Structural effect of the L16Q, K50E, and R53P mutations on homeodomain of pituitary homeobox protein 2

International Journal of Biological Macromolecules

Volumn 51, Issue 3, 2012, Pages 305-313

  Rajasekaran, M ^a,b,c   Chen, Chinpan ^a  

^a INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^b NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^c INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

Author keywords

DNA binding; Gromacs; Molecular dynamics simulation; Mutation; PITX2 homeodomain; Rieger syndrome

Indexed keywords

ARGININE; GLUTAMIC ACID; GLUTAMINE; LEUCINE; LYSINE; PROLINE; TRANSCRIPTION FACTOR PITX2;

ALPHA HELIX; ARTICLE; CONTROLLED STUDY; DNA BINDING; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR DYNAMICS; MUTATIONAL ANALYSIS; PROTEIN DOMAIN; PROTEIN STABILITY; RIEGER SYNDROME; SIMULATION; SINGLE NUCLEOTIDE POLYMORPHISM; STATIC ELECTRICITY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SURFACE PROPERTY; TEMPERATURE DEPENDENCE; WILD TYPE;

EID: 84863625294     PISSN: 01418130     EISSN: 18790003     Source Type: Journal    
DOI: 10.1016/j.ijbiomac.2012.05.008     Document Type: Article

References (50)

