies with contrasting results on the association between statin use and fracture risk: the General Practice Research Database. Int J Epidemiol 2006; 35: 1301-8.