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Volumn 19, Issue 8, 2012, Pages 525-536

Hepatitis C therapy in non-genotype 1 patients: The near future

Author keywords

cyclophilin inhibitors; direct antiviral agent combination; HC; hepatitis C; interferon lambda; nitazoxanide; non genotype 1; NS5A inhibitors; pegylated interferon; protease inhibitors; ribavirin; RNA polymerase inhibitors; silibinin; vitamin D

Indexed keywords

4A PROTEASE INHIBITOR; ALISPORIVIR; ANTIVIRUS AGENT; ASUNAPREVIR; BOCEPREVIR; CYCLOPHILIN INHIBITOR; DACLATASVIR; DANOPREVIR; DEB 025; DIRECT ANTIVIRAL AGENT; MERICITABINE; MK 5172; N (2' DEOXY 2' FLUORO 2' METHYL P PHENYL 5' URIDYLYL)ALANINE ISOPROPYL ESTER; NONNUCLEOSIDE INHIBITOR; NONSTRUCTURAL PROTEIN 3 INHIBITOR; NS5A COMPLEX INHIBITOR; NS5B RNA POLYMERASE; NUCLEOTIDE INHIBITOR; PEGINTERFERON ALPHA; RIBAVIRIN; SILIBININ; SIMEPREVIR; TELAPREVIR; UNCLASSIFIED DRUG;

EID: 84863649118     PISSN: 13520504     EISSN: 13652893     Source Type: Journal    
DOI: 10.1111/j.1365-2893.2012.01634.x     Document Type: Review
Times cited : (27)

References (53)
  • 1
    • 79953173221 scopus 로고    scopus 로고
    • Boceprevir for untreated chronic HCV genotype 1 infection
    • Poordad F, McCone Jr J, Bacon BR, et al. Boceprevir for untreated chronic HCV genotype 1 infection. N Engl J Med 2011; 364: 1195-1206.
    • (2011) N Engl J Med , vol.364 , pp. 1195-1206
    • Poordad, F.1    McCone, Jr.J.2    Bacon, B.R.3
  • 2
    • 79959438789 scopus 로고    scopus 로고
    • Telaprevir for previously untreated chronic hepatitis C virus infection
    • Jacobson IM, McHutchison JG, Dusheiko G, et al. Telaprevir for previously untreated chronic hepatitis C virus infection. N Engl J Med 2011; 364: 2405-2416.
    • (2011) N Engl J Med , vol.364 , pp. 2405-2416
    • Jacobson, I.M.1    McHutchison, J.G.2    Dusheiko, G.3
  • 3
    • 80052826527 scopus 로고    scopus 로고
    • Response-guided telaprevir combination treatment for hepatitis C virus infection
    • Sherman KE, Flamm SL, Afdhal NH, et al. Response-guided telaprevir combination treatment for hepatitis C virus infection. N Engl J Med 2011; 365: 1014-1024.
    • (2011) N Engl J Med , vol.365 , pp. 1014-1024
    • Sherman, K.E.1    Flamm, S.L.2    Afdhal, N.H.3
  • 4
    • 79953176289 scopus 로고    scopus 로고
    • Boceprevir for previously treated chronic HCV genotype 1 infection
    • Bacon BR, Gordon SC, Lawitz E, et al. Boceprevir for previously treated chronic HCV genotype 1 infection. N Engl J Med 2011; 364: 1207-1217.
    • (2011) N Engl J Med , vol.364 , pp. 1207-1217
    • Bacon, B.R.1    Gordon, S.C.2    Lawitz, E.3
  • 5
    • 79959381354 scopus 로고    scopus 로고
    • Telaprevir for retreatment of HCV infection
    • Zeuzem S, Andreone P, Pol S, et al. Telaprevir for retreatment of HCV infection. N Engl J Med 2011; 364: 2417-2428.
    • (2011) N Engl J Med , vol.364 , pp. 2417-2428
    • Zeuzem, S.1    Andreone, P.2    Pol, S.3
  • 6
    • 79960453276 scopus 로고    scopus 로고
    • EASL Clinical Practice Guidelines: Management of hepatitis C virus infection
    • EASL Clinical Practice Guidelines: management of hepatitis C virus infection. J Hepatol 2011; 55: 245-264.