1. Semina E.V., Reiter R., Leysens N.J., Alward W.L., Small K.W., Datson N.A., Siegel-Bartelt J., Bierke-Nelson D., Bitoun P., Zabel B.U., Carey J.C., Murray J.C. Nature Genetics 1996, 14:392-399.
2. Gehring W.J., Qian Y.Q., Billeter M., Furukubo-Tokunaga K., Schier A.F., Resendez-Perez D., Affolter M., Otting G., Wuthrich K. Cell 1994, 78:211-223.
3. Kumar J., Moses K. Genes and Development 1997, 11:2023-2028.
4. McGinnis W., Krumlauf R. Cell 1992, 68:283-302.
5. Gage P.J., Camper S.A. Human Molecular Genetics 1997, 6:457-464.
6. Mucchielli M.L., Mitsiadis T.A., Raffo S., Brunet J.F., Proust J.P., Goridis C. Developmental Biology 1997, 189:275-284.
7. Hjalt T.A., Semina E.V., Amendt B.A., Murray J.C. Developmental Dynamics 2000, 218:195-200.
8. Rieger H. Z. Augenheilk 1935, 86:333.
9. Perveen R., Lloyd I.C., Clayton-Smith J., Churchill A., van Heyningen V., Hanson I., Taylor D., McKeown C., Super M., Kerr B., Winter R., Black G.C. Investigative Ophthalmology and Visual Science 2000, 41:2456-2460.
10. Xia K., Wu L., Liu X., Xi X., Liang D., Zheng D., Cai F., Pan Q., Long Z., Dai H., Hu Z., Tang B., Zhang Z., Xia J. Journal of Medical Genetics 2004, 41:e129.
11. Chaney B.A., Clark-Baldwin K., Dave V., Ma J., Rance M. Biochemistry 2005, 44:7497-7511.
12. Qian Y.Q., Billeter M., Otting G., Muller M., Gehring W.J., Wuthrich K. Cell 1989, 59:573-580.
13. Kornberg T.B. Journal of Biological Chemistry 1993, 268:26813-26816.
14. Kissinger C.R., Liu B.S., Martin-Blanco E., Kornberg T.B., Pabo C.O. Cell 1990, 63:579-590.
15. Banerjee-Basu S., Baxevanis A.D. Human Mutation 1999, 14:312-319.
16. Amendt B.A., Sutherland L.B., Semina E.V., Russo A.F. Journal of Biological Chemistry 1998, 273:20066-20072.
17. Saadi I., Semina E.V., Amendt B.A., Harris D.J., Murphy K.P., Murray J.C., Russo A.F. Journal of Biological Chemistry 2001, 276:23034-23041.
18. Amendt B.A., Semina E.V., Alward W.L. Cellular and Molecular Life Sciences 2000, 57:1652-1666.
19. Kozlowski K., Walter M.A. Human Molecular Genetics 2000, 9:2131-2139.
20. Van Der Spoel D., Lindahl E., Hess B., Groenhof G., Mark A.E., Berendsen H.J. Journal of Computational Chemistry 2005, 26:1701-1718.
21. Achary M.S., Reddy A.B., Chakrabarti S., Panicker S.G., Mandal A.K., Ahmed N., Balasubramanian D., Hasnain S.E., Nagarajaram H.A. Biophysical Journal 2006, 91:4329-4339.
22. Berendsen J.P.M.P.H.J.C., van Gunsteren W.F., DiNola A., Haak J.R. Journal of Chemical Physics 1984, 81:3684-3690.
23. Parrinello M., Rahman A. Journal of Applied Physics 1981, 52:7182-7190.
24. Darden T., York D., Pedersen L. Journal of Chemical Physics 1993, 98:10089-10092.
25. Hess B., Bekker H., Berendsen H.J.C., Fraaije J.G.E.M. Journal of Computational Chemistry 1997, 18:1463-1472.
26. Miyamoto S., Kollman P.A. Journal of Computational Chemistry 1992, 13:952-962.
27. Hubbard S.J., Thornton J.M. Department of Biochemistry and Molecular Biology 1993, University College of London.
28. McDonald I.K., Thornton J.M. Journal of Molecular Biology 1994, 238:777-793.
29. DeLano W.L. The PyMOL Molecular Graphics System 2002, DeLano Scientific, San Carlos, CA, USA.
30. Rajasekaran M., Abirami S., Chen C. PLoS One 2011, 6:e25801.
31. Anderson P.C., Daggett V. Journal of the American Chemical Society 2009, 131:9506-9515.
32. Cordomi A., Ramon E., Garriga P., Perez J.J. Journal of Biomolecular Structure and Dynamics 2008, 25:573-587.
33. Blaise M.C., Bhattacharyya D., Sowdhamini R., Pradhan N. Journal of Biomolecular Structure and Dynamics 2005, 22:399-410.
34. Hao G.F., Yang G.F. PLoS One 2010, 5:e10742.
35. Biocca S., Falconi M., Filesi I., Baldini F., Vecchione L., Mango R., Romeo F., Federici G., Desideri A., Novelli G. PLoS One 2009, 4:e4648.
36. Roy S., Thakur A.R. Journal of Biomolecular Structure and Dynamics 2010, 27:443-456.
37. Zhao X., Huang X.R., Sun C.C. Journal of Structural Biology 2006, 155:426-437.
38. Gutmanas A., Billeter M. Proteins 2004, 57:772-782.
39. B.A. Chaney, PhD diss., University of Cincinnati, (2005).
40. Yang S.Y., Yang X.L., Yao L.F., Wang H.B., Sun C.K. Journal of Molecular Graphics and Modelling 2011, 29:920-927.
41. Duboule D. Guidebook to the Homeobox Genes 1994, Oxford University Press, New York.
42. Ades S.E., Sauer R.T. Biochemistry 1994, 33:9187-9194.
43. Connolly J.P., Augustine J.G., Francklyn C. Nucleic Acids Research 1999, 27:1182-1189.
44. Pomerantz J.L., Sharp P.A. Biochemistry 1994, 33:10851-10858.
45. Chi Y.I. Human Genetics 2005, 116:433-444.
46. Boncinelli E. Current Opinion in Genetics and Development 1997, 7:331-337.
47. Muragaki Y., Mundlos S., Upton J., Olsen B.R. Science 1996, 272:548-551.
48. Nakamura T., Largaespada D.A., Lee M.P., Johnson L.A., Ohyashiki K., Toyama K., Chen S.J., Willman C.L., Chen I.M., Feinberg A.P., Jenkins N.A., Copeland N.G., Shaughnessy J.D. Nature Genetics 1996, 12:154-158.
49. D'Elia A.V., Tell G., Paron I., Pellizzari L., Lonigro R., Damante G. Human Mutation 2001, 18:361-374.
50. Borrow J., Shearman A.M., Stanton V.P., Becher R., Collins T., Williams A.J., Dube I., Katz F., Kwong Y.L., Morris C., Ohyashiki K., Toyama K., Rowley J., Housman D.E. Nature Genetics 1996, 12:159-167.