A rapid liquid chromatography-tandem mass spectrometry method for the determination of ciprofloxacin in rabbits serum following intragastric dosing: Application to pharmacokinetics study

Research Journal of Pharmacy and Technology

Volumn 5, Issue 5, 2012, Pages 624-631

  Abdel Hamid, Mohammed E ^a   Sharaf, Leyla H ^a   Phillips, Oludotun A ^a   Kehinde, Elijah O ^a   Babu, Alice ^a  

^a KUWAIT UNIVERSITY   (Kuwait)

Author keywords

Ciprofloxacin; LC MS MS; Pharmacokinetics study; Rabbits serum

Indexed keywords

CIPROFAR; CIPROFLOXACIN; CIPROTAB; RUFLOXACIN; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG HALF LIFE; DRUG RELEASE; DRUG STABILITY; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; LIMIT OF DETECTION; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRECIPITATION; RABBIT; SINGLE DRUG DOSE; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION;

EID: 84863709100     PISSN: 0974360X     EISSN: 09743618     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. De Sarro A and De Sarro G. Adverse reactions to fluoroquinolones. An overview on mechanistic aspects. Curr. Med. Chem.2001;8:371-384.
2. RxList: The Internet Drug Index-Ciprofloxacin 2009.
3. Kehinde EO, Sheikh M, Anim J, Al-Maghrebi M, Hussein A, John J. Addition of single dose amikacin to prophylactic quinolones significantly reduces infectious complications of transrectal ultrasound guided biopsy of the prostate gland. J. Urol. Suppl.2008, 179:717-718.
4. Kim BH, Choi NH, Ok JH. Comparison of reversed-phase liquid chromatographic methods for the separation of new quinolones. J. Chromatogr. Sci.2002, 40:369-376.
5. Imre S, Dogaru MT, Vari CE, Muntean T, Kelemen L. Validation of an HPLC method for the determination of ciprofloxacin in human plasma. J.Pharm.Biomed.Anal.2003, 33:125-130.
6. Sowinski KM and Kays MB. Determination of ciprofloxacin concentrations in human serum and urine by HPLC with ultraviolet and fluorescence detection. J. Clin. Pharm.Therap.2004, 29:381-387.
7. Ingeborg MG, Arther RHZ, Geert M. Reliable new highperformance liquid chromatographic method for the determination of ciprofloxacin in human serum. Ther. Drug. Monit.2006, 28:278-281.
8. Gonzalez C, Moreno L, Jones DG, Sanchez SF. A liquid chromatographic method, with fluorimetric detection, for the determination of enrofloxacin and ciprofloxacin in plasma and endometrial tissue of mares. Anal.Chim.Acta.2006,560:227-234.
9. Al-Ghazawi M, AbuRuz S. Determination of ciprofloxacin in dried blood spots for therapeutic drug monitoring. Chromatographia 2010, 71: 999-1005.
10. Falcao A, Celeste L, Pena A, Fortna A, Alves G, Sousa J. Development and validation of a fast isocratic liquid chromatography for the simultaneous determination of norfloxacin, lomefloxacin and ciprofloxacin in human plasma. Biomed. Chromatogr. 2011, 25:535-541.
11. Zafra-Gomez A, Garbello A, Ballesteros O, Navalon A, Garcia-Ayuso LE. Simultaneous determination of quinolone antibacterials in milk by liquid chromatography-mass spectrometry. Biomed. Chromatogr.2008, 22:1186-1193.
12. Roy B, Das A, Bhaumik U, Sarkar A, Bose A, Mukharjee J, Chakrabarty U, Das AK, Pal TK. Determination of gemifloxacin in different tissues of rat after oral dosing of gemifloxacin mesylate by LC-MS/MS and its application in drug tissue distribution study. J. Pharm. Biomed. Anal 2010, 52: 216-226.
13. Tamtam F, Mercier F, Eurin J, Chevreuil M, Le Bot B. Ultra performance liquid chromatography tandem mass spectrometry performance evaluation for analysis of antibiotics in natural waters. Anal. Bioanal. Chem.2009, 393:1709-1718.
14. Cai HL, Rose K, Liang LH, Dunham S, Stover C. Development of a liquid chromatography/mass spectrometry-based drug accumulation assay in Pseudomonas aeruginosa. Anal.Biochem.2009, 385: 321-325.
15. Zhang H, Ren YP, Bao XL. Simultaneous determination of fluoroquinolones antibacterial residues in bovine milk using ultra performance liquid chromatography-tandem mass spectrometry. J. Pharm. Biomed. Anal.2009, 49: 367-374.
16. Kaplan SA, Chung DE, Sandhu JS, Te AE. Generic substitutes are neither as safe nor effective as branded medications: Experience in men treated for lower urinary tract symptoms. J. Urol. Suppl.2009,181:649.