    • (2011) J Hepatol , vol.55 , pp. 245-264
  • 7
    • 80052024078 scopus 로고    scopus 로고
    • Response-guided peg-interferon plus ribavirin treatment duration in chronic hepatitis C: Meta-analyses of randomized, controlled trials and implications for the future
    • Di Martino V, Richou C, Cervoni JP, et al. Response-guided peg-interferon plus ribavirin treatment duration in chronic hepatitis C: meta-analyses of randomized, controlled trials and implications for the future. Hepatology 2011; 54: 789-800.
    • (2011) Hepatology , vol.54 , pp. 789-800
    • Di Martino, V.1    Richou, C.2    Cervoni, J.P.3
  • 8
    • 77949831342 scopus 로고    scopus 로고
    • Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: A genome-wide association study
    • Rauch A, Kutalik Z, Descombes P, et al. Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study. Gastroenterology 2010; 138: 1338-1345, 45.
    • (2010) Gastroenterology , vol.138 , pp. 1338-1345
    • Rauch, A.1    Kutalik, Z.2    Descombes, P.3
  • 9
    • 77952693487 scopus 로고    scopus 로고
    • Replicated association between an IL28B gene variant and a sustained response to pegylated interferon and ribavirin
    • McCarthy JJ, Li JH, Thompson A, et al. Replicated association between an IL28B gene variant and a sustained response to pegylated interferon and ribavirin. Gastroenterology 2010; 138: 2307-2314.
    • (2010) Gastroenterology , vol.138 , pp. 2307-2314
    • McCarthy, J.J.1    Li, J.H.2    Thompson, A.3
  • 10
    • 79952214262 scopus 로고    scopus 로고
    • IL28B genetic variation and treatment response in patients with hepatitis C virus genotype 3 infection
    • Moghaddam A, Melum E, Reinton N, et al. IL28B genetic variation and treatment response in patients with hepatitis C virus genotype 3 infection. Hepatology 2011; 53: 746-754.
    • (2011) Hepatology , vol.53 , pp. 746-754
    • Moghaddam, A.1    Melum, E.2    Reinton, N.3
  • 11
    • 79951679619 scopus 로고    scopus 로고
    • Importance of IL28B gene polymorphisms in hepatitis C virus genotype 2 and 3 infected patients
    • Sarrazin C, Susser S, Doehring A, et al. Importance of IL28B gene polymorphisms in hepatitis C virus genotype 2 and 3 infected patients. J Hepatol 2011; 54: 415-421.
    • (2011) J Hepatol , vol.54 , pp. 415-421
    • Sarrazin, C.1    Susser, S.2    Doehring, A.3
  • 12
    • 84925580987 scopus 로고    scopus 로고
    • An IL28B polymorphism determines treatment response of hepatitis C virus genotype 2 or 3 patients who do not achieve a rapid virologic response
    • Mangia A, Thompson AJ, Santoro R, et al. An IL28B polymorphism determines treatment response of hepatitis C virus genotype 2 or 3 patients who do not achieve a rapid virologic response. Gastroenterology 2010; 139: 821-827, 7.
    • (2010) Gastroenterology , vol.139 , pp. 821-827
    • Mangia, A.1    Thompson, A.J.2    Santoro, R.3
  • 13
    • 79956074037 scopus 로고    scopus 로고
    • Management of hepatitis C virus genotype 4: Recommendations of an international expert panel
    • Khattab MA, Ferenci P, Hadziyannis SJ, et al. Management of hepatitis C virus genotype 4: recommendations of an international expert panel. J Hepatol 2011; 54: 1250-1262.
    • (2011) J Hepatol , vol.54 , pp. 1250-1262
    • Khattab, M.A.1    Ferenci, P.2    Hadziyannis, S.J.3
  • 14
    • 79952899824 scopus 로고    scopus 로고
    • Impact of IL28B genotype on the early and sustained virologic response in treatment-naive patients with chronic hepatitis C
    • Stattermayer AF, Stauber R, Hofer H, et al. Impact of IL28B genotype on the early and sustained virologic response in treatment-naive patients with chronic hepatitis C. Clin Gastroenterol Hepatol 2011; 9: 344-350.
    • (2011) Clin Gastroenterol Hepatol , vol.9 , pp. 344-350
    • Stattermayer, A.F.1    Stauber, R.2    Hofer, H.3
  • 15
    • 84857359539 scopus 로고    scopus 로고
    • IL28B polymorphism is associated with treatment response in patients with genotype 4 chronic hepatitis C
    • Asselah T, De Muynck S, Broet P, et al. IL28B polymorphism is associated with treatment response in patients with genotype 4 chronic hepatitis C. J Hepatol 2012; 56: 527-532.
