Comparison of pre-cryopreserved and post-thaw-and-wash-nucleated cell count on major outcomes following unrelated cord blood transplant in children

Pediatric Transplantation

Volumn 16, Issue 5, 2012, Pages 438-442

  McManus, Meghann Pine ^a   Wang, Li ^b   Calder, Cassie ^c   Manes, Becky ^c   Evans, Misty ^c   Bruce, Kathryn ^c   Ho, Richard H ^c   Domm, Jennifer ^c   Frangoul, Haydar ^c  

^a PRIMARY CHILDREN'S MEDICAL CENTER   (United States)

^b MONROE CARELL JR CHILDREN S HOSPITAL AT VANDERBILT   (United States)

^c VANDERBILT UNIVERSITY   (United States)

Author keywords

cell dose; cord blood transplant; pediatrics; washing and thawing

Indexed keywords

BUSULFAN; CYCLOPHOSPHAMIDE; CYCLOSPORIN; MELPHALAN; METHYLPREDNISOLONE; THYMOCYTE ANTIBODY;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ARTICLE; CELL COUNT; CELL LOSS; CHILD; CORD BLOOD STEM CELL TRANSPLANTATION; CORD BLOOD UNIT; CRYOPRESERVATION; ENGRAFTMENT; FEMALE; GRAFT VERSUS HOST REACTION; HUMAN; INFANT; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; MORTALITY; NEUTROPHIL ENGRAFTMENT; NEWBORN; OUTCOME ASSESSMENT; PEDIATRIC SURGERY; POST THAW AND WASH; PRECRYOPRESERVATION; PRESCHOOL CHILD; SCHOOL CHILD; STORAGE DISEASE; THAWING; TOTAL NUCLEATED CELL COUNT; TRANSPLANT RELATED MORTALITY; UMBILICAL CORD BLOOD;

ADOLESCENT; BLOOD SPECIMEN COLLECTION; CELL COUNT; CHILD; CHILD, PRESCHOOL; CORD BLOOD STEM CELL TRANSPLANTATION; CRYOPRESERVATION; FEMALE; FETAL BLOOD; FOLLOW-UP STUDIES; HUMANS; INFANT; LEUKEMIA, MYELOID, ACUTE; MALE; MULTIVARIATE ANALYSIS; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 84863719592     PISSN: 13973142     EISSN: 13993046     Source Type: Journal    
DOI: 10.1111/j.1399-3046.2012.01698.x     Document Type: Article

References (13)

1. Barker JN, Scaradavou A, Stevens CE,. Combined effect of total nucleated cell dose and HLA match on transplantation outcome in 1061 cord blood recipients with hematologic malignancies. Blood 2010: 115: 1843-1849.
2. Wagner JE, Barker JN, Defor TE, et al., Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: Influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival. Blood 2002: 100: 1611-1618.
3. Kurtz J, Seetharaman S, Greco N, Moroff G,. Assessment of cord blood hematopoietic cell parameters before and after cryopreservation. Transfusion 2007: 47: 1578-1587.
4. Laroche V, McKenna DH, Moroff G, Schierman T, Kadidlo D, McCullough J,. Cell loss and recovery in umbilical cord blood processing: A comparison of postthaw and postwash samples. Transfusion 2005: 45: 1909-1916.
5. Wagner E, Duval M, Dalle JH, et al., Assessment of cord blood unit characteristics on the day of transplant: Comparison with data issued by cord blood banks. Transfusion 2006: 46: 1190-1198.
6. Rubenstein P, Dobrila L, Rosenfield RE, et al., Processing and cryopreservation of placental/umbilical cord blood for unrelated bone marrow reconstitution. Proc Natl Acad Sci U S A 1995: 92: 10119-10122.
7. Kurtzberg J, Prasad VK, Carter SL, et al., Results of the Cord Blood Transplantation Study (COBLT): Clinical outcomes of unrelated donor umbilical cord blood transplantation in pediatric patients with hematologic malignancies. Blood 2008: 112: 4318-4327.
8. Martin PL, Carter SL, Kernan NA, et al., Results of the cord blood transplantation study (COBLT): Outcomes of unrelated donor umbilical cord blood transplantation in pediatric patients with lysosomal and peroxisomal storage diseases. Biol Blood Marrow Transplant 2006: 12: 184-194.
9. Wall DA, Carter SL, Kernan NA, et al., Busulfan/melphalan/antithymocyte globulin followed by unrelated donor cord blood transplantation for treatment of infant leukemia and leukemia in young children: The Cord Blood Transplantation study (COBLT) experience. Biol Blood Marrow Transplant 2005: 11: 637-646.
10. Weisdorf DJ, Hurd D, Carter S, et al., Prospective grading of graft-versus-host disease after unrelated donor marrow transplantation: A grading algorithm versus blinded expert panel review. Biol Blood Marrow Transplant 2003: 9: 512-518.
11. Regan DM, Wofford JD, Wall DA,. Comparison of cord blood thawing methods on cell recovery, potency, and infusion. Transfusion 2010: 50: 2670-2675.
12. Rubinstein P, Carrier C, Scaradavou A, et al., Outcomes among 562 recipients of placental-blood transplants from unrelated donors. N Engl J Med 1998: 339: 1565-1577.
13. Eapen M, Rubinstein P, Zhang MJ, et al., Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: A comparison study. Lancet 2007: 369: 1947-1954.