Carnitine supplementation effects on nonenzymatic antioxidants in young rats submitted to exhaustive exercise stress

Journal of Strength and Conditioning Research

Volumn 26, Issue 6, 2012, Pages 1695-1700

  Bucioli, Sérvio A ^a   De Abreu, Luiz C ^b   Valenti, Vitor E ^b,c   Vannucchi, Helio ^b  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FACULDADE DE MEDICINA DO ABC   (Brazil)

^c SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Carnitine; Exercise; Free radicals; Stress

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; CARNITINE; GLUTATHIONE; MALONALDEHYDE;

ANIMAL; ANIMAL EXPERIMENT; ARTICLE; BLOOD; DIET SUPPLEMENTATION; DRUG EFFECT; EVALUATION; KIDNEY; LIPID PEROXIDATION; METABOLISM; OXIDATIVE STRESS; RANDOMIZATION; RAT; WISTAR RAT;

ANIMALS; ANTIOXIDANTS; CARNITINE; DIETARY SUPPLEMENTS; GLUTATHIONE; KIDNEY; LIPID PEROXIDATION; MALONDIALDEHYDE; OXIDATIVE STRESS; PHYSICAL CONDITIONING, ANIMAL; RANDOM ALLOCATION; RATS; RATS, WISTAR; VITAMIN E;

EID: 84863688437     PISSN: 10648011     EISSN: None     Source Type: Journal    
DOI: 10.1519/JSC.0b013e318234ebcb     Document Type: Article

References (40)

