IGFBP7 reduces breast tumor growth by induction of senescence and apoptosis pathways

Breast Cancer Research and Treatment

Volumn 133, Issue 2, 2012, Pages 563-573

  Benatar, Tania ^a   Yang, Wenyi ^a   Amemiya, Yutaka ^a   Evdokimova, Valentina ^a,b   Kahn, Harriette ^c   Holloway, Claire ^d   Seth, Arun ^a,c,e  

^a Sunnybrook Health Sciences Centre   (Canada)

^b INSTITUTE OF PROTEIN RESEARCH   (Russian Federation)

^c SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^d DEPARTMENT OF RADIATION ONCOLOGY   (Canada)

^e UNIVERSITY OF TORONTO   (Canada)

Author keywords

Apoptosis; Breast cancer; IGFBP7; P38 MAPK; Senescence; Tumor xenograft; VEGF

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; INSULIN LIKE GROWTH FACTOR BINDING PROTEIN 7; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN P53; RECOMBINANT INSULIN LIKE GROWTH FACTOR BINDING PROTEIN 7; SOMATOMEDIN BINDING PROTEIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIANGIOGENIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; BREAST TUMOR; CANCER GROWTH; CANCER INHIBITION; CARCINOGENICITY; CELL GROWTH; CELL MIGRATION; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVATION; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; SENESCENCE; TUMOR VOLUME; TUMOR XENOGRAFT; UPREGULATION;

ANIMALS; APOPTOSIS; BREAST NEOPLASMS; CELL AGING; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; FEMALE; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS; MICE; MICE, INBRED NOD; MICE, SCID; RECEPTOR, ERBB-2; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE; SIGNAL TRANSDUCTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84863724961     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-011-1816-4     Document Type: Article

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