Combined transfection of the three transcriptional factors, PDX-1, neuroD1, and MafA, causes differentiation of bone marrow mesenchymal stem cells into insulin-producing cells

Experimental Diabetes Research

Volumn 2012, Issue , 2012, Pages

  Guo, Qing Song ^a   Zhu, Ming Yan ^a   Wang, Lei ^a   Fan, Xiang Jun ^a   Lu, Yu Hua ^a   Wang, Zhi Wei ^a   Zhu, Sha Jun ^a   Wang, Yao ^a   Huang, Yan ^a  

^a NANTONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; NEUROGENIC DIFFERENTIATION FACTOR; STREPTOZOCIN; TRANSCRIPTION FACTOR MAFA; TRANSCRIPTION FACTOR PDX 1; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; HOMEODOMAIN PROTEIN; MAFA PROTEIN, MOUSE; NERVE PROTEIN; PANCREATIC AND DUODENAL HOMEOBOX 1 PROTEIN; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR MAF;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW MESENCHYMAL STEM CELL; CELL ADHESION; CELL DIFFERENTIATION; CELL FUNCTION; CONTROLLED STUDY; GENE EXPRESSION; GENE TARGETING; GENETIC TRANSFECTION; GLUCOSE BLOOD LEVEL; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; HYPERGLYCEMIA; IN VITRO STUDY; IN VIVO STUDY; INSULIN RELEASE; INSULIN SYNTHESIS; MALE; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; STREPTOZOCIN DIABETES; TARGET CELL; ADENOVIRUS; ANIMAL; BONE MARROW CELL; C57BL MOUSE; CELL STRAIN HEK293; CELL TRANSPLANTATION; CYTOLOGY; DIABETES MELLITUS; IMMUNOHISTOCHEMISTRY; METABOLISM; METHODOLOGY;

ADENOVIRIDAE; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL TRANSPLANTATION; DIABETES MELLITUS; HEK293 CELLS; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; INSULIN; INSULIN-SECRETING CELLS; MAF TRANSCRIPTION FACTORS, LARGE; MESENCHYMAL STEM CELLS; MICE; MICE, INBRED C57BL; NERVE TISSUE PROTEINS; TRANS-ACTIVATORS; TRANSFECTION;

EID: 84863713512     PISSN: 16875214     EISSN: 16875303     Source Type: Journal    
DOI: 10.1155/2012/672013     Document Type: Article

References (27)