1. Arnaud, J, Fortis, I, Blachier, S, Kia, D, and Favier, A. Simultaneous determination of retinol, alpha-tocoferol and beta-carotene in serum by isocratic high-performance liquid chromatography. J Chomatogr 572: 103-116, 1991.
2. Aydin, C, Sonat, F, Sahin, SK, Cangul, IT, and Ozkaya, G. Long term dietary restriction ameliorates swimming exercise-induced oxidative stress in brain and lung of middle-aged rat. Ind J Exp Biol 47: 24-31, 2009.
3. Banudevi, S, Krishnamoorthy, G, and Venkataraman, P. Role of alpha-tocopherol on antioxidant status in liver, lung and kidney of PCB exposed male albino rats. Food Chem Toxicol 44: 2040-2046, 2006.
4. Bremer, J. Carnitine-Metabolism and functions. Physiol Rev 63: 1420-1480, 1983.
5. Buege, JA and Aust, SD. Microsomal lipid peroxidation. Meth Enzymol 52: 302-310, 1978.
6. Cao, Y, Qu, HJ, Li, P, Wang, CB, Wang, LX, and Han, ZW. Single dose administration of L-carnitine improves antioxidant activities in healthy subjects. Tohoku J Exp Med 224: 209-213, 2011.
7. Chang, B, Nishikavva, M, Sato, E, Utsumi, K, and Inoue M. LCarnitine inhibits cisplatin-induced injury of the kidney and small intestine. Arch Biochem Biophys 405: 55-64, 2002.
8. Cooper, CE, Vollaard, NB, Choueiri, T, andWilson, MT. Exercise, free radicals and oxidative stress. Biochem Soc Trans 30: 280-285, 2002.
9. Coronel, I, Arellano-Mendoza, MG, del Valle-Mondragon, L, Vargas-Robles, H, Castorena-Torres, F, Romo, E, Rios, A, and Escalante, B. L-Arginine and antioxidant diet supplementation partially restores nitric oxide-dependent regulation of phenylephrine renal vasoconstriction in diabetics rats. J Ren Nutr 20: 158-168, 2010.
10. Daud, FV, Murad, N, Meneghini, A, Ferreira, M, Ferreira Filho, C, Abreu, LC, Valenti, VE, and Ferreira, C. Fluoxetine effects on mitochondrial ultrastructure of right ventricle in rats exposed to cold stress. Rev Bras Cir Cardiovasc 24: 173-179, 2009.
11. Ewans, W. Vitamin E, vitamin C, and exercise. Am J Clin Nutr 72: 647-652, 2000.
12. Fatouros, IG, Douroudos, I, Panagoutsos, S, Pasadakis, P, Nikolaidis, MG, Chatzinikolaou, A, Sovatzidis, A, Michailidis, Y, Jamurtas, AZ, Mandalidis, D, Taxildaris, K, andVargemezis, V. Effects of L-carnitine on oxidative stress responses in patients with renal disease. Med Sci Sports Exerc 42: 1809-1818, 2010.
13. Golbidi, S, Ebadi, SA, and Laher, I. Antioxidants in the treatment of diabetes. Curr Diab Rev 7: 106-125, 2011.
14. Gulcin, I. Antioxidant and antiradical activities of L-carnitine. Life Sci 78: 803-811, 2006
15. Halliwell, B and Gutteridge, JMC. Free Radicals in Biology and Medicine. New York, NY: Oxford University Press, 1999.
16. Halsted, CH. Dietary supplements and the American journal of clinical nutrition. Am J Clin Nutr 71: 399-400, 2000.
17. Harper, P, Elwin, CE, and Cederblad, G. Pharmacokinetics of bolus intravenous and oral doses of L-carnitine in healthy subjects. Eur J Clin Pharmacol 35: 69-75, 1988.
18. Hinchcliff, KW, Reinhart, GA, DiSilvestro, R, Reynolds, A, Blostein-Fujii, A, and Swenson, RA. Oxidant stress in sled dogs subjected to repetitive endurance exercise. Am J Vet Res 61: 512-517, 2000.
19. Itoh, M, Oh-Ishi, S, Hatao, H, Leeuwenburgh, C, Selman, C, Ohno, H, Kizaki, T, Nakamura, H, and Matsuoka, T. Effects of dietary calcium restriction and acute exercise on the antioxidant enzyme system and oxidative stress in rat diaphragm. Am J Physiol Regul Integr Comp Physiol 287: R33-R38, 2004.
20. Ji, LL. Antioxidants and oxidative stress in exercise. Proc Soc Exp Biol Med 222: 283-292, 1999.
21. Kabasakalis, A, Kyparos, A, Tsalis, G, Loupos, D, Pavlidou, A, and Kouretas, D. Blood oxidative stress markers after ultramarathon swimming. J Strength Cond Res 25: 805-811, 2011.
22. Kawai, Y, Shimomitsu, T, Takanami, Y, Murase, N, Katsumura, T, and Maruyama, C. Vitamin E level changes in serum and red blood cells due to acute exhaustive exercise in collegiate women. J Nutr Sci Vit 46: 119-124, 2000.
23. Kopple, JD, Ding, H, Letoha, A, Ivanyi, B, Qing, DP, Dux, L, Wang, HY, and Sonkodi, S. L-Carnitine ameliorates gentamicininduced renal injury in rats. Nephrol Dial Transpl 17: 2122-2131, 2002.
24. Liu, J, Yeo, HC, Overvik-Douki, E, Hagen, T, Doniger, SJ, Chyu, DW, Brooks, GA, and Ames, BN. Chronically and acutely exercised rats: Biomarks of oxidative stress and endogenous antioxidants. J Appl Physiol 89: 21-28, 2000.
25. Lowry, OH, Rosebrough, NJ, Farr, AL, and Randall, RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275, 1952.
26. Luck, MR, Jeyaseelan, I, and Scholes, RA. Ascorbic acid and fertility. Biol Reprod 52: 262-266, 1995.
27. Meneghini, A, Ferreira, C, Abreu, LC, Ferreira, M, Ferreira Filho, C, Valenti, VE, and Murad, N. Cold stress effects on cardiomyocytes nuclear size in rats: Light microscopic evaluation. Rev Bras Cir Cardiovasc 23: 530-533, 2008.
28. Meneghini, A, Ferreira, C, Abreu, LC, Valenti, VE, Ferreira, M, F Filho, C, and Murad, N. Memantine prevents cardiomyocytes nuclear size reduction in the left ventricle of rats exposed to cold stress. Clinics 64: 921-926, 2009.
29. Moosavi, SM, Ashtiyani, SC, and Hosseinkhani, S. L-Carnitine improves oxidative stress and suppressed energy metabolism but not renal dysfunction following release of acute unilateral ureteral obstruction in rat. Neurourol Urodyn doi: 10.1002/ nau.21035.
30. Naziroǧlu, M, Kilincx, F, Uǧuz, AC, Celik, O, Bal, R, Butterworth, PJ, and Baydar, ML. Oral vitamin C and E combination modulates blood lipid peroxidation and antioxidant vitamin levels in maximal exercising basketball players. Cell Biochem Funct 28: 300-305, 2010.
31. Ohishi, S, Kizaki, T, Ookawara, T, Toshinai, K, Haga, S, Karasawa, F, Satoh, T, Nagata, N, Ji, LL, and Ohno, H. The effect of exhaustive exercise on the antioxidant enzyme system in skeletal muscle from calcium-deficient rats. Pflugers Arch 435: 767-774, 1998.
32. Palayo, P, Alberty, M, Sidney, M, Potdevin, F, and Dekerle, J. Aerobic potential, stroke parameters, and coordination in swimming front-crawl performance. Int J Sports Physiol Perform 2: 347-359, 2007.
33. Radak, Z, Kaneko, T, and Tahara, S. The effect of exercise training on oxidative damage of lipids, proteins, and DNA in rat skeletal muscle: Evidence for beneficial outcomes. Free Radic Biol Med 27: 69-74, 1999.
34. Sabry, AA. The role of oral L-carnitine therapy in chronic hemodialysis patients. Saudi J Kidney Dis Transpl 21: 454-459, 2010.
35. Sedlak, J and Lindsay, RH. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal Biochem 25: 192-205, 1968.
36. Sen, CK. Antioxidants and redox regulation of cellular signaling: Introduction. Med Sci Sports Exerc 33: 368-370, 2001.
37. Türker, Y, Naziroǧlu, M, Gümral, N, Celik, O, Saygin, M, Cömlekcxi, S, and Flores-Arce, M. Selenium and L-carnitine reduce oxidative stress in the heart of rat induced by 2.45-GHz radiation from wireless devices. Biol Trace Elem Res. Epub ahead of print.
38. Valenti, VE, Abreu, LC, Sato, MA, and Ferreira, C. ATZ (3-amino-1, 2, 4-triazole) injected into the fourth cerebral ventricle influences the Bezold-Jarisch reflex in conscious rats. Clinics 65: 1339-1343, 2010.
39. Vanella, A, Russo, A, Acquaviva, R, Campisi, A, Di Giacomo, C, Sorrenti, V, and Barcellona, ML. l-Propionyl-carnitine as superoxide scavenger, antioxidant, and DNA cleavage protector. Cell Biol Toxicol 16: 99-104, 2000.
40. Ye, J, Li, J, Yu, Y, Wei, Q, Deng, W, and Yu, L. L-Carnitine attenuates oxidant injury in HK-2 cells via ROS-mitochondria pathway. Regul Pept 161: 58-66, 2010.