Induction of VEGF and MMP-9 expression by toll-like receptor 2/4 in human endothelial cells infected with Chlamydia pneumoniae

International Journal of Immunopathology and Pharmacology

Volumn 25, Issue 2, 2012, Pages 377-386

  Paolillo, R ^a   Iovene, M R ^a   Romano Carratelli, C ^a   Rizzo, A ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

Chlamydia pneumonite; MMP; TLR2; TLR4; VEGF

Indexed keywords

GELATINASE B; NEUTRALIZING ANTIBODY; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; VASCULOTROPIN; VASCULOTROPIN ANTIBODY; GELATIN;

ARTICLE; CELL PROLIFERATION; CHLAMYDIAL PNEUMONIA; CHLAMYDOPHILA PNEUMONIAE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; INCUBATION TEMPERATURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; UMBILICAL VEIN ENDOTHELIAL CELL; ZYMOGRAPHY; ATHEROSCLEROTIC PLAQUE; CARDIOVASCULAR SYSTEM; CELL PROLIFERATION ASSAY; CHLAMYDIA PNEUMONIAE; CONTROLLED STUDY; ENDOTHELIUM CELL; NONHUMAN;

EID: 84863707052     PISSN: 03946320     EISSN: None     Source Type: Journal    
DOI: 10.1177/039463201202500207     Document Type: Article

References (30)