    • (2012) J Hepatol , vol.56 , pp. 527-532
    • Asselah, T.1    De Muynck, S.2    Broet, P.3
  • 16
    • 84863714689 scopus 로고    scopus 로고
    • An optimal duration of treatment for chronic hepatitis C genotype 6 patients
    • Pham TTT, Ho TD,. An optimal duration of treatment for chronic hepatitis C genotype 6 patients. Hepatology 2011; 54 (Suppl.): 810A-811A.
    • (2011) Hepatology , vol.54 , Issue.SUPPL.
    • Pham, T.T.T.1    Ho, T.D.2
  • 18
    • 84863700658 scopus 로고    scopus 로고
    • Worldwide experience treating chronic hepatitis C with peginterferon alfa/ribavirin: Final results from 7163 naive mono-infected patients enrolled in the large multinational PROPHESYS cohort study
    • Marcellin P, Cheinquer H, Curescu M, et al. Worldwide experience treating chronic hepatitis C with peginterferon alfa/ribavirin: final results from 7163 naive mono-infected patients enrolled in the large multinational PROPHESYS cohort study. Hepatology 2011; 54 (Suppl.): 824A.
    • (2011) Hepatology , vol.54 , Issue.SUPPL.
    • Marcellin, P.1    Cheinquer, H.2    Curescu, M.3
  • 19
    • 84861109701 scopus 로고    scopus 로고
    • Treatment results of chronic hepatitis C genotype 5 and 6 infections in Germany
    • Mauss S, Berger F, Vogel M, et al. Treatment results of chronic hepatitis C genotype 5 and 6 infections in Germany. Z Gastroenterol 2012; 50: 441-444.
    • (2012) Z Gastroenterol , vol.50 , pp. 441-444
    • Mauss, S.1    Berger, F.2    Vogel, M.3
  • 20
    • 80052116134 scopus 로고    scopus 로고
    • Telaprevir alone or with peginterferon and ribavirin reduces HCV RNA in patients with chronic genotype 2 but not genotype 3 infections
    • Foster GR, Hezode C, Bronowicki JP, et al. Telaprevir alone or with peginterferon and ribavirin reduces HCV RNA in patients with chronic genotype 2 but not genotype 3 infections. Gastroenterology 2011; 141: 881-889.
    • (2011) Gastroenterology , vol.141 , pp. 881-889
    • Foster, G.R.1    Hezode, C.2    Bronowicki, J.P.3
  • 22
    • 78751631356 scopus 로고    scopus 로고
    • Activity of telaprevir or in combination with peginterferon alfa-2a and ribavirin in treatment naive genotype 4 hepatitis C patients. Final results of study C210
    • Benhamou Y, Moussalli J, Ratziu V, et al. Activity of telaprevir or in combination with peginterferon alfa-2a and ribavirin in treatment naive genotype 4 hepatitis C patients. Final results of study C210. Hepatology 2010; 52 (Suppl.): 719A-720A.
    • (2010) Hepatology , vol.52 , Issue.SUPPL.
    • Benhamou, Y.1    Moussalli, J.2    Ratziu, V.3
  • 23
    • 80052123459 scopus 로고    scopus 로고
    • Differential efficacy of protease inhibitors against HCV genotypes 2a, 3a, 5a, and 6a NS3/4A protease recombinant viruses
    • Gottwein JM, Scheel TK, Jensen TB, Ghanem L, Bukh J,. Differential efficacy of protease inhibitors against HCV genotypes 2a, 3a, 5a, and 6a NS3/4A protease recombinant viruses. Gastroenterology 2011; 141: 1067-1079.
    • (2011) Gastroenterology , vol.141 , pp. 1067-1079
    • Gottwein, J.M.1    Scheel, T.K.2    Jensen, T.B.3    Ghanem, L.4    Bukh, J.5
  • 24
    • 65749112245 scopus 로고    scopus 로고
    • In vitro activity and preclinical profile of TMC435350, a potent hepatitis C virus protease inhibitor
    • Lin TI, Lenz O, Fanning G, et al. In vitro activity and preclinical profile of TMC435350, a potent hepatitis C virus protease inhibitor. Antimicrob Agents Chemother 2009; 53: 1377-1385.
