Activation of cap-dependent translation by mucosal human papillomavirus E6 proteins is dependent on the integrity of the LXXLL binding motif

Journal of Virology

Volumn 86, Issue 14, 2012, Pages 7466-7472

  Spangle, Jennifer M ^a,b   Ghosh Choudhury, Nayana ^a   Munger, Karl ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN PAPILLOMAVIRUS E6 PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PDZ PROTEIN; UBIQUITIN PROTEIN LIGASE E3; UBIQUITIN PROTEIN LIGASE E3A; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ARTICLE; CORRELATION ANALYSIS; DNA BINDING MOTIF; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HUMAN PAPILLOMAVIRUS TYPE 11; HUMAN PAPILLOMAVIRUS TYPE 16; HUMAN PAPILLOMAVIRUS TYPE 18; HUMAN PAPILLOMAVIRUS TYPE 5; HUMAN PAPILLOMAVIRUS TYPE 6; HUMAN PAPILLOMAVIRUS TYPE 6B; HUMAN PAPILLOMAVIRUS TYPE 8; LIFE CYCLE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN MOTIF; SPECIES DIFFERENTIATION; VIRUS CELL TRANSFORMATION; VIRUS TRANSCRIPTION; WART VIRUS;

CELL LINE; HEK293 CELLS; HUMAN PAPILLOMAVIRUS 11; HUMAN PAPILLOMAVIRUS 16; HUMAN PAPILLOMAVIRUS 18; HUMANS; MUCOUS MEMBRANE; ONCOGENE PROTEINS, VIRAL; PDZ DOMAINS; PROTEIN BIOSYNTHESIS; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; REPRESSOR PROTEINS; TRANSCRIPTION FACTORS; UBIQUITIN-PROTEIN LIGASES;

HUMAN PAPILLOMAVIRUS; HUMAN PAPILLOMAVIRUS TYPE 16;

EID: 84863741533     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00487-12     Document Type: Article

References (30)

1. Brimer N, Lyons C, Vande Pol SB. 2007. Association of E6AP (UBE3A) with human papillomavirus type 11 E6 protein. Virology 358:303-310.
2. Chen JJ, Reid CE, Band V, Androphy EJ. 1995. Interaction of papillomavirus E6 oncoproteins with a putative calcium-binding protein. Science 269:529 -531.
3. Degenhardt YY, Silverstein SJ. 2001. Gps2, a protein partner for human papillomavirus E6 proteins. J. Virol. 75:151-160.
4. Elston RC, Napthine S, Doorbar J. 1998. The identification of a conserved binding motif within human papillomavirus type 16 E6 binding peptides, E6AP and E6BP. J. Gen. Virol. 79(Pt 2):371-374.
5. Feng W, Duan X, Liu J, Xiao J, Brown RE. 2009. Morphoproteomic evidence of constitutively activated and overexpressed mTOR pathway in cervical squamous carcinoma and high grade squamous intraepithelial lesions. Int. J. Clin. Exp. Pathol. 2:249 -260.
6. Geimanen J, et al. 2011. Development of a cellular assay system to study the genome replication of high- and low-risk mucosal and cutaneous human papillomaviruses. J. Virol. 85:3315-3329.
7. Howie HL, Katzenellenbogen RA, Galloway DA. 2009. Papillomavirus E6 proteins. Virology 384:324 -334.
8. Klingelhutz AJ, Foster SA, McDougall JK. 1996. Telomerase activation by the E6 gene product of human papillomavirus type 16. Nature 380:79 - 82.
9. Klingelhutz AJ, Roman A. 2012. Cellular transformation by human papillomaviruses: lessons learned by comparing high- and low-risk viruses. Virology 424:77-98.
10. Lin CY, et al. 2004. Discovery of estrogen receptor alpha target genes and response elements in breast tumor cells. Genome Biol. 5:R66. doi:10.1186/ gb-2004-5-9-r66.
11. Liu Y, et al. 1999. Multiple functions of human papillomavirus type 16 E6 contribute to the immortalization of mammary epithelial cells. J. Virol. 73:7297-7307.
12. Lu Z, et al. 2004. Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin. J. Biol. Chem. 279: 35664-35670.
13. Ma XM, Blenis J. 2009. Molecular mechanisms of mTOR-mediated translational control. Nat. Rev. Mol. Cell Biol. 10:307-318.
14. McLaughlin-Drubin ME, Huh KW, Munger K. 2008. Human papillomavirus type 16 E7 oncoprotein associates with E2F6. J. Virol. 82:8695- 8705.
15. McLaughlin-Drubin ME, Munger K. 2009. Oncogenic activities of human papillomaviruses. Virus Res. 143:195-208.
16. McLaughlin-Drubin ME, Munger K. 2009. The human papillomavirus E7 oncoprotein. Virology 384:335-344.
17. Mistry N, Simonsson M, Evander M. 2007. Transcriptional activation of the human papillomavirus type 5 and 16 long control region in cells from cutaneous and mucosal origin. Virol. J. 4:27.
18. Munger K, Phelps WC, Bubb V, Howley PM, Schlegel R. 1989. The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes. J. Virol. 63:4417- 4421.
19. Nawaz Z, et al. 1999. The Angelman syndrome-associated protein, E6-AP, is a coactivator for the nuclear hormone receptor superfamily. Mol. Cell. Biol. 19:1182-1189.
20. Oh KJ, Kalinina A, Park NH, Bagchi S. 2006. Deregulation of eIF4E: 4E-BP1 in differentiated human papillomavirus-containing cells leads to high levels of expression of the E7 oncoprotein. J. Virol. 80:7079 -7088.
21. Petersen CP, Bordeleau ME, Pelletier J, Sharp PA. 2006. Short RNAs repress translation after initiation in mammalian cells. Mol. Cell 21:533- 542.
22. Scheffner M, Huibregtse JM, Vierstra RD, Howley PM. 1993. The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell 75:495-505.
23. Schiffman M, Castle PE, Jeronimo J, Rodriguez AC, Wacholder S. 2007. Human papillomavirus and cervical cancer. Lancet 370:890 -907.
24. Sedman SA, et al. 1991. The full-length E6 protein of human papillomavirus type 16 has transforming and trans-activating activities and cooperates with E7 to immortalize keratinocytes in culture. J. Virol. 65:4860 - 4866.
25. Spangle JM, Munger K. 2010. The human papillomavirus type 16 E6 oncoprotein activates mTORC1 signaling and increases protein synthesis. J. Virol. 84:9398 -9407.
26. Thomas M, Banks L. 1999. Human papillomavirus (HPV) E6 interactions with Bak are conserved amongst E6 proteins from high and low risk HPV types. J. Gen. Virol. 80(Pt 6):1513-1517.
27. Thomas M, et al. 2008. Human papillomaviruses, cervical cancer and cell polarity. Oncogene 27:7018 -7030.
28. Tong X, Howley PM. 1997. The bovine papillomavirus E6 oncoprotein interacts with paxillin and disrupts the actin cytoskeleton. Proc. Natl. Acad. Sci. U. S. A. 94:4412- 4417.
29. Underbrink MP, Howie HL, Bedard KM, Koop JI, Galloway DA. 2008. E6 proteins from multiple human betapapillomavirus types degrade Bak and protect keratinocytes from apoptosis after UVB irradiation. J. Virol. 82:10408 -10417.
30. Vande Pol SB, Brown MC, Turner CE. 1998. Association of bovine papillomavirus type 1 E6 oncoprotein with the focal adhesion protein paxillin through a conserved protein interaction motif. Oncogene 16: 43-52.