1. Best M., Carroll M., Hanley N. A., Piper Hanley K., Embryonic stem cells to -cells by understanding pancreas development Molecular and Cellular Endocrinology 2008 288 1-2 86 94
2. Kim J. H., Shin K. H., Li T. Z., Suh H., Potential of nucleofected human MSCs for insulin secretion Journal of Tissue Engineering and Regenerative Medicine 2011 5 10 761 769
3. Li G., Luo R., Zhang J., Yeo K. S., Lian Q., Xie F., Tan E. K. W., Caille D., Kon O. L., Salto-Tellez M., Meda P., Lim S. K., Generating mESC-derived insulin-producing cell lines through an intermediate lineage-restricted progenitor line Stem Cell Research 2009 2 1 41 55
4. Naujok O., Francini F., Picton S., Bailey C. J., Lenzen S., Jrns A., Changes in gene expression and morphology of mouse embryonic stem cells on differentiation into insulin-producing cells in vitro and in vivo Diabetes/Metabolism Research and Reviews 2009 25 5 464 476
5. Bernardo A. S., Hay C. W., Docherty K., Pancreatic transcription factors and their role in the birth, life and survival of the pancreatic cell Molecular and Cellular Endocrinology 2008 294 1-2 1 9
6. Andrali S. S., Smapley M. L., Vanderford N. L., Ozcan S., Glucose regulation of insulin gene expression in pancreatic -cells Biochemical Journal 2008 415 1 1 10
7. Karaoz E., Aksoy A., Ayhan S., SarIboyacI A. E., Kaymaz F., Kasap M., Characterization of mesenchymal stem cells from rat bone marrow: ultrastructural properties, differentiation potential and immunophenotypic markers Histochemistry and Cell Biology 2009 132 5 533 546
8. Tonti G. A., Mannello F., From bone marrow to therapeutic applications: different behaviour and genetic/epigenetic stability during mesenchymal stem cell expansion in autologous and foetal bovine sera? International Journal of Developmental Biology 2008 52 8 1023 1032
9. Zhao S., Wehner R., Bornhauser M., Wassmuth R., Bachmann M., Schmitz M., Immunomodulatory properties of mesenchymal stromal cells and their therapeutic consequences for immune-mediated disorders Stem Cells and Development 2010 19 5 607 614
10. Karnieli O., Izhar-Prato Y., Bulvik S., Efrat S., Generation of insulin-producing cells from human bone marrow mesenchymal stem cells by genetic manipulation Stem Cells 2007 25 11 2837 2844 (Pubitemid 350127868)
11. Li Y., Zhang R., Qiao H., Zhang H., Wang Y., Yuan H., Liu Q., Liu D., Chen L., Pei X., Generation of insulin-producing cells from PDX-1 gene-modified human mesenchymal stem cells Journal of Cellular Physiology 2007 211 1 36 44 (Pubitemid 46363894)
12. Lu Y., Wang Z., Zhu M., Human bone marrow mesenchymal stem cells transfected with human insulin genes can secrete insulin stably Annals of Clinical and Laboratory Science 2006 36 2 127 136
13. Xu J., Lu Y., Ding F., Zhan X., Zhu M., Wang Z., Reversal of diabetes in mice by intrahepatic injection of bone-derived GFP-murine mesenchymal stem cells infected with the recombinant retrovirus-carrying human insulin gene World Journal of Surgery 2007 31 9 1872 1882 (Pubitemid 47283211)
14. Kim J., Lengner C. J., Kirak O., Hanna J., Cassady J. P., Lodato M. A., Wu S. U., Faddah D. A., Steine E. J., Qing G. A. O., Fu D., Dawlaty M., Jaenisch R., Reprogramming of postnatal neurons into induced pluripotent stem cells by defined factors Stem Cells 2011 29 6 992 1000
15. Ambasudhan R., Talantova M., Coleman R., Yuan X., Zhu S., Lipton S. A., Ding S., Direct reprogramming of adult human fibroblasts to functional neurons under defined conditions Cell Stem Cell 2011 9 2 113 118
16. Guo Z., Li H., Li X., Yu X., Wang H., Tang P., Mao N., In vitro characteristics and in vivo immunosuppressive activity of compact bone-derived murine mesenchymal progenitor cells Stem Cells 2006 24 4 992 1000 (Pubitemid 44464732)
17. Maxson S., Burg K. J. L., Conditioned media cause increases in select osteogenic and adipogenic differentiation markers in mesenchymal stem cell cultures Journal of Tissue Engineering and Regenerative Medicine 2008 2 2-3 147 154
18. Minami K., Seino S., Pancreatic acinar-to-beta cell transdifferentiation in vitro Frontiers in Bioscience 2008 13 5824 5837
19. Meivar-Levy I., Ferber S., Adult cell fate reprogramming: converting liver to pancreas Methods in Molecular Biology 2010 636 251 283
20. Miller K., Kim A., Kilimnik G., Jo J., Moka U., Periwal V., Hara M., Islet formation during the neonatal development in mice PLoS ONE 2009 4 11
21. Hay C. W., Docherty K., Comparative analysis of insulin gene promoters: implications for diabetes research Diabetes 2006 55 12 3201 3213 (Pubitemid 44923575)
22. Peshavaria M., Cissell M. A., Henderson E., Petersen H. V., Stein R., The PDX-1 activation domain provides specific functions necessary for transcriptional stimulation in pancreatic -cells Molecular Endocrinology 2000 14 12 1907 1917 (Pubitemid 32055525)
23. Kaneto H., Matsuoka T. A., Kawashima S., Yamamoto K., Kato K., Miyatsuka T., Katakami N., Matsuhisa M., Role of MafA in pancreatic -cells Advanced Drug Delivery Reviews 2009 61 7-8 489 496
24. Hagman D. K., Hays L. B., Parazzoli S. D., Poitout V., Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans The Journal of Biological Chemistry 2005 280 37 32413 32418 (Pubitemid 41361852)
25. Aramata S., Han S. I., Yasuda K., Kataoka K., Synergistic activation of the insulin gene promoter by the -cell enriched transcription factors MafA, Beta2, and Pdx1 Biochimica et Biophysica Acta 2005 1730 1 41 46 (Pubitemid 41008611)
26. Jung J., Zheng M., Goldfarb M., Zaret K. S., Initiation of mammalian liver development from endoderm by fibroblast growth factors Science 1999 284 5422 1998 2003 (Pubitemid 29309449)
27. Suzuki A., Zheng Y. W., Kaneko S., Onodera M., Fukao K., Nakauchi H., Taniguchi H., Clonal identification and characterization of self-renewing pluripotent stem cells in the developing liver Journal of Cell Biology 2002 156 1 173 184 (Pubitemid 34846945)