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 1377-1385
    • Lin, T.I.1    Lenz, O.2    Fanning, G.3
  • 25
    • 84863640239 scopus 로고    scopus 로고
    • MK-5172, a next generation HCV NS3/4A protease inhibitor is active against common resistance associated variants (RAVS) and exhibits cross genotype activity
    • Barnard RJ, Graham D, Acosta A, et al. MK-5172, a next generation HCV NS3/4A protease inhibitor is active against common resistance associated variants (RAVS) and exhibits cross genotype activity. Global Antiviral Journal 2011; 7 (Suppl. 1), HEP DART 2011; Abstract 108: 99.
    • (2011) Global Antiviral Journal , vol.7 , Issue.SUPPL. 1 , pp. 99
    • Barnard, R.J.1    Graham, D.2    Acosta, A.3    Hep Dart, E.4
  • 26
    • 80052070428 scopus 로고    scopus 로고
    • The HCV NS5B nucleoside and non-nucleoside inhibitors
    • Membreno FE, Lawitz EJ,. The HCV NS5B nucleoside and non-nucleoside inhibitors. Clin Liver Dis 2011; 15: 611-626.
    • (2011) Clin Liver Dis , vol.15 , pp. 611-626
    • Membreno, F.E.1    Lawitz, E.J.2
  • 27
    • 80051939098 scopus 로고    scopus 로고
    • The NS5A replication complex inhibitors: Difference makers?
    • Gish RG, Meanwell NA,. The NS5A replication complex inhibitors: difference makers? Clin Liver Dis 2011; 15: 627-639.
    • (2011) Clin Liver Dis , vol.15 , pp. 627-639
    • Gish, R.G.1    Meanwell, N.A.2
  • 28
    • 77952035218 scopus 로고    scopus 로고
    • Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect
    • Gao M, Nettles RE, Belema M, et al. Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect. Nature 2010; 465: 96-100.
    • (2010) Nature , vol.465 , pp. 96-100
    • Gao, M.1    Nettles, R.E.2    Belema, M.3
  • 29
    • 33646015668 scopus 로고    scopus 로고
    • The non-immunosuppressive cyclosporin DEBIO-025 is a potent inhibitor of hepatitis C virus replication in vitro
    • Paeshuyse J, Kaul A, De Clercq E, et al. The non-immunosuppressive cyclosporin DEBIO-025 is a potent inhibitor of hepatitis C virus replication in vitro. Hepatology 2006; 43: 761-770.
    • (2006) Hepatology , vol.43 , pp. 761-770
    • Paeshuyse, J.1    Kaul, A.2    De Clercq, E.3
  • 30
    • 55249084176 scopus 로고    scopus 로고
    • Silibinin is a potent antiviral agent in patients with chronic hepatitis C not responding to pegylated interferon/ribavirin therapy
    • Ferenci P, Scherzer TM, Kerschner H, et al. Silibinin is a potent antiviral agent in patients with chronic hepatitis C not responding to pegylated interferon/ribavirin therapy. Gastroenterology 2008; 135: 1561-1567.
    • (2008) Gastroenterology , vol.135 , pp. 1561-1567
    • Ferenci, P.1    Scherzer, T.M.2    Kerschner, H.3
  • 31
    • 79960443884 scopus 로고    scopus 로고
    • Pegylated interferon lambda shows superior viral response with improved safety and tolerability versus PegIFN alfa-2A in HCV patients (G1/2/3/4): EMERGE phase IIB through week 12
    • Zeuzem S, Arora S, Bacon B, et al. Pegylated interferon lambda shows superior viral response with improved safety and tolerability versus PegIFN alfa-2A in HCV patients (G1/2/3/4): EMERGE phase IIB through week 12. J Hepatol 2011; 54: S538-S539.
    • (2011) J Hepatol , vol.54
    • Zeuzem, S.1    Arora, S.2    Bacon, B.3
  • 32
    • 84863655459 scopus 로고    scopus 로고
    • Pegylated interferon lambda ameliorates ribavirin-induced anemia in HCV patients by maintaining compensatory erythropoiesis: Analysis of emerge phase 2B results through week 12
    • Everson GT, Gray TE, Hillson JL, et al. Pegylated interferon lambda ameliorates ribavirin-induced anemia in HCV patients by maintaining compensatory erythropoiesis: analysis of emerge phase 2B results through week 12. Hepatology 2011; 54: 993A-994A.