1. Evani SJ, Murthy AK, Mareedu N, Montgomery RK, Arulanandam BP, Ramasubramanian AK. Hydrodynamic regulation of monocyte inflammatory response to an intracellular pathogen. PLoS One 2011; 6:e14492.
2. Muhlestein JB, Anderson JL. Chronic infection and coronary artery disease. Cardiol Clin 2003; 21:333-62.
3. Levi M, Keller TT, van Gorp E, ten Cate H. Infection and inflammation and the coagulation system. Cardiovasc Res 2003; 60:26-39. (Pubitemid 38373473)
4. Kern JM, Maass V, Maass M. Chlamydia pneumoniae-induced pathological signaling in the vasculature. FEMS Immunol Med Microbiol 2009; 55:131-39.
5. Fischer SF, Vier J, Kirschnek S, Klos A, Hess S, Ying S, Häcker G. Chlamydia inhibit host cell apoptosis by degradation of proapoptotic BH3-only proteins. J Exp Med 2004; 200:905-16. (Pubitemid 39362926)
6. Carratelli CR, Rizzo A, Catania MR, Gallè F, Losi E, Hasty DL, Rossano F. Chlamydia pneumoniae infections prevent the programmed cell death on THP-1 cell line. FEMS Microbiol Lett 2002; 215:69-74. (Pubitemid 35232585)
7. Kim MP, Gaydos CA, Wood BJ, Hardick JP, Zhang Y, Wahl LM. Chlamydia pneumoniae enhances cytokine-stimulated human monocyte matrix metalloproteinases through a prostaglandin E2-dependent mechanism. Infect Immun 2005; 73:632-4. (Pubitemid 40041161)
8. Vehmaan-Kreula P, Puolakkainen M, Sarvas M, Welgus HG, Kovanen PT. Chlamydia pneumoniae proteins induce secretion of the 92-kDa gelatinase by human monocyte-derived macrophages. Arterioscler Thromb Vasc Biol 2001; 21:E1-8.
9. Watson C, Alp NJ. Role of Chlamydia pneumoniae in atherosclerosis. Clin Sci (Lond) 2008; 114:509-31. (Pubitemid 351548759)
10. Romano Carratelli C, Nuzzo I, Cozzolino D, Bentivoglio C, Paolillo R, Rizzo A, Relationship between Chlamydia pneumoniae infection, inflammatory markers, and coronary heart diseases. Int Immunopharmacol 2006; 6:848-53.
11. Merkle M, Ribeiro A, Sauter M, Ladurner R, Mussack T, T. Sitter, M. Wörnle, Effect of activation of viral receptors on the gelatinases MMP-2 and MMP-9 in human mesothelial cells. Matrix Biol 2010; 29:202-8.
12. Hajishengallis G, Sharma A, Russell MW, Genco RJ. Interactions of oral pathogens with toll-like receptors, possible role in atherosclerosis. Ann Periodontol 2002; 7:72-8.
13. Joyee AG, Yang X. Role of toll-like receptors in immune responses to chlamydial infections. Curr Pharm Des 2008; 14:593-600. (Pubitemid 351516882)
14. Agarwal S, Misra R, Aggarwal A. Induction of metalloproteinases expression by TLR ligands in human fibroblast like synoviocytes from juvenile idiopathic arthritis patients. Indian J Med Res 2010; 131:771-9.
15. Galis ZS, Sukhova GK, Lark MW, Libby P. Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. J Clin Invest 1994; 94:2493-503. (Pubitemid 24379627)
16. Aikawa M, Rabkin E, Okada Y, Voglic SJ, Clinton SK, Brinckerhoff CE, Sukhova GK, Libby P. Lipid lowering by diet reduces matrix metalloproteinase activity and increases collagen content of rabbit atheroma, a potential mechanism of lesion stabilization. Circulation 1998; 97:2433-44. (Pubitemid 28278188)
17. Okamoto T, Akuta T, Tamura F, van Der Vliet A, Akaike T. Molecular mechanism for activation and regulation of matrix metalloproteinases during bacterial infections and respiratory inflammation. Biol Chem 2004; 385:997-1006. (Pubitemid 39600307)
18. Opdenakker G, Van den Steen PE, Dubois B, Nelissen I, Van Coillie E, Masure S, Proost P, Van Damme J. Gelatinase B functions as regulator and effector in leukocyte biology. J Leukoc Biol 2001; 69:851-9. (Pubitemid 32577883)
19. Shapiro SD. Diverse roles of macrophage matrix metalloproteinases in tissue destruction and tumor growth. Thromb Haemost 1999; 82:846-9.
20. Chakraborti S, Mandai M, Das S, Mandai A, Chakraborti T. Regulation of matrix metalloproteinases. Mol Cell Biochem 2003; 253:269-85.
21. Roblin PM, Dumornay W, Hammerschlang MR. Use of Hep-2 cells for improved isolation and passage of Chlamydia pneumoniae. J Clin Microbiol 1992; 30:1968-71.
22. Heussen C, Dowdle EB. Electrophoretic analysis of plasminogen activators in Polyacrylamide gels containing sodium dodecyl sulfate and copolymerized substrates. Anal Biochem 1980; 102:196-202. (Pubitemid 10099499)
23. Samal B, Sun Y, Stearns G, Xie C, Suggs S, McNiece I. Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor. Mol Cell Biol 1994; 14:1431-7.
24. Hamsa TP, Kuttan G. Harmine inhibits tumour specific neo-vessel formation by regulating VEGF, MMP, TIMP and pro-inflammatory mediators both in vivo and in vitro. Eur J Pharmacol 2010; 649:64-73.
25. Heo SH, Choi YJ, Ryoo HM, Cho JY Expression profiling of ETS and MMP factors in VEGF-activated endothelial cells, role of MMP-10 in VEGF-induced angiogenesis. J Cell Physiol 2010; 224:734-42.
26. Schachter J. Infection and disease epidemiology. In: Stephens RS, ed. Chlamydia: Intracellular Biology, Pathogenesis, and Immunity, Washington, D.C. ASM Press 1999; 139-69.
27. Krüll M, Bockstaller P, Wuppermann FN, et al. Mechanisms of Chlamydophila pneumoniae-mediated GM-CSF release in human bronchial epithelial cells. Am J Respir Cell Mol Biol 2006; 34:375-82. (Pubitemid 43320719)
28. Krull M, Kramp T, Petrov T, et al. Differences in cell activation by Chlamydia pneumoniae and Chlamydia trachomatis infection in human endothelial cells. Infect Immun 2004; 72:6615-21. (Pubitemid 39425444)
29. Schoneveld AH, Oude Nijhuis MM, van Middelaar B, Laman JD, de Kleijn DP, Pasterkamp G. Toll-like receptor 2 stimulation induces intimai hyperplasia and atherosclerotic lesion development. Cardiovasc Res 2005; 66:162-9. (Pubitemid 40357879)
30. Mullick A, Tobias PS, Curtiss LK. Modulation of atherosclerosis in mice by Toll-like receptor 2. J Clin Invest 2005; 115:3149-56. (Pubitemid 41567579)