Structure-function relationships of the Mycobacterium tuberculosis transcription factor WhiB1

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Smith, Laura J ^a   Stapleton, Melanie R ^a   Buxton, Roger S ^b   Green, Jeffrey ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; ASPARTIC ACID; CYSTEINE; DNA; IRON; LYSINE; NITRIC OXIDE; SULFUR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR WHIB1; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; BETA SHEET; CARBOXY TERMINAL SEQUENCE; DNA BINDING; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PREDICTION; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN MOTIF; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BACTERIAL PROTEINS; BINDING SITES; CYSTEINE; IRON-SULFUR PROTEINS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MYCOBACTERIUM TUBERCULOSIS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; TRANSCRIPTION FACTORS;

ACTINOBACTERIA (CLASS); MYCOBACTERIUM TUBERCULOSIS;

EID: 84863629218     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0040407     Document Type: Article

References (15)

1. WHO, World Health Organization 2011 (2011) Global Tuberculosis Control. WHO Press WHO/HTM/TB/2011.16.
2. Voskuil MI, Schnappinger D, Visconti KC, Harrell MI, Dolganov GM, et al. (2003) Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program. J Exptl Med 198: 705-713.
3. Voskuil MI, Bartek IL, Visconti K, Schoolnik GK (2011) The response of Mycobacterium tuberculosis to reactive oxygen and nitrogen species. Frontiers in Microbiol 2: article 105.
4. Erht S, Schnappinger D, (2009) Mycobacterial survival strategies in the phagosome: defence against host stresses. Cell Microbiol 11: 1170-1178.
5. Smith LJ, Stapleton MR, Fullstone GJM, Crack JC, Thomson AJ, et al. (2010) Mycobacterium tuberculosis WhiB1 is an essential DNA-binding protein with a nitric oxide-sensitive iron-sulfur cluster. Biochem J 432: 417-427.
6. Crack JC, Smith LJ, Stapleton MR, Peck J, Watmough NJ, et al. (2011) Mechanistic insights into the nitrosylation of the [4Fe-4S] cluster of WhiB-like proteins. J Am Chem Soc 133: 1112-1121.
7. Stapleton MR, Smith LJ, Hunt DM, Buxton RS, Green J, (2012) Mycobacterium tuberculosis WhiB1 represses transcription of the essential chaperonin GroEL2. Tuberculosis (Edinb) doi:10.1016/j.tube2012.03.001.
8. Ralph AP, Kelly PM, Anstey MN, (2008) L-Arginine and vitamin D: novel adjunctive immunotherapies in tuberculosis. Trends Microbiol 16: 336-344.
9. Flynn JL, Scanga CA, Tanaka KE, Chan J, (1998) Effects of aminoguanidine on latent murine tuberculosis. J Immunol 160: 1796-1803.
10. den Hengst CD, Buttner MJ, (2008) Redox control in actinobacteria. Biochim Biophys Acta 1780: 1201-1216.
11. Rybniker J, Nowag A, van Grumpel E, Nissen N, Robinson N, et al. (2010) Insights into the function of the WhiB-like protein of mycobacteriophage TM4 - a transcriptional inhibitor of WhiB2. Mol Microbiol 77: 642-657.
12. Ragahund TR, Bishai WR, (2006) Mapping essential domains of Mycobacterium smegmatis WhmD: insights into WhiB structure and function. J Bacteriol 188: 6966-6976.
13. Thompson JD, Higgins DG, Gibson TJ, (1994) CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucl Acids Res 22: 4673-4680.
14. Singh A, Guidry L, Narasimhulu KV, Mai D, Trombley J, et al. (2007) Mycobacterium tuberculosis WhiB3 responds to O2 and nitric oxide via its [4Fe-4S] cluster and is essential for nutrient starvation survival. Proc Natl Acad Sci USA 104: 11562-11567.
15. Jakimowicz P, Cheesman MR, Bishai WR, Chater KF, Thomson AJ, et al. (2005) Evidence that the Streptomyces developmental protein WhiD, a member of the WhiB family, binds a [4Fe-4S] cluster. J Biol Chem 280: 8309-8315.