    • (2011) Hepatology , vol.54
    • Everson, G.T.1    Gray, T.E.2    Hillson, J.L.3
  • 33
    • 84863712408 scopus 로고    scopus 로고
    • Safety and efficacy of pegylated interferon lambda compared to pegylated interferon alfa-2A in HCV-infected patients G1/2/3 with compensated cirrhosis: EMERGE phase 2b efficacy and safety results through week 12
    • Rodriguez-Torres M, Hillson JL, Bacon BR, et al. Safety and efficacy of pegylated interferon lambda compared to pegylated interferon alfa-2A in HCV-infected patients G1/2/3 with compensated cirrhosis: EMERGE phase 2b efficacy and safety results through week 12. Hepatology 2011; 54: 994A.
    • (2011) Hepatology , vol.54
    • Rodriguez-Torres, M.1    Hillson, J.L.2    Bacon, B.R.3
  • 34
    • 83755196636 scopus 로고    scopus 로고
    • Vitamin D supplementation improves sustained virologic response in chronic hepatitis C (genotype 1)-naive patients
    • Abu-Mouch S, Fireman Z, Jarchovsky J, Zeina AR, Assy N,. Vitamin D supplementation improves sustained virologic response in chronic hepatitis C (genotype 1)-naive patients. World J Gastroenterol 2011; 17: 5184-5190.
    • (2011) World J Gastroenterol , vol.17 , pp. 5184-5190
    • Abu-Mouch, S.1    Fireman, Z.2    Jarchovsky, J.3    Zeina, A.R.4    Assy, N.5
  • 35
    • 84861188748 scopus 로고    scopus 로고
    • Antiviral activity of TMC435 monotherapy in patients infected with HCV genotypes 2-6: TMC435-C202, a phase IIa, open-label study
    • Moreno C, Berg T, Tanwandee T, et al. Antiviral activity of TMC435 monotherapy in patients infected with HCV genotypes 2-6: TMC435-C202, a phase IIa, open-label study. J Hepatol 2012; 56: 1247-1253.
    • (2012) J Hepatol , vol.56 , pp. 1247-1253
    • Moreno, C.1    Berg, T.2    Tanwandee, T.3
  • 36
    • 84863676547 scopus 로고    scopus 로고
    • Safety and antiviral activity of MK-5172, a next generation HCV NS3/4A protease inhibitor with a broad HCV genotypic activity spectrum and potent activity against known resistance mutants in genotype 1 and 3 HCV infected patients
    • Peltry AS, Fraser IP, O'Mara E, et al. Safety and antiviral activity of MK-5172, a next generation HCV NS3/4A protease inhibitor with a broad HCV genotypic activity spectrum and potent activity against known resistance mutants in genotype 1 and 3 HCV infected patients. Hepatology 2011; 54 (Suppl.): 531A.
    • (2011) Hepatology , vol.54 , Issue.SUPPL.
    • Peltry, A.S.1    Fraser, I.P.2    O'Mara, E.3
  • 37
    • 77958162291 scopus 로고    scopus 로고
    • Sustained virologic response following RG7128 1500mg BID/PEG-IFN/RBV for 28 days in HCV genotype 2/3 prior non responders
    • Gane EJ, Rodriguez-Torres M, Nelson DE, et al. Sustained virologic response following RG7128 1500mg BID/PEG-IFN/RBV for 28 days in HCV genotype 2/3 prior non responders. J Hepatol 2010; 52: S16.
    • (2010) J Hepatol , vol.52
    • Gane, E.J.1    Rodriguez-Torres, M.2    Nelson, D.E.3
  • 38
    • 79960471533 scopus 로고    scopus 로고
    • Once daily PSI-7977 plus PEGIFN/RBV in a phase 2B trial: Rapid virologic suppression in treatment-naive patients with HCV GT2/GT3
    • Lalezari J, Lawitz E, Rodriguez-Torres M, et al. Once daily PSI-7977 plus PEGIFN/RBV in a phase 2B trial: rapid virologic suppression in treatment-naive patients with HCV GT2/GT3. J Hepatol 2011; 54: S28.
    • (2011) J Hepatol , vol.54
    • Lalezari, J.1    Lawitz, E.2    Rodriguez-Torres, M.3
  • 39
    • 84863690573 scopus 로고    scopus 로고
    • ELECTRON: Once daily PSI-7977plus RBV in HCV GT1/2/3
    • Gane EJ, Stedman CA, Hyland RH, et al. ELECTRON: once daily PSI-7977plus RBV in HCV GT1/2/3. J Hepatol 2012; 56: S438-S439.
    • (2012) J Hepatol , vol.56
    • Gane, E.J.1    Stedman, C.A.2    Hyland, R.H.3
  • 40
    • 84855248040 scopus 로고    scopus 로고
    • Once daily PSI-7977 plus RBV: Pegylated interferon alfa not required for complete rapid viral response in treatment naive patients with HCV GT2 or GT3
    • Gane EJ, Stedman C, Hyland RH, et al. Once daily PSI-7977 plus RBV: pegylated interferon alfa not required for complete rapid viral response in treatment naive patients with HCV GT2 or GT3. Hepatology 2011; 54: 377A.
    • (2011) Hepatology , vol.54
    • Gane, E.J.1    Stedman, C.2    Hyland, R.H.3
  • 41
    • 66149129922 scopus 로고    scopus 로고
    • The cyclophilin inhibitor Debio 025 combined with PEG IFNalpha2a significantly reduces viral load in treatment-naive hepatitis C patients
    • Flisiak R, Feinman SV, Jablkowski M, et al. The cyclophilin inhibitor Debio 025 combined with PEG IFNalpha2a significantly reduces viral load in treatment-naive hepatitis C patients. Hepatology 2009; 49: 1460-1468.
    • (2009) Hepatology , vol.49 , pp. 1460-1468
    • Flisiak, R.1    Feinman, S.V.2    Jablkowski, M.3
  • 42
    • 79955815806 scopus 로고    scopus 로고
    • Sustained virological response with 29 days of Debio 025 monotherapy in hepatitis C virus genotype 3
    • Patel H, Heathcote EJ,. Sustained virological response with 29 days of Debio 025 monotherapy in hepatitis C virus genotype 3. Gut 2011; 60: 879.
    • (2011) Gut , vol.60 , pp. 879
    • Patel, H.1    Heathcote, E.J.2
  • 43
    • 84863704212 scopus 로고    scopus 로고
    • Alisporivir plus ribavirin is highly effective as interferon-free or interferon-add-on regimen in previously untreated HCV-GT2or GT3 patients: SVR12 results from VITAL-1 phase 2b study
    • Pawlostky JM, Sarin SK, Foster G, et al. Alisporivir plus ribavirin is highly effective as interferon-free or interferon-add-on regimen in previously untreated HCV-GT2or GT3 patients: SVR12 results from VITAL-1 phase 2b study. J Hepatol 2012; 56: S553.
    • (2012) J Hepatol , vol.56
    • Pawlostky, J.M.1    Sarin, S.K.2    Foster, G.3
  • 44
    • 84863678711 scopus 로고    scopus 로고
    • Potent viral suppression with the all-oral combination of daclatasvir (NS5A inhibitor) and GS-7977 (nucleotide NS5B inhibitor +/- ribavirin in treatment-naive patients with chronic HCV GT1,2, or 3
    • Sulkowski M, Gardiner D, Lawitz E, et al. Potent viral suppression with the all-oral combination of daclatasvir (NS5A inhibitor) and GS-7977 (nucleotide NS5B inhibitor +/- ribavirin in treatment-naive patients with chronic HCV GT1,2, or 3. J Hepatol 2012; 56: S560.
    • (2012) J Hepatol , vol.56
    • Sulkowski, M.1    Gardiner, D.2    Lawitz, E.3
  • 45
    • 84863710462 scopus 로고    scopus 로고
    • Peginterferon lambda-1A compared to peginterferon alfa-2A in treatment-naive patients with HCV genotypes 2 or 3: First SVR 24 results from EMERGE phase IIB
    • Zeuzem S, Arora S, Bacon B, et al. Peginterferon lambda-1A compared to peginterferon alfa-2A in treatment-naive patients with HCV genotypes 2 or 3: first SVR 24 results from EMERGE phase IIB. J Hepatol 2012; 56: S5.
    • (2012) J Hepatol , vol.56
    • Zeuzem, S.1    Arora, S.2    Bacon, B.3
  • 46
    • 84863696020 scopus 로고    scopus 로고
    • Rapid and sustained achievement of undetectable HCV RNA during treatment with ritonavir-boosted danoprevir/PEGIFN alfa-2A/RBV in HCV genotype 1 or 4 patients: DAUPHINE week 12 interim analysis
    • Everson G, Cooper C, Hezode C, et al. Rapid and sustained achievement of undetectable HCV RNA during treatment with ritonavir-boosted danoprevir/PEGIFN alfa-2A/RBV in HCV genotype 1 or 4 patients: DAUPHINE week 12 interim analysis. J Hepatol 2012; 56: S466.
    • (2012) J Hepatol , vol.56
    • Everson, G.1    Cooper, C.2    Hezode, C.3
  • 47
    • 84863680448 scopus 로고    scopus 로고
    • Efficacy and safety of mericitabine in combination with PEG-IFN alfa-2A/RBV in G1/4 treatment naive HCV patients: Final analysis from the PROPEL study
    • Wedemeyer H, Jensen D, Herring Jr R, et al. Efficacy and safety of mericitabine in combination with PEG-IFN alfa-2A/RBV in G1/4 treatment naive HCV patients: final analysis from the PROPEL study. J Hepatol 2012; 56: S481.
    • (2012) J Hepatol , vol.56
    • Wedemeyer, H.1    Jensen, D.2    Herring, Jr.R.3
  • 48
    • 84863650706 scopus 로고    scopus 로고
    • SVR-12 among G1/4 treatment-naive patients receiving mericitabine in combination with PEG-IFN alfa-2A/RBV: Interim analysis from the JUMP-C study
    • Pockros P, Jensen D, Tsai N, et al. SVR-12 among G1/4 treatment-naive patients receiving mericitabine in combination with PEG-IFN alfa-2A/RBV: interim analysis from the JUMP-C study. J Hepatol 2012; 56: S477-S478.
    • (2012) J Hepatol , vol.56
    • Pockros, P.1    Jensen, D.2    Tsai, N.3
  • 49
    • 84863687914 scopus 로고    scopus 로고
    • PSI-7977 with PEG/RBV elicits rapid declines in HCV RNA in patients with HCV GT-4 and GT-6
    • Hassanein T, Nelson DR, Lawitz E, et al. PSI-7977 with PEG/RBV elicits rapid declines in HCV RNA in patients with HCV GT-4 and GT-6. GAJ 2011; 7: 57.
    • (2011) GAJ , vol.7 , pp. 57
    • Hassanein, T.1    Nelson, D.R.2    Lawitz, E.3
  • 50
    • 84863703699 scopus 로고    scopus 로고
    • ATOMIC: 97% RVR for PSI-7977+PEG/RBV × 12 week regimen in HCV GT1: An end to response-guided therapy?
    • Kowdley KV, Lawitz E, Crespo I, et al. ATOMIC: 97% RVR for PSI-7977+PEG/RBV × 12 week regimen in HCV GT1: an end to response-guided therapy? J Hepatol 2012; 56: S1.
    • (2012) J Hepatol , vol.56
    • Kowdley, K.V.1    Lawitz, E.2    Crespo, I.3
  • 51
    • 84857822530 scopus 로고    scopus 로고
    • BMS-790052, A NS5A replication complec inhibitor combined with peginterferon alfa 2a and ribavirin in treatment naive HCV-genotype 1 or 4 patients: Phase 2B AI444010 study interim week 12 results
    • Hezode C, Hirschfield GM, Ghesquiere W, et al. BMS-790052, A NS5A replication complec inhibitor combined with peginterferon alfa 2a and ribavirin in treatment naive HCV-genotype 1 or 4 patients: phase 2B AI444010 study interim week 12 results. Hepatology 2011; 54: 474A.
    • (2011) Hepatology , vol.54
    • Hezode, C.1    Hirschfield, G.M.2    Ghesquiere, W.3
  • 52
    • 80051943544 scopus 로고    scopus 로고
    • Hepatitis C therapy: Other players in the game
    • Ahn J, Flamm SL,. Hepatitis C therapy: other players in the game. Clin Liver Dis 2011; 15: 641-656.
    • (2011) Clin Liver Dis , vol.15 , pp. 641-656
    • Ahn, J.1    Flamm, S.L.2
  • 53
    • 67650558979 scopus 로고    scopus 로고
    • Nitazoxanide for the treatment of chronic hepatitis C new opportunities but new challenges?
    • Mederacke I, Wedemeyer H,. Nitazoxanide for the treatment of chronic hepatitis C new opportunities but new challenges? Ann Hepatol 2009; 8: 166-168.
    • (2009) Ann Hepatol , vol.8 , pp. 166-168
    • Mederacke, I.1    Wedemeyer, H.2


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